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The amount of consideration payable in development milestones through Phase I or II as at the date of acquisition.

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Number of employees employed by acquiree as at the date of acquisition.

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The cash out flow for acquisition of remaining outstanding ordinary shares related to acquisition.

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Percentage of milestones payable through the issuance of shares.

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The percentage of weighted average cost of capital.

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Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

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Percentage of voting equity interests acquired at the acquisition date in the business combination.

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The pro forma net Income or Loss for the period as if the business combination or combinations had been completed at the beginning of a period.

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Amount of equity interests of the acquirer, including instruments or interests issued or issuable in consideration for the business combination.

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Amount of liability recognized arising from contingent consideration in a business combination, expected to be settled beyond one year or the normal operating cycle, if longer.

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Corlieve transaction - Narrative (Details) $ in Thousands, € in Millions					12 Months Ended
	Sep. 30, 2021 USD ($)	Sep. 30, 2021 EUR (€)	Jul. 30, 2021 USD ($) employee Institution	Jul. 30, 2021 EUR (€)	Dec. 31, 2022 USD ($)	Dec. 31, 2022 EUR (€)	Dec. 31, 2021 USD ($)	Dec. 31, 2020	Dec. 31, 2022 EUR (€)	Jul. 30, 2021 EUR (€) employee Institution
Business Acquisition [Line Items]
Contingent consideration, net of current portion					$ 9,334		$ 29,542
Enacted tax rate					25.80%	25.80%	25.00%	25.00%
Goodwill					$ 25,581		$ 27,633
Repayment of debt acquired through acquisition of Corlieve							1,572
Acquisition of Corlieve
Business Acquisition [Line Items]
Number of institutions \| Institution			2							2
Number of employees employed \| employee			7							7
Net loss of Corlieve and its Swiss subsidiary							7,300
Net loss from Corlieve and its Swiss subsidiary included in the consolidated results							4,100
Percentage of outstanding ordinary shares			97.70%		100.00%				100.00%	97.70%
Value of shares issued			$ 53,300	€ 44.9
Contingent consideration, net of current portion			$ 24,000		$ 35,300		$ 29,500			€ 20.2
Weighted average cost of capital			10.40%							10.40%
Provisional fair value of IPR&D intangible asset			$ 63,600							€ 53.6
Deferred tax assets			1,700							1.5
Intangible assets			$ 15,900							13.4
Enacted tax rate			25.00%	25.00%
Deferred tax liability, net			$ 14,200							11.9
Goodwill			28,400							23.9
Repayment of debt acquired through acquisition of Corlieve	$ 1,200	€ 1.0	400	€ 0.4
Current assets			3,400							2.9
Cash			3,300							2.8
Current liabilities			$ 1,300							€ 1.1
Acquisition of remaining outstanding ordinary shares					1,900	€ 1.8
Acquisition of Corlieve \| Maximum
Business Acquisition [Line Items]
Consideration payable in development milestones through phase I or II					42,800				€ 40.0
Consideration payable in development milestones through phase III					$ (171,300)				€ 160.0
Percentage of milestones payable through the issuance of shares					25.00%	25.00%