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Share-based compensation (Tables) | 12 Months Ended
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Dec. 31, 2022
Share-based compensation |
Schedule of share-based compensation expense by classification included in consolidated statements of operations and comprehensive loss | ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
| ​ | Year ended December 31,
​ | ​ | 2022 | ​ | 2021 | ​ | 2020
​ | ​ | (in thousands)
Cost of manufacturing services revenue | ​ | $ | 323 | ​ | $ | — | ​ | $ | —
Research and development | ​ | ​ | 18,402 | ​ | ​ | 12,834 | ​ | ​ | 11,995
Selling, general and administrative | ​ | ​ | 15,479 | ​ | ​ | 12,801 | ​ | ​ | 9,836
Total | ​ | $ | 34,204 | ​ | $ | 25,635 | ​ | $ | 21,831
​
Schedule of share-based compensation expense | ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | Year ended December 31,
​ | ​ | 2022 | ​ | 2021 | ​ | 2020
​ | ​ | (in thousands)
Award type/ESPP | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
Share options | ​ | $ | 13,425 | ​ | $ | 12,477 | ​ | $ | 11,434
Restricted share units | ​ | ​ | 15,486 | ​ | ​ | 11,347 | ​ | ​ | 7,364
Performance share units | ​ | ​ | 5,267 | ​ | ​ | 1,783 | ​ | ​ | 2,990
Employee share purchase plan | ​ | ​ | 26 | ​ | ​ | 28 | ​ | ​ | 43
Total | ​ | $ | 34,204 | ​ | $ | 25,635 | ​ | $ | 21,831
​
Schedule of unrecognized compensation cost related to unvested awards | ​
​ | ​ | ​ | ​ | ​ | ​
​ |  | Unrecognized |  | Weighted average
​ |  | share-based |  | remaining
​ | ​ | compensation | ​ | period for
​ | ​ | expense | ​ | recognition
​ | ​ | (in thousands) | ​ | (in years)
Award type | ​ | ​ | ​ | ​ | ​
Share options | ​ | $ | 24,420 | ​ | 2.48
Restricted share units | ​ | ​ | 24,924 | ​ | 1.90
Performance share units | ​ | ​ | 184 | ​ | 0.14
Total | ​ | $ | 49,528 | ​ | 2.18
​
Schedule of weighted-average assumptions for fair value of option issued | ​
​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | Year ended December 31,
Assumptions |  | 2022 |  | 2021 | ​ | 2020
Expected volatility | ​ | 70% | ​ | 75% | ​ | 70%
Expected terms | ​ | 10 years | ​ | 10 years | ​ | 10 years
Risk free interest rate | ​ | 2.12% - 4.16% | ​ | 1.21 - 1.86% | ​ | 0.76% - 1.44%
Expected dividend yield | ​ | 0% | ​ | 0% | ​ | 0%
​
Summary of RSUs activity | ​
​ | ​ | ​ | ​ | ​ | ​
​ | ​ | RSU
​ |  | ​ |  | Weighted average
​ | ​ | Number of | ​ | grant-date fair
​ | ​ | ordinary shares | ​ | value
Non-vested at December 31, 2021 | ​ | 710,617 | ​ | $ | 38.89
Granted | ​ | 1,604,533 | ​ | $ | 16.10
Vested | ​ | (292,688) | ​ | $ | 39.31
Forfeited | ​ | (203,688) | ​ | $ | 23.39
Non-vested at December 31, 2022 | ​ | 1,818,774 | ​ | $ | 20.46
​ | ​ | ​ | ​ | ​ | ​
Total weighted average grant date fair value of RSUs granted during the period (in $ millions) | ​ | ​ | ​ | $ | 25.8
Granted to directors and officers during the period (shares, $ in millions) | ​ | 380,288 | ​ | $ | 6.0
​
Summary of PSUs activity | ​
​ | ​ | ​ | ​ | ​ | ​
​ | ​ | PSU
​ |  | ​ |  | Weighted average
​ | ​ | Number of | ​ | grant-date fair
​ | ​ | ordinary shares | ​ | value
Non-vested at December 31, 2021 | ​ | 632,930 | ​ | $ | 33.54
Granted | ​ | 34,700 | ​ | $ | 15.11
Vested | ​ | (213,145) | ​ | $ | 40.46
Forfeited | ​ | (53,795) | ​ | $ | 29.35
Non-vested at December 31, 2022 | ​ | 400,690 | ​ | $ | 28.82
​ | ​ | ​ | ​ | ​ | ​
Total weighted average grant date fair value of PSUs granted during the period (in $ millions) | ​ | ​ | ​ | $ | 0.5
​
2014 Plan. |
Share-based compensation |
Summary of option activity | ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | Options
​ | ​ | Number of | ​ | Weighted average | ​ | Weighted average | ​ | Aggregate intrinsic
​ |  | ordinary shares |  | exercise price |  | remaining contractual life |  | value
​ | ​ | ​ | ​ | ​ | ​ | ​ | in years | ​ | ​ | (in thousands)
Outstanding at December 31, 2021 | ​ | 3,308,325 | ​ | $ | 31.02 | ​ | 7.05 | ​ | $ | 8,660
Granted | ​ | 1,426,966 | ​ | $ | 15.90 | ​ | ​ | ​ | ​ | ​
Forfeited | ​ | (204,224) | ​ | $ | 38.29 | ​ | ​ | ​ | ​ | ​
Expired | ​ | (154,794) | ​ | $ | 36.86 | ​ | ​ | ​ | ​ | ​
Exercised | ​ | (138,356) | ​ | $ | 7.81 | ​ | ​ | ​ | ​ | ​
Outstanding at December 31, 2022 | ​ | 4,237,917 | ​ | $ | 26.13 | ​ | 7.14 | ​ | ​ | 17,848
Thereof, fully vested and exercisable on December 31, 2022 | ​ | 2,139,360 | ​ | $ | 28.82 | ​ | 5.45 | ​ | ​ | 8,339
Thereof, outstanding and expected to vest after December 31, 2022 | ​ | 2,098,557 | ​ | $ | 23.38 | ​ | 8.86 | ​ | ​ | 9,509
Outstanding and expected to vest after December 31, 2021 | ​ | 1,521,500 | ​ | $ | 38.71 | ​ | ​ | ​ | ​ | ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
Total weighted average grant date fair value of options issued during the period (in $ millions) | ​ | ​ | ​ | $ | 12.9 | ​ | ​ | ​ | ​ | ​
Granted to directors and officers during the period (options, grant date fair value $ in millions) | ​ | 672,908 | ​ | $ | 5.9 | ​ | ​ | ​ | ​ | ​
Proceeds from option sales during the period (in $ millions) | ​ | ​ | ​ | $ | 1.3 | ​ | ​ | ​ | ​ | ​
​
Summary of information about weighted average grant-date fair value of options granted | ​
​ | ​ | ​ | ​ | ​ | ​
​ |  | ​ |  | Weighted average
​ | ​ | Options | ​ | grant‑date fair value
Granted, 2022 |  | 1,426,966 | ​ | $ | 9.04
Granted, 2021 |  | 1,174,893 | ​ | ​ | 20.95
Granted, 2020 |  | 653,852 | ​ | ​ | 28.08
Vested, 2022 | ​ | 652,635 | ​ | ​ | 22.27
Forfeited, 2022 | ​ | (204,224) | ​ | ​ | 22.17
​
Summary of summarizes information about the weighted average grant-date fair value of options outstanding and expected to vest | ​
​ | ​ | ​ | ​ | ​ | ​
​ |  | ​ |  | Weighted average
​ | ​ | Options | ​ | grant‑date fair value
Outstanding and expected to vest, 2022 |  | 2,098,557 | ​ | $ | 13.46
Outstanding and expected to vest, 2021 |  | 1,521,500 | ​ | ​ | 22.52
​
Summary of information about options exercised | ​
​ | ​ | ​ | ​ | ​ | ​
​ |  | Exercised |  | ​ | ​
​ | ​ | during the year | ​ | Intrinsic value
​ | ​ | ​ | ​ | (in thousands)
2022 |  | 138,356 | ​ | $ | 1,848
2021 |  | 241,496 | ​ |  | 5,046
2020 |  | 498,678 | ​ |  | 11,927
​
Restricted share units ("RSUs") |
Share-based compensation |
Summary of information about weighted average grant-date fair value of options granted | ​
​ | ​ | ​ | ​ | ​ | ​
​ |  | Granted |  | Weighted average
​ | ​ | during the year | ​ | grant‑date fair value
2022 |  | 1,604,533 | ​ | $ | 16.10
2021 |  | 574,921 | ​ | ​ | 36.14
2020 |  | 376,799 | ​ | ​ | 48.18
​
Summary of information about the total fair value of stock that vested | ​
​ | ​ | ​
​ | Total fair value
​ | (in thousands)
2022 | $ | 5,104
2021 |  | 8,063
2020 |  | 12,156
​
Performance Share Awards |
Share-based compensation |
Summary of information about weighted average grant-date fair value of options granted | ​
​ | ​ | ​ | ​ | ​ | ​
​ |  | Granted |  | Weighted average
​ | ​ | during the year | ​ | grant‑date fair value
2022 |  | 34,700 | ​ | $ | 15.11
2021 |  | 555,600 | ​ | $ | 30.19
2020 |  | 91,003 | ​ | $ | 57.56
​
Summary of information about the total fair value of stock that vested | ​
​ | ​ | ​
​ | Total fair value
​ | (in thousands)
2022 | $ | 4,450
2021 |  | 5,074
2020 |  | 21,852
​

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- Definition Tabular disclosure of the number and weighted-average grant date fair value for restricted stock units that were outstanding at the beginning and end of the year, and the number of restricted stock units that were granted, vested, or forfeited during the year. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(1) -URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901 + Details
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- Definition Tabular disclosure for stock option plans. Includes, but is not limited to, outstanding awards at beginning and end of year, grants, exercises, forfeitures, and weighted-average grant date fair value. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (d) -URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (e) -URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(1) -URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901 + Details
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