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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands
 9 Months Ended
Sep. 30, 2021
Sep. 30, 2020
Cash flows from operating activities    
Net income / (loss) $ 321,381 $ (124,325)
Adjustments to reconcile net income / (loss) to net cash generated from / (used in) operating activities:    
Depreciation and amortization expense 5,447 8,354
Share-based compensation expense 18,747 16,450
Deferred tax expense 3,560  
Changes in fair value of contingent consideration and derivative financial instruments 416 (2,531)
Unrealized foreign exchange (gains) / loss, net (23,242) 7,758
Other non-cash items, net (2,862) (2,082)
Changes in operating assets and liabilities:    
Accounts receivable, prepaid expenses, and other current assets and receivables (1,993) (1,183)
Accounts payable 2,003 (3,724)
Accrued expenses, other liabilities, and operating leases 11,592 3,630
Net cash generated from / (used in) operating activities 335,049 (97,653)
Cash flows from investing activities    
Acquisition of Corlieve, net of cash acquired (49,949)  
Purchases of intangible assets   (2,314)
Purchases of property, plant, and equipment (13,885) (4,475)
Net cash used in investing activities (63,834) (6,789)
Cash flows from financing activities    
Proceeds from loan increment, net of debt issuance costs 34,603  
Proceeds from issuance of ordinary shares 30,899  
Share issuance costs from issuance of ordinary shares (1,334)  
Proceeds from issuance of ordinary shares related to employee stock option and purchase plans 1,971 3,688
Repayment of debt acquired through acquisition of Corlieve (1,175)  
Net cash generated from financing activities 64,964 3,688
Currency effect on cash, cash equivalents and restricted cash (2,589) 2,235
Net increase / (decrease) in cash, cash equivalents and restricted cash 333,590 (98,519)
Cash, cash equivalents and restricted cash at beginning of period 247,680 380,726
Cash, cash equivalents and restricted cash at the end of period 581,270 282,207
Cash and cash equivalents 578,464 279,493
Restricted cash related to leasehold and other deposits 2,806 2,714
Total cash, cash equivalents and restricted cash 581,270 282,207
Supplemental cash flow disclosures:    
Cash paid for interest (4,503) (3,342)
Non-cash increase in accounts payables and accrued expenses and other current liabilities related to purchases of intangible assets and property, plant, and equipment $ 415 $ 116