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Income taxes - Changes in valuation allowance (Details) - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2020
Opening balance | $ 60,289 | $ 150,113 | $ 109,856
Changes recorded in the statement of operations | 20,593 | (88,858) | 30,568
Changes recorded in equity | (972) |  |
Increase related to 2021 and 2020 Dutch tax reforms |  | 1,897 | 18,287
Valuation allowance assumed in Corlieve acquisition |  | 545 |
Other changes including currency translation adjustments | (5,363) | (3,408) | 7,821
Ending balance | 74,547 | 60,289 | 150,113
Amount of valuation allowance for deferred tax assets within contributed capital as it relates to follow on offering costs. | $ 3,300 | $ 4,500 |
U.S. operations |  |  |
Changes recorded in the statement of operations |  |  | (16,419)
Release of valuation allowance related to expected current year and future periods recorded in profit and loss |  |  | $ (16,419)

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- Definition Amount of valuation allowance deferred tax asset changes recorded in equity. + References No definition available. + Details
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- Definition Amount of valuation allowance for deferred tax assets within contributed capital as it relates to follow on offering costs. + References No definition available. + Details
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- Definition Amount of deferred tax assets for which it is more likely than not that a tax benefit will not be realized. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c) -URI https://asc.fasb.org/extlink&oid=121826272&loc=d3e32537-109319 + Details
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