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UNAUDITED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands
 3 Months Ended
Mar. 31, 2024
Mar. 31, 2023
Cash flows from operating activities    
Net loss $ (65,618) $ (77,227)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 2,629 2,527
Amortization of discount on investment securities (3,695) (925)
Share-based compensation expense 7,191 8,061
Royalty financing agreement interest expense 12,362  
Deferred tax expense / (income) 656 (1,207)
Changes in fair value of contingent consideration 165 975
Unrealized foreign exchange losses, net 1,389 1,193
Other items, net 2,778 456
Changes in operating assets and liabilities:    
Accounts receivable, prepaid expenses, and other current assets and receivables (10,417) (936)
Inventories 2,236 (553)
Accounts payable (701) (1,661)
Accrued expenses, other liabilities, and operating leases (9,550) (9,005)
Net cash used in operating activities (60,575) (78,302)
Cash flows from investing activities    
Proceeds on maturity of debt securities 150,107 5,330
Investment in debt securities (83,778)  
Purchases of property, plant, and equipment (2,344) (2,342)
Net cash generated from investing activities 63,985 2,988
Cash flows from financing activities    
Proceeds from issuance of ordinary shares related to employee stock option and purchase plans   131
Net cash generated from financing activities   131
Currency effect on cash, cash equivalents and restricted cash (1,725) 1,034
Net increase / (decrease) in cash, cash equivalents and restricted cash 1,685 (74,149)
Cash, cash equivalents and restricted cash at beginning of period 244,544 231,173
Cash, cash equivalents and restricted cash at the end of period 246,229 157,024
Cash and cash equivalents 243,062 153,851
Restricted cash related to leasehold and other deposits 3,167 3,173
Total cash, cash equivalents and restricted cash 246,229 157,024
Supplemental cash flow disclosures:    
Cash paid for interest (4,761) (3,057)
Non-cash decrease in accounts payables and accrued expenses and other current liabilities related to purchases of property, plant, and equipment $ (577) $ (753)