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Income taxes - Significant components of deferred taxes (Details) - USD ($) $ in Thousands | Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019
--- | --- | --- | --- | ---
Deferred tax assets: |  |  |  |
Net operating loss carryforwards | $ 84,633 | $ 71,917 |  |
Operating lease liabilities | 10,612 | 9,300 |  |
Intangible assets | 3,826 | 2,039 |  |
Accrued expenses and other current liabilities | 1,862 | 1,312 |  |
Property, plant and equipment | 510 | 971 |  |
Inventory |  | 148 |  |
Research and development tax credit carryforwards | 144 | 105 |  |
Interest carryforwards | 3,697 |  |  |
Total deferred tax assets | 105,284 | 85,792 |  |
Less valuation allowance | (74,547) | (60,289) | $ (150,113) | $ (109,856)
Deferred tax assets, net of valuation allowance | 30,737 | 25,503 |  |
Deferred tax liabilities: |  |  |  |
Acquired IPR&D Intangible Asset (see Note 3, "Corlieve transaction") | (15,033) | (15,189) |  |
Operating lease right-of-use assets | (9,323) | (7,493) |  |
Other current assets and receivables | (110) | (87) |  |
Deferred tax liability | (24,466) | (22,769) |  |
Net deferred tax asset | $ 6,271 | $ 2,734 |  |

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