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Segment Disclosure | 6 Months Ended
--- | ---
Jun. 30, 2026
Segment Reporting [Abstract] |
Segment Disclosure | 12. Segment disclosure: The Company operates as a single reportable segment dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. The Company has no products approved for sale and has not generated any revenue from product sales. The Company’s Chief Executive Officer acts as the chief operating decision maker and manages the Company’s operations on a consolidated basis, using net loss to assess performance and allocate resources. The accounting policies for the operating segment are consistent with the Company's policies for the consolidated financial statements. The measure of segment assets is reported on the condensed consolidated balance sheet as total consolidated assets, with a majority of these assets located in the United States. The following table presents information about reported segment revenues, significant segment expenses, and segment loss:
|  | Three Months Ended June 30, |  |  | Six Months Ended June 30, |
|  | 2026 |  |  | 2025 |  |  | 2026 |  |  | 2025 |
Collaboration revenue |  | $ | — |  |  | $ | — |  |  | $ | — |  |  | $ | 7,500 |
Less: |  |  |  |  |  |  |  |  |  |  |  |
Direct external research and development costs: |  |  |  |  |  |  |  |  |  |  |  |
Azetukalner |  |  | 55,760 |  |  |  | 43,405 |  |  |  | 102,833 |  |  |  | 74,906 |
Pain programs |  |  | 5,582 |  |  |  | 925 |  |  |  | 9,973 |  |  |  | 1,977 |
Pre-clinical, discovery and other programs |  |  | 4,683 |  |  |  | 5,186 |  |  |  | 7,641 |  |  |  | 9,101 |
Personnel-related expenses |  |  | 27,731 |  |  |  | 22,386 |  |  |  | 56,741 |  |  |  | 45,026 |
Stock-based compensation expense |  |  | 16,732 |  |  |  | 13,713 |  |  |  | 33,626 |  |  |  | 25,887 |
Other research and development costs |  |  | 4,642 |  |  |  | 2,600 |  |  |  | 8,843 |  |  |  | 6,025 |
Other general and administrative costs |  |  | 8,025 |  |  |  | 6,014 |  |  |  | 15,826 |  |  |  | 11,545 |
Interest income |  |  | (12,145 | ) |  |  | (7,199 | ) |  |  | (19,052 | ) |  |  | (15,282 | )
Other segment items(1) |  |  | (274 | ) |  |  | (2,324 | ) |  |  | (3,393 | ) |  |  | (1,932 | )
Net loss |  | $ | (110,736 | ) |  | $ | (84,706 | ) |  | $ | (213,038 | ) |  | $ | (149,753 | )
(1) Other segment items include foreign exchange gain (loss) and income tax recovery.

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