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Collaboration arrangements and concentration of credit risk - CSL Behring and Bristol-Myers Squibb collaboration - Narrative (Details) $ in Thousands |  |  | 12 Months Ended
--- | --- | --- | ---
Dec. 01, 2020 USD ($) item | Jun. 24, 2020 USD ($) | Dec. 31, 2022 USD ($) item | Dec. 31, 2021 USD ($) | Dec. 31, 2020 USD ($) | Dec. 31, 2015 USD ($)
Collaboration arrangements |  |  |  |  |  |
Number of collaboration targets | item | 4 |  |  |  |  |
License revenues from related party |  |  |  |  | $ 27,800 | $ 75,100
Revenue |  |  | $ 106,483 | $ 524,002 | 37,514 |
Maximum |  |  |  |  |  |
Collaboration arrangements |  |  |  |  |  |
Collaboration agreement, additional payments receivable on achievement of commercial milestones |  |  | 1,300 |  |  |
CSL Behring collaboration. |  |  |  |  |  |
Collaboration arrangements |  |  |  |  |  |
Revenue |  |  | 100,000 |  |  |
Collaboration arrangement, variable milestone revenue not recorded |  |  | 75,000 |  |  |
Upfront cash to receive upon the closing of the agreement |  | $ 450,000 |  |  |  |
Other payments received |  | 12,400 |  |  |  |
Accounts receivable |  |  | 2,200 | 2,900 |  |
Contract asset |  |  | 100,000 | 55,000 |  |
Milestone payments to be received upon achievement |  | $ 55,000 |  |  |  |
Collaboration revenues from related party |  |  | $ 55,000 |  |  |
Number of major European Countries, Variable Milestone Revenue Not Recorded | item |  |  | 1 |  |  |
Number of Major European Countries | item |  |  | 5 |  |  |
Bristol Myers Squibb |  |  |  |  |  |
Collaboration arrangements |  |  |  |  |  |
Initial research term |  |  | 4 years |  |  |
License revenues from related parties |  |  |  |  |  |
Collaboration arrangements |  |  |  |  |  |
Revenue |  |  | $ 0 | 0 | 32,967 |
Collaboration revenues from related parties |  |  |  |  |  |
Collaboration arrangements |  |  |  |  |  |
Revenue |  |  |  |  | 136 |
Collaborative Revenue Including Revenue From Related Party |  |  |  |  |  |
Collaboration arrangements |  |  |  |  |  |
Revenue |  |  | 1,800 | 4,200 | 200 |
Contract manufacturing revenues |  |  |  |  |  |
Collaboration arrangements |  |  |  |  |  |
Revenue |  |  | 1,717 |  |  |
Contract manufacturing revenues | CSL Behring collaboration. |  |  |  |  |  |
Collaboration arrangements |  |  |  |  |  |
Revenue |  |  | $ 2,100 |  |  |
BMS arrangement |  |  |  |  |  |
Collaboration arrangements |  |  |  |  |  |
Number of collaboration targets | item |  |  | 4 |  |  |
Revenue |  |  | $ 1,752 | 4,176 | 37,514 |
BMS arrangement | CSL Behring collaboration. |  |  |  |  |  |
Collaboration arrangements |  |  |  |  |  |
Number of collaboration targets | item | 4 |  |  |  |  |
Collaboration Agreement, Period From Effective Date Collaboration Targets Can Be Replaced | 1 year |  |  |  |  |
Threshold Number Of New Collaboration Targets In The Field Of Cardiovascular Disease | item | 2 |  |  |  |  |
BMS arrangement | Bristol Myers Squibb |  |  |  |  |  |
Collaboration arrangements |  |  |  |  |  |
Initial research term |  |  | 4 years |  |  |
Number of collaboration targets | item |  |  | 4 |  |  |
Collaboration Agreement, Threshold Number Of Collaboration Targets That Can Be Replaced | item | 2 |  |  |  |  |
Revenue |  |  | $ 1,752 | 4,176 | 37,514 |
Collaboration Agreement, Threshold Research, Development And Regulatory Milestone Payments Receivable | $ 217,000 |  |  |  |  |
BMS arrangement | Bristol Myers Squibb | Maximum |  |  |  |  |  |
Collaboration arrangements |  |  |  |  |  |
Number of collaboration targets | item | 4 |  |  |  |  |
Collaborative revenue | CSL Behring collaboration. |  |  |  |  |  |
Collaboration arrangements |  |  |  |  |  |
Revenue |  |  | 3,000 | 2,400 | 0 |
Collaborative revenue | Bristol Myers Squibb |  |  |  |  |  |
Collaboration arrangements |  |  |  |  |  |
Upfront cash to receive upon the closing of the agreement |  |  |  |  | 4,400 |
Variable Consideration Due |  |  |  | 0 |  |
License revenue | CSL Behring collaboration. |  |  |  |  |  |
Collaboration arrangements |  |  |  |  |  |
Revenue |  |  | 100,000 | $ 517,400 | $ 0 |
License revenue | Bristol Myers Squibb |  |  |  |  |  |
Collaboration arrangements |  |  |  |  |  |
Maximum target designation payments to which entitled per agreement |  |  | 16,500 |  |  |
Manufacturing Development [Member] |  |  |  |  |  |
Collaboration arrangements |  |  |  |  |  |
Revenue |  |  | $ 50,000 |  |  |

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