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Expenses by nature - Employee-related expenses (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Employee-related expenses
Wages and salaries	$ 63,704	$ 53,078	$ 40,919
Share-based compensation expenses	33,881	25,635	21,831
Social security costs	5,179	4,496	4,068
Health insurance	4,148	3,161	2,271
Contractor expenses	3,959	3,170	2,423
Other employee expenses	6,365	4,570	2,635
Pension costs - defined contribution plans	2,667	2,051	1,779
Total	$ 119,903	$ 96,161	$ 75,926

X

- Definition

Amount of contractor expenses incurred during the period and charged to earnings.

+ References

No definition available.

+ Details

Name:	qure_ContractorExpenses
Namespace Prefix:	qure_
Data Type:	xbrli:monetaryItemType
Balance Type:	debit
Period Type:	duration

X

- Definition

Amount of health insurance incurred during the period and charged to earnings.

+ References

No definition available.

+ Details

Name:	qure_HealthInsurance
Namespace Prefix:	qure_
Data Type:	xbrli:monetaryItemType
Balance Type:	debit
Period Type:	duration

X

- Definition

Represents the share based compensation expense in employee benefits.

+ References

No definition available.

+ Details

Name:	qure_ShareBasedCompensationInEmployeeBenefits
Namespace Prefix:	qure_
Data Type:	xbrli:monetaryItemType
Balance Type:	debit
Period Type:	duration

X

- Definition

Amount of social security costs incurred during the period and charged to earnings.

+ References

No definition available.

+ Details

Name:	qure_SocialSecurityCosts
Namespace Prefix:	qure_
Data Type:	xbrli:monetaryItemType
Balance Type:	debit
Period Type:	duration

X

- Definition

Amount of expense for salary, wage, profit sharing; incentive and equity-based compensation; and other employee benefit.

+ References

Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 220
-SubTopic 10
-Section S99
-Paragraph 2
-Subparagraph (SX 210.5-03(b)(4))
-URI https://asc.fasb.org/extlink&oid=126953954&loc=SL114868664-224227

+ Details

Name:	us-gaap_LaborAndRelatedExpense
Namespace Prefix:	us-gaap_
Data Type:	xbrli:monetaryItemType
Balance Type:	debit
Period Type:	duration

X

- References

No definition available.

+ Details

Name:	us-gaap_LaborAndRelatedExpenseAbstract
Namespace Prefix:	us-gaap_
Data Type:	xbrli:stringItemType
Balance Type:	na
Period Type:	duration

X

- Definition

Amount of labor-related expenses classified as other.

+ References

Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 220
-SubTopic 10
-Section S99
-Paragraph 2
-Subparagraph (SX 210.5-03.4)
-URI https://asc.fasb.org/extlink&oid=126953954&loc=SL114868664-224227

+ Details

Name:	us-gaap_OtherLaborRelatedExpenses
Namespace Prefix:	us-gaap_
Data Type:	xbrli:monetaryItemType
Balance Type:	debit
Period Type:	duration

X

- Definition

Amount of cost (reversal of cost) for pension and other postretirement benefits.

+ References

No definition available.

+ Details

Name:	us-gaap_PensionAndOtherPostretirementBenefitExpense
Namespace Prefix:	us-gaap_
Data Type:	xbrli:monetaryItemType
Balance Type:	debit
Period Type:	duration

X

- Definition

Amount of expense for salary and wage arising from service rendered by nonofficer and officer employees. Excludes allocated cost, labor-related nonsalary expense, and direct and overhead labor cost included in cost of good and service sold.

+ References

No definition available.

+ Details

Name:	us-gaap_SalariesWagesAndOfficersCompensation
Namespace Prefix:	us-gaap_
Data Type:	xbrli:monetaryItemType
Balance Type:	debit
Period Type:	duration