<SEC-DOCUMENT>0001964306-25-000374.txt : 20251014
<SEC-HEADER>0001964306-25-000374.hdr.sgml : 20251014
<ACCEPTANCE-DATETIME>20251014100917
ACCESSION NUMBER:		0001964306-25-000374
CONFORMED SUBMISSION TYPE:	144
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20251014
DATE AS OF CHANGE:		20251014

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Mineralys Therapeutics, Inc.
		CENTRAL INDEX KEY:			0001933414
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		EIN:				000000000
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		144
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	001-41614
		FILM NUMBER:		251390230

	BUSINESS ADDRESS:	
		STREET 1:		150 N. RADNOR CHESTER ROAD
		STREET 2:		SUITE F200
		CITY:			RADNOR
		STATE:			PA
		ZIP:			19087
		BUSINESS PHONE:		(888) 378-6240

	MAIL ADDRESS:	
		STREET 1:		150 N. RADNOR CHESTER ROAD
		STREET 2:		SUITE F200
		CITY:			RADNOR
		STATE:			PA
		ZIP:			19087

REPORTING-OWNER:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Congleton Jon
		CENTRAL INDEX KEY:			0001644975
		ORGANIZATION NAME:           	

	FILING VALUES:
		FORM TYPE:		144

	MAIL ADDRESS:	
		STREET 1:		3122 STERLING CIRCLE, SUITE 200
		CITY:			BOULDER
		STATE:			CO
		ZIP:			80301
</SEC-HEADER>
<DOCUMENT>
<TYPE>144
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
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      <filer>
        <filerCredentials>
          <cik>0001644975</cik>
          <ccc>XXXXXXXX</ccc>
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    <issuerInfo>
      <issuerCik>0001933414</issuerCik>
      <issuerName>Mineralys Therapeutics, Inc.</issuerName>
      <secFileNumber>001-41614</secFileNumber>
      <issuerAddress>
        <com:street1>150 N. RADNOR CHESTER ROAD</com:street1>
        <com:street2>SUITE F200</com:street2>
        <com:city>RADNOR</com:city>
        <com:stateOrCountry>PA</com:stateOrCountry>
        <com:zipCode>19087</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>(888) 378-6240</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Congleton Jon</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
        <relationshipToIssuer>Director</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Merrill Lynch</name>
        <address>
          <com:street1>225 Liberty St</com:street1>
          <com:street2>Floor 37</com:street2>
          <com:city>New York</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10281</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>15100</noOfUnitsSold>
      <aggregateMarketValue>644326.47</aggregateMarketValue>
      <noOfUnitsOutstanding>66295184</noOfUnitsOutstanding>
      <approxSaleDate>10/13/2025</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <acquiredDate>10/10/2025</acquiredDate>
      <natureOfAcquisitionTransaction>Vesting of restricted stock unit award</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Mineralys Therapeutics, Inc.</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>15100</amountOfSecuritiesAcquired>
      <paymentDate>10/10/2025</paymentDate>
      <natureOfPayment>Granted as part of issuer equity compensation plan</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>10/13/2025</noticeDate>
      <planAdoptionDates>
        <planAdoptionDate>01/30/2024</planAdoptionDate>
      </planAdoptionDates>
      <signature>Jon Congleton</signature>
    </noticeSignature>
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