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Royalty financing agreement (Details) $ in Thousands |  | 3 Months Ended |  |
--- | --- | --- | --- | ---
May 12, 2023 USD ($) | Mar. 31, 2024 USD ($) | Mar. 31, 2023 USD ($) | Dec. 31, 2038 | Jun. 30, 2032 USD ($)
Collaboration arrangements |  |  |  |  |
Royalty financing agreement interest expense |  | $ 12,362 |  |  |
Interest Expense |  | 16,097 | $ 3,562 |  |
CLS |  |  |  |  |
Collaboration arrangements |  |  |  |  |
Maximum rights to all other royalties, as well as contractual milestones retained |  | 1,300,000 |  |  |
Royalty financing agreement |  |  |  |  |
Collaboration arrangements |  |  |  |  |
Upfront payment received | $ 375,000 |  |  |  |
Additional milestone payment | $ 25,000 |  |  |  |
Ratio of upfront payment | 1.85 |  |  |  |
Upfront payment payable to purchaser | $ 693,800 | 693,800 |  |  |
Royalty financing agreement interest expense |  | 12,362 |  |  |
Net proceeds from the Royalty Financing Agreement |  | 370,100 |  |  |
Payment of debt issuance costs |  | 4,900 |  |  |
Interest Expense |  | $ 12,400 | $ 0 |  |
Royalty financing agreement | Minimum |  |  |  |  |
Collaboration arrangements |  |  |  |  |
Effective interest rate (as a percent) |  | 12.00% |  |  |
Interest Expense |  | $ 12,100 |  |  |
Royalty financing agreement | Maximum |  |  |  |  |
Collaboration arrangements |  |  |  |  |
Effective interest rate (as a percent) |  | 13.50% |  |  |
Interest Expense |  | $ 13,700 |  |  |
Royalty financing agreement | First Hard Cap Date |  |  |  |  |
Collaboration arrangements |  |  |  |  |
Ratio of upfront payment |  |  |  |  | 1.85
Upfront payment payable to purchaser |  |  |  |  | $ 25,000
Royalty financing agreement interest expense |  | 323,700 |  |  |
Royalty financing agreement | If paid through December 31, 2038 |  |  |  |  |
Collaboration arrangements |  |  |  |  |
Ratio of upfront payment |  |  |  | 2.25 |
Royalty financing agreement | If 2024 net sales do not exceed a pre-specified threshold |  |  |  |  |
Collaboration arrangements |  |  |  |  |
Upfront payment payable to purchaser |  | $ 25,000 |  |  |

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