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Summary of significant accounting policies (Details)	12 Months Ended
	Dec. 31, 2022 USD ($) segment $ / shares	Dec. 31, 2021 USD ($)
Segment information
Number of operating segments | segment	1
Pensions
Current investment securities	$ 124,831,000
Current and non-current classification
Operating cycle period	12 months
Pension benefits | Lexington
Pensions
Amount of employer matching contribution for every employee dollar contributed	$ 0.50
Lexington. | Pension benefits
Pensions
Amount contributed to plan (in dollars per share) | $ / shares	$ 1.00
Cash and Cash Equivalents
Pensions
Current investment securities	$ 21,200,000	$ 0
Maximum | Pension benefits | Lexington
Pensions
Percent of employee gross pay for which the employer makes a matching contribution	6.00%
Leasehold improvements | Minimum
Property, plant and equipment, net
Estimated useful life (in years)	10 years
Leasehold improvements | Maximum
Property, plant and equipment, net
Estimated useful life (in years)	15 years
Laboratory equipment
Property, plant and equipment, net
Estimated useful life (in years)	5 years
Office equipment | Minimum
Property, plant and equipment, net
Estimated useful life (in years)	3 years
Office equipment | Maximum
Property, plant and equipment, net
Estimated useful life (in years)	5 years

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Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 320
-SubTopic 10
-Section 45
-Paragraph 1
-Subparagraph (b)
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