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Share-based compensation - Summary of share-based compensation expense and unrecognized costs (Details) - USD ($) $ in Thousands		1 Months Ended		3 Months Ended		6 Months Ended
	May 31, 2021	Jun. 30, 2021	Jun. 30, 2018	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021
2014 Plan
Share-based compensation
Increase in authorized shares	8,601,471	12,601,471
Share-based compensation expense				$ 7,813	$ 7,030	$ 14,682	$ 12,792
Unrecognized compensation costs				65,859		$ 65,859
Weighted-average remaining period for recognition (in years)						2 years 5 months 19 days
ESPP
Share-based compensation
Share-based compensation expense				6	9	$ 12	17
2014 Plans and ESPP
Share-based compensation
Share-based compensation expense				7,813	7,030	14,682	12,792
Research and development expenses | 2014 Plans and ESPP
Share-based compensation
Share-based compensation expense				4,306	3,294	8,360	5,974
Selling, general and administrative expense | 2014 Plans and ESPP
Share-based compensation
Share-based compensation expense				3,359	3,737	6,174	6,818
Cost of manufacturing services revenues | 2014 Plans and ESPP
Share-based compensation
Share-based compensation expense				148		148
Share options | 2014 Plan
Share-based compensation
Unrecognized compensation costs				32,429		$ 32,429
Weighted-average remaining period for recognition (in years)						2 years 9 months 3 days
Share options | 2014 Plans and ESPP
Share-based compensation
Share-based compensation expense				3,438	3,350	$ 6,693	6,190
Restricted share units ("RSUs") | 2014 Plan
Share-based compensation
Unrecognized compensation costs				33,228		$ 33,228
Weighted-average remaining period for recognition (in years)						2 years 2 months 12 days
Restricted share units ("RSUs") | 2014 Plans and ESPP
Share-based compensation
Share-based compensation expense				4,127	3,222	$ 7,397	5,782
Performance Share Awards | 2014 Plan
Share-based compensation
Unrecognized compensation costs				202		$ 202
Weighted-average remaining period for recognition (in years)						2 months 15 days
Performance Share Awards | 2014 Plans and ESPP
Share-based compensation
Share-based compensation expense				$ 242	$ 449	$ 580	$ 803
Employee Stock [Member] | ESPP
Share-based compensation
Ordinary shares available for issue		130,852	150,000	121,414	130,852	121,414	130,852
Discounted rate for purchase of shares			85.00%

X

- Definition

Amount of expense for award under share-based payment arrangement. Excludes amount capitalized.

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-Publisher FASB
-Name Accounting Standards Codification
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Amount of cost not yet recognized for nonvested award under share-based payment arrangement.

+ References

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Weighted-average period over which cost not yet recognized is expected to be recognized for award under share-based payment arrangement, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents reported fact of one year, five months, and thirteen days.

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- Definition

Discount rate from fair value on purchase date that participants pay for shares.

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Number of additional shares authorized for issuance under share-based payment arrangement.

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