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Expenses by nature (Tables)

12 Months Ended

Dec. 31, 2022

Expenses by nature

Schedule of operating expenses


		Years ended December 31,
		2022			2021			2020

		(in thousands)
Employee-related expenses		$	119,903		$	96,161		$	75,926
Laboratory and development expenses			65,964			36,014			35,977
Office and housing expenses			17,612			14,638			13,388
Legal and advisory expenses			15,782			24,767			17,370
Other operating expenses			8,510			10,528			8,772
Patent and license expenses			9,548			3,748			2,899
Depreciation and amortization expenses			8,250			7,299			10,648
Fair value loss - Corlieve contingent consideration			7,081			6,683			-
Total		$	252,650		$	199,838		$	164,980

Schedule of employee-related expenses


		Years ended December 31,
		2022			2021			2020

		(in thousands)
Wages and salaries		$	63,704		$	53,078		$	40,919
Share-based compensation expenses			33,881			25,635			21,831
Social security costs			5,179			4,496			4,068
Health insurance			4,148			3,161			2,271
Contractor expenses			3,959			3,170			2,423
Other employee expenses			6,365			4,570			2,635
Pension costs - defined contribution plans			2,667			2,051			1,779
Total		$	119,903		$	96,161		$	75,926