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Net Loss per Share (Details) - shares	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020
Anti-dilutive securities
Pre funded warrants exercised during period	0
Anti-dilutive securities excluded from the calculation of net loss per share	4,058,301	3,737,900
Restricted stock awards
Anti-dilutive securities
Anti-dilutive securities excluded from the calculation of net loss per share		57,969
Restricted Stock Units
Anti-dilutive securities
Anti-dilutive securities excluded from the calculation of net loss per share	314,901
Stock Options
Anti-dilutive securities
Anti-dilutive securities excluded from the calculation of net loss per share	3,743,400	3,679,931

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Number of pre-funded warrants exercised during the period

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Securities (including those issuable pursuant to contingent stock agreements) that could potentially dilute basic earnings per share (EPS) or earnings per unit (EPU) in the future that were not included in the computation of diluted EPS or EPU because to do so would increase EPS or EPU amounts or decrease loss per share or unit amounts for the period presented.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 260
-SubTopic 10
-Section 50
-Paragraph 1
-Subparagraph (c)
-URI http://asc.fasb.org/extlink&oid=124432515&loc=d3e3550-109257

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