<SEC-DOCUMENT>0001213900-25-075188.txt : 20250812
<SEC-HEADER>0001213900-25-075188.hdr.sgml : 20250812
<ACCEPTANCE-DATETIME>20250812205220
ACCESSION NUMBER:		0001213900-25-075188
CONFORMED SUBMISSION TYPE:	SCHEDULE 13G/A
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20250812
DATE AS OF CHANGE:		20250812

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			SOLENO THERAPEUTICS INC
		CENTRAL INDEX KEY:			0001484565
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		EIN:				770523891
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SCHEDULE 13G/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-88637
		FILM NUMBER:		251208609

	BUSINESS ADDRESS:	
		STREET 1:		100 MARINE PARKWAY, SUITE 400
		CITY:			REDWOOD CITY
		STATE:			CA
		ZIP:			94065
		BUSINESS PHONE:		650-213-8444

	MAIL ADDRESS:	
		STREET 1:		100 MARINE PARKWAY, SUITE 400
		CITY:			REDWOOD CITY
		STATE:			CA
		ZIP:			94065

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Capnia, Inc.
		DATE OF NAME CHANGE:	20100219

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Vivo Opportunity Fund Holdings, L.P.
		CENTRAL INDEX KEY:			0001930214
		ORGANIZATION NAME:           	
		EIN:				873802421
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SCHEDULE 13G/A

	BUSINESS ADDRESS:	
		STREET 1:		192 LYTTON AVENUE
		CITY:			PALO ALTO
		STATE:			CA
		ZIP:			94301
		BUSINESS PHONE:		6506880818

	MAIL ADDRESS:	
		STREET 1:		192 LYTTON AVENUE
		CITY:			PALO ALTO
		STATE:			CA
		ZIP:			94301
</SEC-HEADER>
<DOCUMENT>
<TYPE>SCHEDULE 13G/A
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
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<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/schedule13g" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>SCHEDULE 13G/A</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <!-- Field: Pseudo-Tag; ID: Name; Data: Vivo Opportunity Fund Holdings, L.P. -->
          <cik>0001930214</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>


    </filerInfo>
  </headerData>
  <formData>
    <coverPageHeader>
      <amendmentNo>2</amendmentNo>
      <securitiesClassTitle>Common Stock, $0.001 par value per share</securitiesClassTitle>
      <eventDateRequiresFilingThisStatement>06/30/2025</eventDateRequiresFilingThisStatement>
      <issuerInfo>
        <issuerCik>0001484565</issuerCik>
        <issuerName>Soleno Therapeutics, Inc.</issuerName>
        <issuerCusip>834203309</issuerCusip>
        <issuerPrincipalExecutiveOfficeAddress>
          <com:street1>100 Marine Parkway</com:street1>
          <com:street2>Suite 400</com:street2>
          <com:city>Redwood City</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>94065</com:zipCode>
        </issuerPrincipalExecutiveOfficeAddress>
      </issuerInfo>
      <designateRulesPursuantThisScheduleFiled>
        <designateRulePursuantThisScheduleFiled>Rule 13d-1(c)</designateRulePursuantThisScheduleFiled>
      </designateRulesPursuantThisScheduleFiled>
    </coverPageHeader>
    <coverPageHeaderReportingPersonDetails>


      <reportingPersonName>Vivo Opportunity Fund Holdings, L.P.</reportingPersonName>
      <memberGroup>b</memberGroup>
      <citizenshipOrOrganization>DE</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>3958294.00</soleVotingPower>
        <sharedVotingPower>0.00</sharedVotingPower>
        <soleDispositivePower>3958294.00</soleDispositivePower>
        <sharedDispositivePower>0.00</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>3958294.00</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
      <classPercent>7.4</classPercent>
      <typeOfReportingPerson>PN</typeOfReportingPerson>
      <comments>The shares of common stock, $0.001 par value (the "Common Stock") of Soleno Therapeutics, Inc. (the "Issuer") are held of record by Vivo Opportunity Fund Holdings, L.P. Vivo Opportunity, LLC is the general partner of Vivo Opportunity Fund Holdings, L.P.

The percent of class was calculated based upon 53,145,009 shares of Common Stock of the Issuer outstanding as of August 1, 2025, as reported in the Issuer's Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission ("SEC") on August 6, 2025.</comments>
    </coverPageHeaderReportingPersonDetails>
    <coverPageHeaderReportingPersonDetails>


      <reportingPersonName>Vivo Opportunity, LLC</reportingPersonName>
      <memberGroup>b</memberGroup>
      <citizenshipOrOrganization>DE</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>3958294.00</soleVotingPower>
        <sharedVotingPower>0.00</sharedVotingPower>
        <soleDispositivePower>3958294.00</soleDispositivePower>
        <sharedDispositivePower>0.00</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>3958294.00</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
      <classPercent>7.4</classPercent>
      <typeOfReportingPerson>OO</typeOfReportingPerson>
      <comments>The shares of Common Stock of the Issuer are held of record by Vivo Opportunity Fund Holdings, L.P. Vivo Opportunity, LLC is the general partner of Vivo Opportunity Fund Holdings, L.P.

The percent of class was calculated based upon 53,145,009 shares of Common Stock of the Issuer outstanding as of August 1, 2025, as reported in the Issuer's Quarterly Report on Form 10-Q filed with the SEC on August 6, 2025.</comments>
    </coverPageHeaderReportingPersonDetails>
    <items>
      <item1>
        <issuerName>Soleno Therapeutics, Inc.</issuerName>
        <issuerPrincipalExecutiveOfficeAddress>100 Marine Parkway, Suite 400, Redwood City, CA 94065</issuerPrincipalExecutiveOfficeAddress>
      </item1>
      <item2>
        <filingPersonName>(i) Vivo Opportunity Fund Holdings, L.P., a Delaware limited partnership; and

(ii) Vivo Opportunity, LLC, a Delaware limited liability company. Vivo Opportunity, LLC is the general partner of Vivo Opportunity Fund Holdings, L.P.</filingPersonName>
        <principalBusinessOfficeOrResidenceAddress>The address of the principal business office of the Reporting Persons is 192 Lytton Avenue, Palo Alto, CA 94301.</principalBusinessOfficeOrResidenceAddress>
        <citizenship>(i) Vivo Opportunity Fund Holdings, L.P., a Delaware limited partnership; and

(ii) Vivo Opportunity, LLC, a Delaware limited liability company. Vivo Opportunity, LLC is the general partner of Vivo Opportunity Fund Holdings, L.P.</citizenship>
      </item2>
      <item3>
        <notApplicableFlag>Y</notApplicableFlag>
      </item3>
      <item4>
        <amountBeneficiallyOwned>The information set forth in rows 5 through 11 of the cover pages is incorporated by reference into this Item 4.</amountBeneficiallyOwned>
        <classPercent>The information set forth in rows 5 through 11 of the cover pages is incorporated by reference into this Item 4.

Vivo Opportunity Fund Holdings, L.P. - 7.4%*
Vivo Opportunity, LLC - 7.4%*

* The percent of class was calculated based upon 53,145,009 shares of Common Stock of the Issuer outstanding as of August 1, 2025, as reported in the Issuer's Quarterly Report on Form 10-Q filed with the SEC on August 6, 2025.</classPercent>
        <numberOfSharesPersonHas>
          <solePowerOrDirectToVote>Vivo Opportunity Fund Holdings, L.P. - 3,958,294
Vivo Opportunity, LLC -3,958,294</solePowerOrDirectToVote>
          <sharedPowerOrDirectToVote>Vivo Opportunity Fund Holdings, L.P.- 0
Vivo Opportunity, LLC - 0</sharedPowerOrDirectToVote>
          <solePowerOrDirectToDispose>Vivo Opportunity Fund Holdings, L.P. - 3,958,2944
Vivo Opportunity, LLC - 3,958,294</solePowerOrDirectToDispose>
          <sharedPowerOrDirectToDispose>Vivo Opportunity Fund Holdings, L.P. - 0
Vivo Opportunity, LLC - 0</sharedPowerOrDirectToDispose>
        </numberOfSharesPersonHas>
      </item4>
      <item5>
        <notApplicableFlag>Y</notApplicableFlag>
      </item5>
      <item6>
        <notApplicableFlag>Y</notApplicableFlag>
      </item6>
      <item7>
        <notApplicableFlag>Y</notApplicableFlag>
      </item7>
      <item8>
        <notApplicableFlag>Y</notApplicableFlag>
      </item8>
      <item9>
        <notApplicableFlag>Y</notApplicableFlag>
      </item9>
      <item10>
        <notApplicableFlag>N</notApplicableFlag>
        <certifications>By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11.</certifications>
      </item10>
    </items>
    <signatureInformation>
      <reportingPersonName>Vivo Opportunity Fund Holdings, L.P.</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Kevin Dai</signature>
        <title>Kevin Dai/Managing Member</title>
        <date>08/12/2025</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>Vivo Opportunity, LLC</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Kevin Dai</signature>
        <title>Kevin Dai/Managing Member</title>
        <date>08/12/2025</date>
      </signatureDetails>
    </signatureInformation>
  </formData>
</edgarSubmission>
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</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
