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CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2022
Dec. 31, 2021
Dec. 31, 2020
Total revenues $ 106,483 $ 524,002 $ 37,514
Operating expenses:      
Cost of license revenues (1,254) (24,976)  
Cost of contract manufacturing revenues (2,089)    
Research and development expenses (197,591) (143,548) (122,400)
Selling, general and administrative expenses (55,059) (56,290) (42,580)
Total operating expenses (255,993) (224,814) (164,980)
Other income 7,171 12,306 3,342
Other expense (820) (876) (1,302)
(Loss) / income from operations (143,159) 310,618 (125,426)
Interest income 609 162 938
Interest expense (11,704) (7,474) (3,825)
Foreign currency gains / (losses), net 23,235 29,660 (13,613)
Other non-operating gains / (losses), net 2,760 (160) 483
(Loss) / income before income tax benefit / (expense) (128,259) 332,806 (141,443)
Income tax benefit / (expense) 1,470 (3,217) 16,419
Net (loss) / income (126,789) 329,589 (125,024)
Other comprehensive loss:      
Foreign currency translation adjustments (29,435) (38,763) 16,596
Total comprehensive (loss) / gain $ (156,224) $ 290,826 $ (108,428)
Earnings per ordinary share - basic      
Basic net (loss) / income per ordinary share $ (2.71) $ 7.17 $ (2.81)
Earnings per ordinary share - diluted      
Diluted net (loss) / income per ordinary share $ (2.71) $ 7.04 $ (2.81)
Weighted average shares - basic 46,735,045 45,986,467 44,466,365
Weighted average shares - diluted 46,735,045 46,840,972 44,466,365
License revenues      
Total revenues $ 100,000 $ 517,400 $ 4,352
License revenues from related parties      
Total revenues 0 0 32,967
Contract manufacturing revenues      
Total revenues 1,717    
Collaboration revenues      
Total revenues $ 4,766 $ 6,602 59
Collaboration revenues from related parties      
Total revenues     $ 136