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Share-based compensation - Option activity and weighted-average assumptions (Details) - USD ($)
$ / shares in Units, $ in Thousands
12 Months Ended
Dec. 31, 2022
Dec. 31, 2021
Dec. 31, 2020
Weighted average exercise price      
Proceeds from Issuance of Shares under Incentive and Share-based Compensation Plans, Including Stock Options $ 1,445 $ 2,798 $ 7,444
2014 Plan      
Options      
Thereof, outstanding and expected to vest after at end of period (in shares) 2,098,557 1,521,500  
Weighted average exercise price      
Outstanding and expected to vest after at end of the period (in dollars per share) $ 13.46 $ 22.52  
Total weighted average grant date fair value of options issued during the period (in $ millions) $ 12,900    
Proceeds from Issuance of Shares under Incentive and Share-based Compensation Plans, Including Stock Options $ 1,300    
Vesting period (in years) 4 years    
Weighted-average assumptions used to estimate fair value of share options granted during year      
Expected volatility (as a percent) 70.00% 75.00% 70.00%
Expected terms (in years) 10 years 10 years 10 years
Risk free interest rate, minimum (as a percent) 2.12% 1.21% 0.76%
Risk free interest rate, maximum (as a percent) 4.16% 1.86% 1.44%
Expected dividend (as a percent) 0.00% 0.00% 0.00%
2014 Plan | Minimum      
Weighted-average assumptions used to estimate fair value of share options granted during year      
Expected volatility (as a percent)     70.00%
2014 Plan | Share options      
Options      
Outstanding at beginning of the period (in shares) 3,308,325    
Granted (in shares) 1,426,966 1,174,893 653,852
Forfeited (in shares) (204,224)    
Expired (in shares) (154,794)    
Exercised (in shares) (138,356) (241,496) (498,678)
Outstanding at end of the period (in shares) 4,237,917 3,308,325  
Thereof, fully vested and exercisable at end of period (in shares) 2,139,360    
Thereof, outstanding and expected to vest after at end of period (in shares) 2,098,557 1,521,500  
Weighted average exercise price      
Outstanding at beginning of the period (in dollars per share) $ 31.02    
Granted (in dollars per share) 15.90    
Forfeited (in dollars per share) 38.29    
Expired (in dollars per share) 36.86    
Exercised (in dollars per share) 7.81    
Outstanding at end of period (in dollars per share) 26.13 $ 31.02  
Thereof, fully vested and exercisable at end of period (in dollars per share) 28.82    
Outstanding and expected to vest after at end of the period (in dollars per share) $ 23.38 $ 38.71  
Weighted average remaining contractual life (in years)      
Outstanding 7 years 1 month 20 days 7 years 18 days  
Thereof, fully vested and exercisable at end of year 5 years 5 months 12 days    
Outstanding and expected to vest at end of year 8 years 10 months 9 days    
Aggregate intrinsic value      
Outstanding (in dollars) $ 17,848 $ 8,660  
Thereof, fully vested and exercisable 8,339    
Outstanding and expected to vest 9,509    
Exercised (in dollars) $ 1,848 $ 5,046 $ 11,927
Weighted average grant-date fair value      
Vested (in shares) 652,635    
Forfeited (in dollar per share) $ 22.17    
2014 Plan | Non-executive directors      
Weighted average exercise price      
Vesting period (in years) 1 year    
2014 Plan | Directors and Officers      
Options      
Granted (in shares) 672,908    
Weighted average exercise price      
Granted (in dollars per share) $ 5.9    
2014 Plan | One year from grant date      
Weighted average exercise price      
Vesting percentage per year 25.00%    
Vesting period (in years) 1 year    
2012 Plan      
Options      
Outstanding at beginning of the period (in shares) 14,000    
Outstanding at end of the period (in shares) 0 14,000