<SEC-DOCUMENT>0001209191-14-066468.txt : 20141104
<SEC-HEADER>0001209191-14-066468.hdr.sgml : 20141104
<ACCEPTANCE-DATETIME>20141104212730
ACCESSION NUMBER:		0001209191-14-066468
CONFORMED SUBMISSION TYPE:	3
PUBLIC DOCUMENT COUNT:		2
CONFORMED PERIOD OF REPORT:	20141104
FILED AS OF DATE:		20141104
DATE AS OF CHANGE:		20141104

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Xenon Pharmaceuticals Inc.
		CENTRAL INDEX KEY:			0001582313
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				980661854
		STATE OF INCORPORATION:			A1
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		200 - 3650 GILMORE WAY
		CITY:			BURNABY
		STATE:			A1
		ZIP:			V5G 48W
		BUSINESS PHONE:		(604) 484-3300

	MAIL ADDRESS:	
		STREET 1:		200 - 3650 GILMORE WAY
		CITY:			BURNABY
		STATE:			A1
		ZIP:			V5G 48W

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			ROBIN SHERRINGTON
		CENTRAL INDEX KEY:			0001619962

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-36687
		FILM NUMBER:		141194862

	MAIL ADDRESS:	
		STREET 1:		C/O XENON PHARMACEUTICALS INC.
		STREET 2:		200 - 3650 GILMORE WAY
		CITY:			BURNABY
		STATE:			A1
		ZIP:			V5G4W8
</SEC-HEADER>
<DOCUMENT>
<TYPE>3
<SEQUENCE>1
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<DESCRIPTION>FORM 3 SUBMISSION
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    <periodOfReport>2014-11-04</periodOfReport>

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    <issuer>
        <issuerCik>0001582313</issuerCik>
        <issuerName>Xenon Pharmaceuticals Inc.</issuerName>
        <issuerTradingSymbol>XENE</issuerTradingSymbol>
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            <rptOwnerName>ROBIN SHERRINGTON</rptOwnerName>
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            <rptOwnerStreet1>C/O XENON PHARMACEUTICALS INC.</rptOwnerStreet1>
            <rptOwnerStreet2>200 - 3650 GILMORE WAY</rptOwnerStreet2>
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            <rptOwnerState>A1</rptOwnerState>
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            <rptOwnerStateDescription>BRITISH COLUMBIA, CANADA</rptOwnerStateDescription>
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            <isDirector>0</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
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            <officerTitle>See Remarks</officerTitle>
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            <underlyingSecurity>
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                <underlyingSecurityShares>
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    <footnotes>
        <footnote id="F1">Reflects a 1-for-4.86 reverse stock split of the Issuer's outstanding shares effected October 1, 2014 (the &quot;Reverse Stock Split&quot;).</footnote>
        <footnote id="F2">The shares subject to the option fully vested on October 1, 2008.</footnote>
        <footnote id="F3">The shares subject to this option were due to expire on September 30, 2014. Pursuant to the Issuer's Amended and Restated Stock Option Plan, the expiration date of this option has been extended until five business days following the expiration of the Lock-up Agreement entered into in connection with the Issuer's initial public offering. The Lock-up Agreement will expire 180 days after the date of the final prospectus related to the initial public offering, or March 31, 2015.</footnote>
        <footnote id="F4">The exercise price was converted from $6.07 CAD using the closing rate of exchange of the Bank of Canada on the date of grant, after giving effect to the Reverse Stock Split. The actual exercise price is the Canadian dollar amount regardless of the exchange rate on the date of exercise.</footnote>
        <footnote id="F5">The shares subject to the option fully vested on January 1, 2009.</footnote>
        <footnote id="F6">The shares subject to the option fully vested on January 1, 2010.</footnote>
        <footnote id="F7">The shares subject to the option fully vested on January 1, 2011.</footnote>
        <footnote id="F8">The exercise price was converted from $3.74 CAD using the closing rate of exchange of the Bank of Canada on the date of grant, after giving effect to the Reverse Stock Split. The actual exercise price is the Canadian dollar amount regardless of the exchange rate on the date of exercise.</footnote>
        <footnote id="F9">The shares subject to the option fully vested on January 1, 2012.</footnote>
        <footnote id="F10">The shares subject to the option fully vested on January 1, 2013.</footnote>
        <footnote id="F11">The shares subject to the option fully vested on January 1, 2014.</footnote>
        <footnote id="F12">25% of the shares subject to the Option vested on the one year anniversary of January 1, 2011 (the &quot;January 2011 Vesting Commencement Date&quot;) and thereafter 1/48th of the shares subject to the Option vest on each monthly anniversary of the January 2011 Vesting Commencement Date.</footnote>
        <footnote id="F13">1/3 of the shares subject to the Option vested on March 12, 2011 (the &quot;March 2011 Vesting Commencement Date&quot;) and thereafter the remaining 2/3 of the shares subject to the Option vest each monthly anniversary of the March 2011 Vesting Commencement Date over the following 4 years.</footnote>
        <footnote id="F14">1/3 of the shares subject to the Option vested on January 1, 2012 (the &quot;First 2012 Vesting Commencement Date&quot;) and thereafter the remaining 2/3 of the shares subject to the Option vest each monthly anniversary of the First 2012 Vesting Commencement Date over the following 4 years.</footnote>
        <footnote id="F15">25% of the shares subject to the Option vested on the one year anniversary of January 1, 2012 (the &quot;Second 2012 Vesting Commencement Date&quot;) and thereafter 1/48th of the shares subject to the Option vest on each monthly anniversary of the Second 2012 Vesting Commencement Date.</footnote>
        <footnote id="F16">25% of the shares subject to the Option vested on the one year anniversary of January 1, 2013 (the &quot;First 2013 Vesting Commencement Date&quot;) and thereafter 1/48th of the shares subject to the Option vest on each monthly anniversary of the First 2013 Vesting Commencement Date.</footnote>
        <footnote id="F17">The exercise price was converted from $2.67 CAD using the closing rate of exchange of the Bank of Canada on the date of grant, after giving effect to the Reverse Stock Split. The actual exercise price is the Canadian dollar amount regardless of the exchange rate on the date of exercise.</footnote>
        <footnote id="F18">1/3 of the shares subject to the Option vested on January 1, 2013 (the &quot;Second 2013 Vesting Commencement Date&quot;) and thereafter the remaining 2/3 of the shares subject to the Option vest each monthly anniversary of the Second 2013 Vesting Commencement Date over the following 4 years.</footnote>
        <footnote id="F19">1/3 of the shares subject to the Option vested on January 14, 2014 (the &quot;First 2014 Vesting Commencement Date&quot;) and thereafter the remaining 2/3 of the shares subject to the Option vest each monthly anniversary of the First 2014 Vesting Commencement Date over the following 4 years.</footnote>
        <footnote id="F20">The exercise price was converted from $10.78 CAD using the closing rate of exchange of the Bank of Canada on the date of grant, after giving effect to the Reverse Stock Split. The actual exercise price is the Canadian dollar amount regardless of the exchange rate on the date of exercise.</footnote>
        <footnote id="F21">25% of the shares subject to the Option vested on the one year anniversary of January 1, 2014 (the &quot;Second 2014 Vesting Commencement Date&quot;) and thereafter 1/48th of the shares subject to the Option vest on each monthly anniversary of the Second 2014 Vesting Commencement Date.</footnote>
        <footnote id="F22">The shares subject to this option were due to expire on January 10, 2014. Pursuant to the Issuer's Amended and Restated Stock Option Plan, the expiration date of this option has been extended until five business days following the expiration of the Lock-up Agreement entered into in connection with the Issuer's initial public offering. The Lock-up Agreement will expire 180 days after the date of the final prospectus related to the initial public offering, or March 31, 2015.</footnote>
    </footnotes>

    <remarks>SVP, Business &amp; Corp Development</remarks>

    <ownerSignature>
        <signatureName>/s/ Barbara Mery, Attorney-in-fact for Robin Sherrington</signatureName>
        <signatureDate>2014-11-04</signatureDate>
    </ownerSignature>
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<PRE>
                                POWER OF ATTORNEY

        The undersigned, as a Section 16 reporting person of Xenon
Pharmaceuticals Inc. (the "Company"), hereby constitutes and appoints Wilson
Sonsini Goodrich & Rosati, P.C., the undersigned's true and lawful
attorney-in-fact to:

        1.  complete and execute Forms ID, 3,4 and 5 and other forms and all
            amendments thereto as such attorney-in-fact shall in his or her
            discretion determine to be required or advisable pursuant to Section
            16 of the Securities Exchange Act of 1934 (as amended) and the rules
            and regulations promulgated thereunder, or any successor laws and
            regulations, as a consequence of the undersigned's ownership,
            acquisition or disposition of securities of the Company; and

        2.  do all acts necessary in order to file such forms with the
            Securities and Exchange Commission, any securities exchange or
            national association, the Company and such other person or agency as
            the attorney-in-fact shall deem appropriate.

        The undersigned hereby ratifies and confirms all that said
attorneys-in-fact and agents shall do or cause to be done by virtue hereof. The
undersigned acknowledges that the foregoing attorneys-in-fact, in serving in
such capacity at the request of the undersigned, are not assuming, nor is the
Company assuming, any of the undersigned's responsibilities to comply with
Section 16 of the Securities Exchange Act of 1934 (as amended).

        This Power of Attorney shall remain in full force and effect until the
undersigned is no longer required to file Forms ID, 3, 4 and 5 with respect to
the undersigned's holdings of and transactions in securities issued by the
Company, unless earlier revoked by the undersigned in a signed writing delivered
to the Company and the foregoing attorneys-in-fact.

        IN WITNESS WHEREOF, the undersigned has caused this Power of Attorney to
be executed as of this 17th day of September, 2014.

                                        Signature:    /s/ Robin Sherrington
                                                    ----------------------------
                                                    Robin Sherrington
</PRE>
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