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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2022
Dec. 31, 2021
Dec. 31, 2020
Cash flows from operating activities      
Net (loss) / income $ (126,789) $ 329,589 $ (125,024)
Adjustments to reconcile net (loss) / income to net cash (used in) / generated from operating activities:      
Depreciation and amortization expense 8,537 7,299 10,648
Share-based compensation expense 34,204 25,635 21,831
Deferred tax (income) / expense (1,470) 3,210 (16,419)
Changes in fair value of contingent consideration and derivative financial instrument, net 4,320 6,843 (483)
Unrealized foreign exchange (gains) / losses, net (22,083) (31,335) 14,730
Change in deferred revenue     (33,642)
Other non-cash items, net 1,605 (2,800)  
Changes in operating assets and liabilities:      
Accounts receivable, prepaid expenses, and other current assets and receivables (4,083) (3,959) (6,967)
Contract asset related to CSL Behring milestone payments (45,000) (55,000)  
Inventories (6,924)    
Accounts payable 9,238 (727) (2,701)
Accrued expenses, other liabilities, and operating leases 3,385 9,204 3,199
Net cash (used in) / generated from operating activities (145,060) 287,959 (134,828)
Cash flows from investing activities      
Investment in investment securities (163,146) 0  
Purchases of property, plant, and equipment (17,688) (17,438) (7,271)
Acquisition of Corlieve, net of cash acquired (1,900) (49,949)  
Purchases of intangible assets     (2,213)
Net cash used in investing activities (182,734) (67,387) (9,484)
Cash flows from financing activities      
Proceeds from issuance of ordinary shares related to employee stock option and purchase plans 1,445 2,798 7,444
Proceeds from loan increment, net of debt issuance costs   64,067  
Proceeds from issuance of ordinary shares   30,899  
Share issuance costs from issuance of ordinary shares   (1,334)  
Repayment of debt acquired through acquisition of Corlieve   (1,572)  
Net cash generated from financing activities 1,445 94,858 7,444
Currency effect on cash, cash equivalents and restricted cash (1,831) (3,757) 3,822
Net (decrease) / increase in cash, cash equivalents and restricted cash (328,180) 311,673 (133,046)
Cash, cash equivalents and restricted cash at beginning of period 559,353 247,680 380,726
Cash, cash equivalents and restricted cash at the end of period 231,173 559,353 247,680
Cash and cash equivalents 228,012 556,256 244,932
Restricted cash related to leasehold and other deposits 3,161 3,097 2,748
Total cash, cash equivalents and restricted cash 231,173 559,353 247,680
Supplemental cash flow disclosures:      
Cash paid for interest (9,247) (6,539) (4,131)
Non-cash (decrease) / increase in accounts payables and accrued expenses and other current liabilities related to purchases of property, plant, and equipment $ (964) $ 1,488 $ 630