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Commitments and Contingencies (Details) - USD ($) $ in Thousands |  | 1 Months Ended | 12 Months Ended |
--- | --- | --- | --- | ---
Oct. 05, 2020 | Nov. 30, 2019 | Feb. 28, 2018 | Dec. 31, 2021 | Dec. 31, 2020 | Mar. 31, 2015
Leased assets |  |  |  |  |  |
Rent for facility lease |  |  |  | $ 8,600 | $ 3,200 |
Letter of credit |  |  |  | 2,500 |  |
Sublease income |  |  |  | 2,300 |  |
Lease Cost: |  |  |  |  |  |
Operating lease cost |  |  |  | 8,642 |  |
Variable lease cost |  |  |  | 2,256 |  |
Total lease cost |  |  |  | 10,898 |  |
Operating cash flows used for operating leases |  |  |  | $ 8,880 |  |
Weighted average remaining lease term |  |  |  | 3 years 4 months 24 days |  |
Weighted average incremental borrowing rate |  |  |  | 7.50% |  |
Payment made on commitment |  |  |  | $ 2,000 |  |
Payment commitment |  |  |  | 3,700 |  |
Antibody library expense |  |  |  | $ 3,700 |  |
620 Memorial Drive, Cambridge MA |  |  |  |  |  |
Leased assets |  |  |  |  |  |
Term of lease |  |  |  |  |  | 5 years
Option to extend the term |  |  | true |  |  |
Renewal term |  |  | 5 years |  |  |
Sublease annual base rent | $ 1,900 |  |  |  |  |
620 Memorial Drive, Cambridge MA | Financing receivable, lower range of payment terms |  |  |  |  |  |
Leased assets |  |  |  |  |  |
Rent for facility lease |  |  | $ 1,400 |  |  |
620 Memorial Drive, Cambridge MA | Financing receivable, upper range of payment terms |  |  |  |  |  |
Leased assets |  |  |  |  |  |
Rent for facility lease |  |  | $ 1,700 |  |  |
301 Binney St, Cambridge MA |  |  |  |  |  |
Leased assets |  |  |  |  |  |
Option to extend the term |  | true |  |  |  |
Renewal term |  | 2 years |  |  |  |
Base rent |  | $ 6,900 |  |  |  |
Annual upward adjustment (as a percent) |  | 3.50% |  |  |  |
Incentive to lease |  | $ 14,100 |  |  |  |
Letter of credit |  | $ 2,300 |  |  |  |

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- Definition Amount of single lease cost, calculated by allocation of remaining cost of lease over remaining lease term. Includes, but is not limited to, single lease cost, after impairment of right-of-use asset, calculated by amortization of remaining right-of-use asset and accretion of lease liability. + References Reference 1: http://www.xbrl.org/2003/role/exampleRef -Publisher FASB -Name Accounting Standards Codification -Topic 842 -SubTopic 20 -Section 55 -Paragraph 53 -URI http://asc.fasb.org/extlink&oid=123414884&loc=SL77918982-209971 Reference 2: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 842 -SubTopic 20 -Section 50 -Paragraph 4 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=123408670&loc=SL77918686-209980 + Details
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- Definition Minimum amount of other commitment not otherwise specified in the taxonomy. Excludes commitments explicitly modeled in the taxonomy, including but not limited to, long-term and short-term purchase commitments, recorded and unrecorded purchase obligations, supply commitments, registration payment arrangements, leases, debt, product warranties, guarantees, environmental remediation obligations, and pensions. + References No definition available. + Details
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- Definition The costs incurred in a planned search or critical investigation aimed at discovery of new knowledge with the hope that such knowledge will be useful in developing a new product or service, a new process or technique, or in bringing about a significant improvement to an existing product or process; or to translate research findings or other knowledge into a plan or design for a new product or process or for a significant improvement to an existing product or process whether intended for sale or the entity's use, during the reporting period charged to research and development projects, excluding in-process research and development acquired in a business combination consummated during the period. Excludes software research and development, which has a separate concept. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 730 -SubTopic 10 -Section 50 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=6420194&loc=d3e21568-108373 + Details
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