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Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($)
$ in Thousands
3 Months Ended 6 Months Ended 18 Months Ended
Jun. 30, 2026
Jun. 30, 2025
Jun. 30, 2026
Jun. 30, 2025
Jun. 30, 2026
Cash flows from operating activities          
Net loss     $ (286,347) $ (111,190)  
Adjustments to reconcile net loss to net cash used in operating activities          
Amortization of investment premiums     (2,178) (5,524)  
Amortization of financing costs $ 0 $ 24 0 48  
Stock-based compensation 11,133 13,547 21,470 24,895  
Amortization of right-of-use assets     242 223  
Realized gain on investments (30) (4) (30) (4)  
Interest expense related to operating lease liability     112 18  
Changes in operating assets and liabilities:          
Prepaid expenses and other current assets     (6,108) (14,643)  
Accrued interest, net of interest receivable on maturity of investments     1,056 2,459  
Accounts payable     15,761 (4,319)  
Accrued expenses     17,204 8,904  
Lease liability     (330) (259)  
Net cash used in operating activities     (239,148) (99,392)  
Cash flows from investing activities          
Purchases of investments     (142,491) (356,090)  
Proceeds from sales of investments     38,466 0  
Proceeds from maturities of investments     267,645 461,841  
Net cash provided by investing activities     163,620 105,751  
Cash flows from financing activities          
Proceeds from exercises of stock options and other stock issuances     1,463 856  
ATM offering, net of fees     34,200 0  
Net cash provided by financing activities     35,663 856  
Net (decrease) increase in cash, cash equivalents and restricted cash     (39,865) 7,215  
Cash, cash equivalents and restricted cash beginning of period     165,810 26,676 $ 26,676
Effect of exchange rate changes on cash     16 (11)  
Cash, cash equivalents and restricted cash at end of period $ 125,961 $ 33,880 125,961 33,880 $ 125,961
Supplemental disclosure of non-cash investing and financing transactions          
Unpaid deferred public offering and other financing costs     50 50  
Right-of-use asset obtained in exchange for lease obligation     $ 4,180 $ 0