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Expenses by nature - Operating expenses excluding expenses presented in other expenses (Details) - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2020
Operating expenses: |  |  |
Employee-related expenses | $ 119,903 | $ 96,161 | $ 75,926
Laboratory and development expenses | 65,964 | 36,014 | 35,977
Office and housing expenses | 17,612 | 14,638 | 13,388
Legal and advisory expenses | 15,782 | 24,767 | 17,370
Other operating expenses | 8,510 | 10,528 | 8,772
Patent and license expenses | 9,548 | 3,748 | 2,899
Depreciation and amortization expenses | 8,250 | 7,299 | 10,648
Fair value loss - Corlieve contingent consideration | 7,081 | 6,683 |
Total | $ 252,650 | $ 199,838 | $ 164,980

X
- Definition Amount of expense charged against earnings to allocate the cost of tangible and intangible assets over their remaining economic lives and the write-down of assets. + References No definition available. + Details
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- Definition Amount of expense for fair value loss - Corlieve contingent consideration. + References No definition available. + Details
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- Definition Represents the expense for laboratory and development expense. + References No definition available. + Details
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X
- Definition Amount of expense provided in the period for legal costs incurred pertaining to resolved, pending or threatened litigation, including arbitration and mediation proceedings and fees charged for services from professionals such as doctors, lawyers and accountants. + References No definition available. + Details
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- Definition Amount of expense incurred for maintenance of office and housing expenses. + References No definition available. + Details
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X
- Definition The aggregate costs related to patent and license expenses. + References No definition available. + Details
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- Definition Amount of expense for salary, wage, profit sharing; incentive and equity-based compensation; and other employee benefit. + References Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef -Publisher FASB -Name Accounting Standards Codification -Topic 220 -SubTopic 10 -Section S99 -Paragraph 2 -Subparagraph (SX 210.5-03(b)(4)) -URI https://asc.fasb.org/extlink&oid=126953954&loc=SL114868664-224227 + Details
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X
- Definition Generally recurring costs associated with normal operations except for the portion of these expenses which can be clearly related to production and included in cost of sales or services. Excludes Selling, General and Administrative Expense. + References No definition available. + Details
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- Definition The total amount of other operating cost and expense items that are associated with the entity's normal revenue producing operation. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 220 -SubTopic 10 -Section S99 -Paragraph 2 -Subparagraph (SX 210.5-03.3) -URI https://asc.fasb.org/extlink&oid=126953954&loc=SL114868664-224227 + Details
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