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UNAUDITED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 3 Months Ended
--- | ---
Mar. 31, 2024 | Mar. 31, 2023
Cash flows from operating activities |  |
Net loss | $ (65,618) | $ (77,227)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Depreciation and amortization | 2,629 | 2,527
Amortization of discount on investment securities | (3,695) | (925)
Share-based compensation expense | 7,191 | 8,061
Royalty financing agreement interest expense | 12,362 |
Deferred tax expense / (income) | 656 | (1,207)
Changes in fair value of contingent consideration | 165 | 975
Unrealized foreign exchange losses, net | 1,389 | 1,193
Other items, net | 2,778 | 456
Changes in operating assets and liabilities: |  |
Accounts receivable, prepaid expenses, and other current assets and receivables | (10,417) | (936)
Inventories | 2,236 | (553)
Accounts payable | (701) | (1,661)
Accrued expenses, other liabilities, and operating leases | (9,550) | (9,005)
Net cash used in operating activities | (60,575) | (78,302)
Cash flows from investing activities |  |
Proceeds on maturity of debt securities | 150,107 | 5,330
Investment in debt securities | (83,778) |
Purchases of property, plant, and equipment | (2,344) | (2,342)
Net cash generated from investing activities | 63,985 | 2,988
Cash flows from financing activities |  |
Proceeds from issuance of ordinary shares related to employee stock option and purchase plans |  | 131
Net cash generated from financing activities |  | 131
Currency effect on cash, cash equivalents and restricted cash | (1,725) | 1,034
Net increase / (decrease) in cash, cash equivalents and restricted cash | 1,685 | (74,149)
Cash, cash equivalents and restricted cash at beginning of period | 244,544 | 231,173
Cash, cash equivalents and restricted cash at the end of period | 246,229 | 157,024
Cash and cash equivalents | 243,062 | 153,851
Restricted cash related to leasehold and other deposits | 3,167 | 3,173
Total cash, cash equivalents and restricted cash | 246,229 | 157,024
Supplemental cash flow disclosures: |  |
Cash paid for interest | (4,761) | (3,057)
Non-cash decrease in accounts payables and accrued expenses and other current liabilities related to purchases of property, plant, and equipment | $ (577) | $ (753)

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