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Share-based compensation - Summary of share-based compensation expense and unrecognized costs (Details) - USD ($) $ in Thousands	1 Months Ended	12 Months Ended
	Jun. 30, 2018	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2018	Dec. 31, 2016	Dec. 31, 2015
Share-based compensation
Share-based compensation expense		$ 34,204	$ 25,635	$ 21,831
Unrecognized compensation costs		$ 49,528
Weighted-average remaining period for recognition (in years)		2 years 2 months 4 days
2014 Plan
Share-based compensation
Increase in authorized shares			4,000,000		3,000,000	3,000,000	1,070,000
Authorized shares			12,601,471
Employee share purchase plan (ESPP)
Share-based compensation
Share-based compensation expense		$ 26	$ 28	43
Research and development expenses
Share-based compensation
Share-based compensation expense		18,402	12,834	11,995
Selling, general and administrative expense
Share-based compensation
Share-based compensation expense		15,479	12,801	9,836
Cost of manufacturing services revenues
Share-based compensation
Share-based compensation expense		323
Share options
Share-based compensation
Share-based compensation expense		13,425	12,477	11,434
Unrecognized compensation costs		$ 24,420
Weighted-average remaining period for recognition (in years)		2 years 5 months 23 days
Restricted share units ("RSUs")
Share-based compensation
Share-based compensation expense		$ 15,486	11,347	7,364
Unrecognized compensation costs		$ 24,924
Weighted-average remaining period for recognition (in years)		1 year 10 months 24 days
Performance Share Awards
Share-based compensation
Share-based compensation expense		$ 5,267	$ 1,783	$ 2,990
Unrecognized compensation costs		$ 184
Weighted-average remaining period for recognition (in years)		1 month 20 days
Employee Stock | Employee share purchase plan (ESPP)
Share-based compensation
Ordinary shares available for issue	150,000	116,060
Discounted rate for purchase of shares	85.00%

X

- Definition

Amount of expense for award under share-based payment arrangement. Excludes amount capitalized.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section 50
-Paragraph 2
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Amount of cost not yet recognized for nonvested award under share-based payment arrangement.

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Weighted-average period over which cost not yet recognized is expected to be recognized for award under share-based payment arrangement, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents reported fact of one year, five months, and thirteen days.

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- Definition

Discount rate from fair value on purchase date that participants pay for shares.

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The difference between the maximum number of shares (or other type of equity) authorized for issuance under the plan (including the effects of amendments and adjustments), and the sum of: 1) the number of shares (or other type of equity) already issued upon exercise of options or other equity-based awards under the plan; and 2) shares (or other type of equity) reserved for issuance on granting of outstanding awards, net of cancellations and forfeitures, if applicable.

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