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Share-based compensation - Summary of share-based compensation expense and unrecognized costs (Details) - USD ($) $ in Thousands	1 Months Ended	3 Months Ended
	Jun. 30, 2018	Mar. 31, 2024	Mar. 31, 2023
Share-based compensation
Authorized shares		14
2014 Plan
Share-based compensation
Authorized shares		14
Share-based compensation expense		$ 7,191	$ 8,061
Unrecognized compensation costs		$ 48,804
Weighted-average remaining period for recognition (in years)		2 years 2 months 23 days
2014 Plans and ESPP
Share-based compensation
Share-based compensation expense		$ 7,191	8,061
Research and development expenses | 2014 Plans and ESPP
Share-based compensation
Share-based compensation expense		3,425	4,305
Selling, general and administrative expense | 2014 Plans and ESPP
Share-based compensation
Share-based compensation expense		3,421	3,732
Cost of manufacturing services revenues | 2014 Plans and ESPP
Share-based compensation
Share-based compensation expense		345	24
Share options | 2014 Plan
Share-based compensation
Unrecognized compensation costs		$ 20,743
Weighted-average remaining period for recognition (in years)		2 years 6 months 21 days
Share options | 2014 Plans and ESPP
Share-based compensation
Share-based compensation expense		$ 2,913	3,274
Restricted share units ("RSUs") | 2014 Plan
Share-based compensation
Unrecognized compensation costs		$ 27,981
Weighted-average remaining period for recognition (in years)		1 year 11 months 26 days
Restricted share units ("RSUs") | 2014 Plans and ESPP
Share-based compensation
Share-based compensation expense		$ 4,370	4,630
Performance Share Awards | 2014 Plan
Share-based compensation
Unrecognized compensation costs		$ 80
Weighted-average remaining period for recognition (in years)		7 months 9 days
Performance Share Awards | 2014 Plans and ESPP
Share-based compensation
Share-based compensation expense		$ (99)	$ 150
Employee share purchase plan | Employee share purchase plan (ESPP)
Share-based compensation
Ordinary shares available for issue	150,000	96,862	113,565
Discounted rate for purchase of shares	85.00%
Employee share purchase plan | 2014 Plans and ESPP
Share-based compensation
Share-based compensation expense		$ 7	$ 7

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