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CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2020
Total revenues | $ 106,483 | $ 524,002 | $ 37,514
Operating expenses: |  |  |
Cost of license revenues | (1,254) | (24,976) |
Cost of contract manufacturing revenues | (2,089) |  |
Research and development expenses | (197,591) | (143,548) | (122,400)
Selling, general and administrative expenses | (55,059) | (56,290) | (42,580)
Total operating expenses | (255,993) | (224,814) | (164,980)
Other income | 7,171 | 12,306 | 3,342
Other expense | (820) | (876) | (1,302)
(Loss) / income from operations | (143,159) | 310,618 | (125,426)
Interest income | 609 | 162 | 938
Interest expense | (11,704) | (7,474) | (3,825)
Foreign currency gains / (losses), net | 23,235 | 29,660 | (13,613)
Other non-operating gains / (losses), net | 2,760 | (160) | 483
(Loss) / income before income tax benefit / (expense) | (128,259) | 332,806 | (141,443)
Income tax benefit / (expense) | 1,470 | (3,217) | 16,419
Net (loss) / income | (126,789) | 329,589 | (125,024)
Other comprehensive loss: |  |  |
Foreign currency translation adjustments | (29,435) | (38,763) | 16,596
Total comprehensive (loss) / gain | $ (156,224) | $ 290,826 | $ (108,428)
Earnings per ordinary share - basic |  |  |
Basic net (loss) / income per ordinary share | $ (2.71) | $ 7.17 | $ (2.81)
Earnings per ordinary share - diluted |  |  |
Diluted net (loss) / income per ordinary share | $ (2.71) | $ 7.04 | $ (2.81)
Weighted average shares - basic | 46,735,045 | 45,986,467 | 44,466,365
Weighted average shares - diluted | 46,735,045 | 46,840,972 | 44,466,365
License revenues |  |  |
Total revenues | $ 100,000 | $ 517,400 | $ 4,352
License revenues from related parties |  |  |
Total revenues | 0 | 0 | 32,967
Contract manufacturing revenues |  |  |
Total revenues | 1,717 |  |
Collaboration revenues |  |  |
Total revenues | $ 4,766 | $ 6,602 | 59
Collaboration revenues from related parties |  |  |
Total revenues |  |  | $ 136

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