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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2020
Cash flows from operating activities |  |  |
Net (loss) / income | $ (126,789) | $ 329,589 | $ (125,024)
Adjustments to reconcile net (loss) / income to net cash (used in) / generated from operating activities: |  |  |
Depreciation and amortization expense | 8,537 | 7,299 | 10,648
Share-based compensation expense | 34,204 | 25,635 | 21,831
Deferred tax (income) / expense | (1,470) | 3,210 | (16,419)
Changes in fair value of contingent consideration and derivative financial instrument, net | 4,320 | 6,843 | (483)
Unrealized foreign exchange (gains) / losses, net | (22,083) | (31,335) | 14,730
Change in deferred revenue |  |  | (33,642)
Other non-cash items, net | 1,605 | (2,800) |
Changes in operating assets and liabilities: |  |  |
Accounts receivable, prepaid expenses, and other current assets and receivables | (4,083) | (3,959) | (6,967)
Contract asset related to CSL Behring milestone payments | (45,000) | (55,000) |
Inventories | (6,924) |  |
Accounts payable | 9,238 | (727) | (2,701)
Accrued expenses, other liabilities, and operating leases | 3,385 | 9,204 | 3,199
Net cash (used in) / generated from operating activities | (145,060) | 287,959 | (134,828)
Cash flows from investing activities |  |  |
Investment in investment securities | (163,146) | 0 |
Purchases of property, plant, and equipment | (17,688) | (17,438) | (7,271)
Acquisition of Corlieve, net of cash acquired | (1,900) | (49,949) |
Purchases of intangible assets |  |  | (2,213)
Net cash used in investing activities | (182,734) | (67,387) | (9,484)
Cash flows from financing activities |  |  |
Proceeds from issuance of ordinary shares related to employee stock option and purchase plans | 1,445 | 2,798 | 7,444
Proceeds from loan increment, net of debt issuance costs |  | 64,067 |
Proceeds from issuance of ordinary shares |  | 30,899 |
Share issuance costs from issuance of ordinary shares |  | (1,334) |
Repayment of debt acquired through acquisition of Corlieve |  | (1,572) |
Net cash generated from financing activities | 1,445 | 94,858 | 7,444
Currency effect on cash, cash equivalents and restricted cash | (1,831) | (3,757) | 3,822
Net (decrease) / increase in cash, cash equivalents and restricted cash | (328,180) | 311,673 | (133,046)
Cash, cash equivalents and restricted cash at beginning of period | 559,353 | 247,680 | 380,726
Cash, cash equivalents and restricted cash at the end of period | 231,173 | 559,353 | 247,680
Cash and cash equivalents | 228,012 | 556,256 | 244,932
Restricted cash related to leasehold and other deposits | 3,161 | 3,097 | 2,748
Total cash, cash equivalents and restricted cash | 231,173 | 559,353 | 247,680
Supplemental cash flow disclosures: |  |  |
Cash paid for interest | (9,247) | (6,539) | (4,131)
Non-cash (decrease) / increase in accounts payables and accrued expenses and other current liabilities related to purchases of property, plant, and equipment | $ (964) | $ 1,488 | $ 630

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