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Property, plant and equipment, net - Summary of PP&E (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Property, plant and equipment, net
Total property, plant, and equipment	$ 94,658	$ 80,405
Less accumulated depreciation	(44,126)	(36,900)
Property, plant and equipment, net	50,532	43,505
Depreciation	8,200	6,100	$ 5,700
Leasehold improvements
Property, plant and equipment, net
Total property, plant, and equipment	44,871	45,372
Laboratory equipment
Property, plant and equipment, net
Total property, plant, and equipment	39,393	25,499
Office equipment
Property, plant and equipment, net
Total property, plant, and equipment	4,985	4,465
Construction-in-progress
Property, plant and equipment, net
Total property, plant, and equipment	$ 5,409	$ 5,069

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- Definition

Amount of accumulated depreciation, depletion and amortization for physical assets used in the normal conduct of business to produce goods and services.

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