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The increase in maximum number of common shares permitted to be issued by an entity's charter and bylaws.

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The amount of net proceeds from the issue of shares.

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Percentage of gross proceeds of shares sold.

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Accumulated change in equity from transactions and other events and circumstances from non-owner sources, net of tax effect, at period end. Excludes Net Income (Loss), and accumulated changes in equity from transactions resulting from investments by owners and distributions to owners. Includes foreign currency translation items, certain pension adjustments, unrealized gains and losses on certain investments in debt and equity securities, other than temporary impairment (OTTI) losses related to factors other than credit losses on available-for-sale and held-to-maturity debt securities that an entity does not intend to sell and it is not more likely than not that the entity will be required to sell before recovery of the amortized cost basis, as well as changes in the fair value of derivatives related to the effective portion of a designated cash flow hedge.

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Amount of decrease in additional paid in capital (APIC) resulting from direct costs associated with issuing stock. Includes, but is not limited to, legal and accounting fees and direct costs associated with stock issues under a shelf registration.

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Face amount or stated value per share of common stock.

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Foreign exchange rate used to translate amounts denominated in functional currency to reporting currency.

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Number of new stock issued during the period.

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Shareholder's equity (Details) € / shares in Units, $ / shares in Units, € in Millions		2 Months Ended	12 Months Ended
	Mar. 01, 2021 USD ($)	Apr. 30, 2021 USD ($) $ / shares shares	Dec. 31, 2022 USD ($) $ / € shares	Dec. 31, 2021 USD ($)	Dec. 31, 2022 EUR (€) € / shares $ / € shares	Dec. 31, 2021 € / shares	Dec. 31, 2021 USD ($) shares	Jun. 16, 2021 shares	Dec. 31, 2020 USD ($)
Authorized share capital			$ 4,300,000		€ 4.0
Common stock, additional shares authorized \| shares								20,000,000
Exchange rate (in USD per Euro) \| $ / €			1.07		1.07
Ordinary shares, authorized \| shares			80,000,000		80,000,000		80,000,000
Ordinary shares, par value (in euros per share) \| € / shares					€ 0.05	€ 0.05
Accumulated other comprehensive loss			$ (58,291,000)				$ (28,856,000)		$ (9,900,000)
Aggregate offering price				$ 29,564,000
Income tax benefit of past share issuance cost			808,000	3,047,000
Increase of additional paid in capital			800,000
Sales Agreement with SVB Leerink LLC
Percentage of gross proceeds	3.00%
Sales Agreement with SVB Leerink LLC \| Direct Incremental Labor
Adjustments to Additional Paid in Capital, Stock Issued, Issuance Costs			$ 0	$ 1,300,000
Sales Agreement with SVB Leerink LLC \| Ordinary shares
Shares issued in connection with offering \| shares		921,730
Share price (in dollars per share) \| $ / shares		$ 33.52
Net proceeds		$ 29,600,000
Sales Agreement with SVB Leerink LLC \| Maximum
Aggregate offering price	$ 200,000,000.0