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Segment Disclosure (Tables) | 6 Months Ended
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Jun. 30, 2026
Segment Reporting [Abstract] |
Summary of Net Loss Related To Segment Expenses | The following table presents information about reported segment revenues, significant segment expenses, and segment loss:
|  | Three Months Ended June 30, |  |  | Six Months Ended June 30, |
|  | 2026 |  |  | 2025 |  |  | 2026 |  |  | 2025 |
Collaboration revenue |  | $ | — |  |  | $ | — |  |  | $ | — |  |  | $ | 7,500 |
Less: |  |  |  |  |  |  |  |  |  |  |  |
Direct external research and development costs: |  |  |  |  |  |  |  |  |  |  |  |
Azetukalner |  |  | 55,760 |  |  |  | 43,405 |  |  |  | 102,833 |  |  |  | 74,906 |
Pain programs |  |  | 5,582 |  |  |  | 925 |  |  |  | 9,973 |  |  |  | 1,977 |
Pre-clinical, discovery and other programs |  |  | 4,683 |  |  |  | 5,186 |  |  |  | 7,641 |  |  |  | 9,101 |
Personnel-related expenses |  |  | 27,731 |  |  |  | 22,386 |  |  |  | 56,741 |  |  |  | 45,026 |
Stock-based compensation expense |  |  | 16,732 |  |  |  | 13,713 |  |  |  | 33,626 |  |  |  | 25,887 |
Other research and development costs |  |  | 4,642 |  |  |  | 2,600 |  |  |  | 8,843 |  |  |  | 6,025 |
Other general and administrative costs |  |  | 8,025 |  |  |  | 6,014 |  |  |  | 15,826 |  |  |  | 11,545 |
Interest income |  |  | (12,145 | ) |  |  | (7,199 | ) |  |  | (19,052 | ) |  |  | (15,282 | )
Other segment items(1) |  |  | (274 | ) |  |  | (2,324 | ) |  |  | (3,393 | ) |  |  | (1,932 | )
Net loss |  | $ | (110,736 | ) |  | $ | (84,706 | ) |  | $ | (213,038 | ) |  | $ | (149,753 | )
(1) Other segment items include foreign exchange gain (loss) and income tax recovery.

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- Definition Tabular disclosure of segment reporting. Includes, but is not limited to, reconciliation of reportable segment amount to corresponding consolidated total. + References Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef -Topic 280 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 31 -Publisher FASB -URI https://asc.fasb.org/1943274/2147482810/280-10-50-31 Reference 2: http://www.xbrl.org/2009/role/commonPracticeRef -Topic 280 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 34 -Publisher FASB -URI https://asc.fasb.org/1943274/2147482810/280-10-50-34 Reference 3: http://www.xbrl.org/2009/role/commonPracticeRef -Topic 280 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 32 -Publisher FASB -URI https://asc.fasb.org/1943274/2147482810/280-10-50-32 Reference 4: http://www.xbrl.org/2009/role/commonPracticeRef -Topic 280 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 30 -Publisher FASB -URI https://asc.fasb.org/1943274/2147482810/280-10-50-30 Reference 5: http://www.xbrl.org/2009/role/commonPracticeRef -Topic 280 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 26C -Publisher FASB -URI https://asc.fasb.org/1943274/2147482810/280-10-50-26C Reference 6: http://www.xbrl.org/2009/role/commonPracticeRef -Topic 280 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 26B -Publisher FASB -URI https://asc.fasb.org/1943274/2147482810/280-10-50-26B Reference 7: http://www.xbrl.org/2009/role/commonPracticeRef -Topic 280 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 26A -Publisher FASB -URI https://asc.fasb.org/1943274/2147482810/280-10-50-26A Reference 8: http://www.xbrl.org/2009/role/commonPracticeRef -Topic 280 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 25 -Publisher FASB -URI https://asc.fasb.org/1943274/2147482810/280-10-50-25 Reference 9: http://www.xbrl.org/2009/role/commonPracticeRef -Topic 280 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 22 -Publisher FASB -URI https://asc.fasb.org/1943274/2147482810/280-10-50-22 Reference 10: http://www.xbrl.org/2009/role/commonPracticeRef -Topic 280 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 15 -Publisher FASB -URI https://asc.fasb.org/1943274/2147482810/280-10-50-15 + Details
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