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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands
 9 Months Ended
Sep. 30, 2024
Sep. 30, 2023
Cash flows from operating activities:    
Net loss $ (179,840) $ (119,663)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 1,542 2,172
Amortization of debt discount and debt issuance costs 206 215
Equity-based compensation 27,126 20,191
Amortization/accretion of investment securities (3,945) (4,417)
Non-cash operating lease expense 4,034 5,546
Change in operating assets and liabilities:    
Prepaid expenses and other current assets (5,734) 2,817
Other assets 608 387
Accounts payable 606 (2,026)
Accrued expenses 8,821 (6,924)
Operating lease liabilities (4,744) (6,117)
Other liabilities (116) (58)
Net cash used in operating activities (151,436) (107,877)
Cash flows from investing activities:    
Purchases of property and equipment (76) (71)
Proceeds from sale of property and equipment   13
Purchases of marketable securities (82,710) (186,673)
Maturities of marketable securities 202,100 253,000
Net cash provided by investing activities 119,314 66,269
Cash flows from financing activities:    
Proceeds from sale of common shares, net of issuance costs   5,223
Proceeds from pre-funded and common warrant exercises 6,106  
Debt modification payment (125)  
Proceeds from stock option exercises 677 819
Other   3
Net cash provided by financing activities 6,658 6,045
Net decrease in cash, cash equivalents and restricted cash (25,464) (35,563)
Cash, cash equivalents and restricted cash, beginning of period 104,262 105,773
Cash, cash equivalents and restricted cash, end of period 78,798 70,210
Supplemental disclosure of non-cash items:    
Property and equipment purchases in accounts payable & accrued expenses 22  
Operating lease liability, adjustment from rent modification 9,451  
Supplemental cash flow information:    
Cash paid for interest $ 5,003 $ 4,743