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Basic and diluted earnings per share (Details) - shares	3 Months Ended		9 Months Ended
	Sep. 30, 2021	Sep. 30, 2020	Sep. 30, 2021	Sep. 30, 2020
Basic and diluted earnings per share
Total potential dilutive ordinary shares	4,200,111	11,705,960	3,309,299	11,705,960
BMS Warrants | Bristol Myers Squibb
Basic and diluted earnings per share
Total potential dilutive ordinary shares		8,071,000		8,071,000
Stock options | Previous plan
Basic and diluted earnings per share
Total potential dilutive ordinary shares	3,357,412	2,960,158	2,572,470	2,960,158
Stock options | ESPP
Basic and diluted earnings per share
Total potential dilutive ordinary shares	1,219	1,997	1,219	1,997
Non-vested RSUs and PSUs
Basic and diluted earnings per share
Total potential dilutive ordinary shares	841,480	672,805	735,610	672,805

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- Definition

Securities (including those issuable pursuant to contingent stock agreements) that could potentially dilute basic earnings per share (EPS) or earnings per unit (EPU) in the future that were not included in the computation of diluted EPS or EPU because to do so would increase EPS or EPU amounts or decrease loss per share or unit amounts for the period presented.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 260
-SubTopic 10
-Section 50
-Paragraph 1
-Subparagraph (c)
-URI http://asc.fasb.org/extlink&oid=6371337&loc=d3e3550-109257

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+ References

No definition available.

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