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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands
 6 Months Ended
Jun. 30, 2023
Jun. 30, 2022
Cash flows from operating activities:    
Net loss $ (77,304) $ (51,950)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 1,464 1,493
Amortization of debt discount and debt issuance costs 157 389
Loss on disposal of property and equipment   32
Equity-based compensation 12,988 13,619
Amortization/accretion of investment securities (2,563) 291
Non-cash operating lease expense 3,658 3,382
Change in operating assets and liabilities:    
Prepaid expenses and other current assets 1,571 (6,126)
Other assets 117 (62)
Accounts payable (950) (1,394)
Accrued expenses (10,516) 17
Operating lease liabilities (4,144) (3,571)
Deferred revenue   (33,193)
Other liabilities (82) (231)
Net cash used in operating activities (75,604) (77,304)
Cash flows from investing activities:    
Purchases of property and equipment (71) (920)
Proceeds from sale of property and equipment 13  
Purchases of marketable securities (105,200) (80,134)
Maturities of marketable securities 180,000 55,000
Net cash provided by (used in) investing activities 74,742 (26,054)
Cash flows from financing activities:    
Proceeds from sale of common shares, pre-funded warrants and warrants to purchase common shares, net of issuance costs 5,223 195,770
Proceeds from stock option exercises 539 483
Other 3  
Net cash provided by financing activities 5,765 196,253
Net increase in cash, cash equivalents and restricted cash 4,903 92,895
Cash, cash equivalents and restricted cash, beginning of period 105,773 215,333
Cash, cash equivalents and restricted cash, end of period 110,676 308,228
Supplemental disclosure of non-cash items:    
Offering costs in accrued expenses   445
Supplemental cash flow information:    
Cash paid for interest $ 3,090 $ 1,836