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      <link:roleType id="InventoriesDetails" roleURI="http://www.prestigebrandsinc.com/role/InventoriesDetails">
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        <link:usedOn>link:calculationLink</link:usedOn>
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        <link:usedOn>link:calculationLink</link:usedOn>
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      <link:roleType id="LeasesLeaseCostDetails" roleURI="http://www.prestigebrandsinc.com/role/LeasesLeaseCostDetails">
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        <link:usedOn>link:calculationLink</link:usedOn>
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        <link:usedOn>link:calculationLink</link:usedOn>
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      <link:roleType id="LeasesAdditionalInformationDetails" roleURI="http://www.prestigebrandsinc.com/role/LeasesAdditionalInformationDetails">
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        <link:usedOn>link:calculationLink</link:usedOn>
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      <link:roleType id="LeasesNarrativeDetails" roleURI="http://www.prestigebrandsinc.com/role/LeasesNarrativeDetails">
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        <link:usedOn>link:calculationLink</link:usedOn>
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      <link:roleType id="OtherAccruedLiabilitiesDetails" roleURI="http://www.prestigebrandsinc.com/role/OtherAccruedLiabilitiesDetails">
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        <link:usedOn>link:calculationLink</link:usedOn>
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        <link:definition>9954514 - Disclosure - Long-Term Debt (Schedule of Long-term Debt) (Details)</link:definition>
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        <link:definition>9954532 - Disclosure - Income Taxes (Components of Provision for Income Taxes) (Details)</link:definition>
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  <xs:element id="pbh_IncomeTaxReconciliationNondeductibleExpenseCompensationLimitations" abstract="false" name="IncomeTaxReconciliationNondeductibleExpenseCompensationLimitations" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="pbh_SupplyCommitmentTermOfAgreement" abstract="false" name="SupplyCommitmentTermOfAgreement" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="pbh_AmazonMember" abstract="true" name="AmazonMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="pbh_ShareRepurchaseProgramMember" abstract="true" name="ShareRepurchaseProgramMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="pbh_EffectiveIncomeTaxRateReconciliationUncertainTaxPositionPercentage" abstract="false" name="EffectiveIncomeTaxRateReconciliationUncertainTaxPositionPercentage" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="pbh_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsAllowanceForDoubtfulAccountsAndSalesReturns" abstract="false" name="DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsAllowanceForDoubtfulAccountsAndSalesReturns" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="pbh_PercentageofDepositsHeldinOneLocation" abstract="false" name="PercentageofDepositsHeldinOneLocation" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="pbh_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsIncrementalPerformanceShares" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsIncrementalPerformanceShares" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="pbh_DebtInstrumentReferenceRateFloor" abstract="false" name="DebtInstrumentReferenceRateFloor" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="pbh_IncreaseDecreaseInOperatingLeasesLiabilities" abstract="false" name="IncreaseDecreaseInOperatingLeasesLiabilities" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="pbh_CostOfSalesPolicyPolicyTextBlock" abstract="false" name="CostOfSalesPolicyPolicyTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="pbh_AdditionsToOperatingLeaseRightOfUseAssets" abstract="false" name="AdditionsToOperatingLeaseRightOfUseAssets" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="pbh_ContributionTrancheTwoMember" abstract="true" name="ContributionTrancheTwoMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="pbh_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesSaleAllowanceAndCashDiscountReserves" abstract="false" name="BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesSaleAllowanceAndCashDiscountReserves" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="pbh_RetirementPlanContributionAxis" abstract="true" name="RetirementPlanContributionAxis" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:dimensionItem" type="xbrli:stringItemType"/>
  <xs:element id="pbh_GoodwillandIntangibleAssetsbyGeographicAreasTableTextBlock" abstract="false" name="GoodwillandIntangibleAssetsbyGeographicAreasTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="pbh_LoansPayableTermB5AmendmentNo5Member" abstract="true" name="LoansPayableTermB5AmendmentNo5Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="pbh_OperatingAndFinanceLeaseLiabilityPaymentsDueYearThree" abstract="false" name="OperatingAndFinanceLeaseLiabilityPaymentsDueYearThree" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="pbh_EyeAndEarCareMember" abstract="true" name="EyeAndEarCareMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="pbh_DefinedBenefitPlanPlanAssetsPaymentForSettlementLumpSum" abstract="false" name="DefinedBenefitPlanPlanAssetsPaymentForSettlementLumpSum" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="pbh_WalmartMember" abstract="true" name="WalmartMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="pbh_DeferredTaxAssetsInventoryRecapitalization" abstract="false" name="DeferredTaxAssetsInventoryRecapitalization" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="pbh_CostOfSalesExclusiveOfDepreciation" abstract="false" name="CostOfSalesExclusiveOfDepreciation" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="pbh_ManufacturingFacilityLynchburgVirginiaMember" abstract="true" name="ManufacturingFacilityLynchburgVirginiaMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="pbh_CashDiscountsMember" abstract="true" name="CashDiscountsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="pbh_RetirementPlanContributionDomain" abstract="true" name="RetirementPlanContributionDomain" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="pbh_DermatologicalsMember" abstract="true" name="DermatologicalsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="pbh_WeightedAverageRemainingLeaseTermAbstract" abstract="true" name="WeightedAverageRemainingLeaseTermAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="pbh_LongTermIncentivePlan2020Member" abstract="true" name="LongTermIncentivePlan2020Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="pbh_RestrictedStockUnitsConversionRatioForSecuritiesIntoWhichEachRSUMayBeConverted" abstract="false" name="RestrictedStockUnitsConversionRatioForSecuritiesIntoWhichEachRSUMayBeConverted" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="pbh_ManufacturersMember" abstract="true" name="ManufacturersMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="pbh_OperatingAndFinanceLeaseLiabilityUndiscountedExcessAmount" abstract="false" name="OperatingAndFinanceLeaseLiabilityUndiscountedExcessAmount" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="pbh_AblRevolver2012Member" abstract="true" name="AblRevolver2012Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="pbh_SECSchedule1209ValuationAllowancesandReservesOther" abstract="false" name="SECSchedule1209ValuationAllowancesandReservesOther" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="pbh_ShareBasedCompensationArrangementByShareBasedPaymentAwardVestedInPeriodTotalFairValue" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardVestedInPeriodTotalFairValue" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="pbh_DeferredTaxAssetResearchAndDevelopment" abstract="false" name="DeferredTaxAssetResearchAndDevelopment" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="pbh_ScheduleofGoodwillandIntangibleAssetsbyGeographicAreasTable" abstract="true" name="ScheduleofGoodwillandIntangibleAssetsbyGeographicAreasTable" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType"/>
  <xs:element id="pbh_EffectiveIncomeTaxRateReconciliationNondeductibleExpenseCompensationLimitations" abstract="false" name="EffectiveIncomeTaxRateReconciliationNondeductibleExpenseCompensationLimitations" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="pbh_AkornOperatingCompanyLLCMember" abstract="true" name="AkornOperatingCompanyLLCMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="pbh_ThirdPartyManufacturingMember" abstract="true" name="ThirdPartyManufacturingMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="pbh_OperatingAndFinanceLeaseLiabilityPaymentDueAbstract" abstract="true" name="OperatingAndFinanceLeaseLiabilityPaymentDueAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="pbh_GeneralAndAdministrativeAndDepreciationAndAmortizationExpense" abstract="false" name="GeneralAndAdministrativeAndDepreciationAndAmortizationExpense" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="pbh_Top5BrandsMember" abstract="true" name="Top5BrandsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="pbh_DefinedBenefitPlanNetPeriodicBenefitCostCreditInterestCostStatementOfIncomeOrComprehensiveIncomeExtensibleListNotDisclosedFlag" abstract="false" name="DefinedBenefitPlanNetPeriodicBenefitCostCreditInterestCostStatementOfIncomeOrComprehensiveIncomeExtensibleListNotDisclosedFlag" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="pbh_FiniteLivedTradenamesandCustomerRelationshipsMember" abstract="true" name="FiniteLivedTradenamesandCustomerRelationshipsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="pbh_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedAndIssued" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedAndIssued" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="pbh_WeightedAverageDiscountRateAbstract" abstract="true" name="WeightedAverageDiscountRateAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="pbh_ScheduleOfIntangibleAssetsTableTextBlock" abstract="false" name="ScheduleOfIntangibleAssetsTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="pbh_NumberOfThirdPartyManufacturers" abstract="false" name="NumberOfThirdPartyManufacturers" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="pbh_CommonStockCapitalSharesReservedForFutureIssuanceNewShares" abstract="false" name="CommonStockCapitalSharesReservedForFutureIssuanceNewShares" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="pbh_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingWeightedAverageExercisePrice" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingWeightedAverageExercisePrice" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types1:perShareItemType"/>
  <xs:element id="pbh_ImpairmentOfIntangibleAssetFiniteLivedStatementOfIncomeOrComprehensiveIncomeExtensibleEnumerationNotDisclosedFlag" abstract="false" name="ImpairmentOfIntangibleAssetFiniteLivedStatementOfIncomeOrComprehensiveIncomeExtensibleEnumerationNotDisclosedFlag" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="pbh_BusinessCombinationNonAmortizableIntangibleAssetsAllocatedAmount" abstract="false" name="BusinessCombinationNonAmortizableIntangibleAssetsAllocatedAmount" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="pbh_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedNumber" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedNumber" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
</xs:schema>
