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Share-based compensation - Summary of share-based compensation expense and unrecognized costs (Details) - USD ($) $ in Thousands | 1 Months Ended | 12 Months Ended
--- | --- | ---
Jun. 30, 2018 | Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2018 | Dec. 31, 2016 | Dec. 31, 2015
Share-based compensation |  |  |  |  |  |  |
Share-based compensation expense |  | $ 34,204 | $ 25,635 | $ 21,831 |  |  |
Unrecognized compensation costs |  | $ 49,528 |  |  |  |  |
Weighted-average remaining period for recognition (in years) |  | 2 years 2 months 4 days |  |  |  |  |
2014 Plan |  |  |  |  |  |  |
Share-based compensation |  |  |  |  |  |  |
Increase in authorized shares |  |  | 4,000,000 |  | 3,000,000 | 3,000,000 | 1,070,000
Authorized shares |  |  | 12,601,471 |  |  |  |
Employee share purchase plan (ESPP) |  |  |  |  |  |  |
Share-based compensation |  |  |  |  |  |  |
Share-based compensation expense |  | $ 26 | $ 28 | 43 |  |  |
Research and development expenses |  |  |  |  |  |  |
Share-based compensation |  |  |  |  |  |  |
Share-based compensation expense |  | 18,402 | 12,834 | 11,995 |  |  |
Selling, general and administrative expense |  |  |  |  |  |  |
Share-based compensation |  |  |  |  |  |  |
Share-based compensation expense |  | 15,479 | 12,801 | 9,836 |  |  |
Cost of manufacturing services revenues |  |  |  |  |  |  |
Share-based compensation |  |  |  |  |  |  |
Share-based compensation expense |  | 323 |  |  |  |  |
Share options |  |  |  |  |  |  |
Share-based compensation |  |  |  |  |  |  |
Share-based compensation expense |  | 13,425 | 12,477 | 11,434 |  |  |
Unrecognized compensation costs |  | $ 24,420 |  |  |  |  |
Weighted-average remaining period for recognition (in years) |  | 2 years 5 months 23 days |  |  |  |  |
Restricted share units ("RSUs") |  |  |  |  |  |  |
Share-based compensation |  |  |  |  |  |  |
Share-based compensation expense |  | $ 15,486 | 11,347 | 7,364 |  |  |
Unrecognized compensation costs |  | $ 24,924 |  |  |  |  |
Weighted-average remaining period for recognition (in years) |  | 1 year 10 months 24 days |  |  |  |  |
Performance Share Awards |  |  |  |  |  |  |
Share-based compensation |  |  |  |  |  |  |
Share-based compensation expense |  | $ 5,267 | $ 1,783 | $ 2,990 |  |  |
Unrecognized compensation costs |  | $ 184 |  |  |  |  |
Weighted-average remaining period for recognition (in years) |  | 1 month 20 days |  |  |  |  |
Employee Stock | Employee share purchase plan (ESPP) |  |  |  |  |  |  |
Share-based compensation |  |  |  |  |  |  |
Ordinary shares available for issue | 150,000 | 116,060 |  |  |  |  |
Discounted rate for purchase of shares | 85.00% |  |  |  |  |  |

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- Definition Amount of expense for award under share-based payment arrangement. Excludes amount capitalized. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (h)(1)(i) -URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901 + Details
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- Definition Amount of cost not yet recognized for nonvested award under share-based payment arrangement. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (i) -URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901 + Details
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- Definition Weighted-average period over which cost not yet recognized is expected to be recognized for award under share-based payment arrangement, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents reported fact of one year, five months, and thirteen days. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (i) -URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901 + Details
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- Definition Discount rate from fair value on purchase date that participants pay for shares. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901 + Details
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