<SEC-DOCUMENT>0001415889-25-009079.txt : 20250327
<SEC-HEADER>0001415889-25-009079.hdr.sgml : 20250327
<ACCEPTANCE-DATETIME>20250327085551
ACCESSION NUMBER:		0001415889-25-009079
CONFORMED SUBMISSION TYPE:	144
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20250327
DATE AS OF CHANGE:		20250327

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			SOLENO THERAPEUTICS INC
		CENTRAL INDEX KEY:			0001484565
		STANDARD INDUSTRIAL CLASSIFICATION:	ELECTROMEDICAL & ELECTROTHERAPEUTIC APPARATUS [3845]
		ORGANIZATION NAME:           	08 Industrial Applications and Services
		EIN:				770523891
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		144
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	001-36593
		FILM NUMBER:		25775534

	BUSINESS ADDRESS:	
		STREET 1:		100 MARINE PARKWAY, SUITE 400
		CITY:			REDWOOD CITY
		STATE:			CA
		ZIP:			94065
		BUSINESS PHONE:		650-213-8444

	MAIL ADDRESS:	
		STREET 1:		100 MARINE PARKWAY, SUITE 400
		CITY:			REDWOOD CITY
		STATE:			CA
		ZIP:			94065

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Capnia, Inc.
		DATE OF NAME CHANGE:	20100219

REPORTING-OWNER:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Mackaness James H
		CENTRAL INDEX KEY:			0001422484
		ORGANIZATION NAME:           	

	FILING VALUES:
		FORM TYPE:		144

	MAIL ADDRESS:	
		STREET 1:		1212 TERRA BELLA AVENUE
		CITY:			MOUNTAIN VIEW
		STATE:			CA
		ZIP:			94043
</SEC-HEADER>
<DOCUMENT>
<TYPE>144
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
	<headerData>
        <submissionType>144</submissionType>
                <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001422484</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
        <liveTestFlag>LIVE</liveTestFlag>




                </filerInfo>
    </headerData>

     <formData>
        <issuerInfo>
            <issuerCik>0001484565</issuerCik>
			<issuerName>SOLENO THERAPEUTICS INC</issuerName>


			    <secFileNumber>001-36593</secFileNumber>


			<issuerAddress>
				<com:street1>100 MARINE PARKWAY, SUITE 400</com:street1>
                				<com:city>REDWOOD CITY</com:city>
				<com:stateOrCountry>CA</com:stateOrCountry>
				<com:zipCode>94065</com:zipCode>
			</issuerAddress>

			<issuerContactPhone>650-213-8444</issuerContactPhone>
			<nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>James H Mackaness</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>

			<relationshipsToIssuer>

				    <relationshipToIssuer>Officer</relationshipToIssuer>

			</relationshipsToIssuer>
		</issuerInfo>

				          <securitiesInformation>
			<securitiesClassTitle>Common Stock</securitiesClassTitle>
			<brokerOrMarketmakerDetails>
				<name>ETrade Financial Corporation</name>
				<address>
				<com:street1>P.O. Box 484</com:street1>
                				<com:city>Jersey City</com:city>
				<com:stateOrCountry>NJ</com:stateOrCountry>
				<com:zipCode>07303</com:zipCode>
				</address>
			</brokerOrMarketmakerDetails>
			<noOfUnitsSold>92500</noOfUnitsSold>
			<aggregateMarketValue>4629625.00</aggregateMarketValue>
			<noOfUnitsOutstanding>45857291</noOfUnitsOutstanding>
			<approxSaleDate>03/27/2025</approxSaleDate>
			<securitiesExchangeName>NASDAQ</securitiesExchangeName>
		</securitiesInformation>

    		       <securitiesToBeSold>
         <securitiesClassTitle>Common Stock</securitiesClassTitle>
         <acquiredDate>03/26/2025</acquiredDate>
         <natureOfAcquisitionTransaction>Vesting of Restricted Stock Units - See Remarks</natureOfAcquisitionTransaction>
                  <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
                  <isGiftTransaction>N</isGiftTransaction>
		          <amountOfSecuritiesAcquired>22500</amountOfSecuritiesAcquired>
                  <paymentDate>03/26/2025</paymentDate>
                  <natureOfPayment>Equity Compensation</natureOfPayment>
      </securitiesToBeSold>
             <securitiesToBeSold>
         <securitiesClassTitle>Common Stock</securitiesClassTitle>
         <acquiredDate>03/27/2025</acquiredDate>
         <natureOfAcquisitionTransaction>Stock option exercises</natureOfAcquisitionTransaction>
                  <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
                  <isGiftTransaction>N</isGiftTransaction>
		          <amountOfSecuritiesAcquired>70000</amountOfSecuritiesAcquired>
                  <paymentDate>03/27/2025</paymentDate>
                  <natureOfPayment>Cash</natureOfPayment>
      </securitiesToBeSold>

    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>


     <securitiesSoldInPast3Months>
         <sellerDetails>
            <name>James Mackaness</name>
            <address>
               <com:street1>c/o Soleno Therapeutics, Inc.</com:street1>
                              <com:street2>100 Marine Pkwy, Suite 400</com:street2>
                              <com:city>Redwood City</com:city>
               <com:stateOrCountry>CA</com:stateOrCountry>
               <com:zipCode>94065</com:zipCode>
            </address>
         </sellerDetails>
         <securitiesClassTitle>Common Stock</securitiesClassTitle>
         <saleDate>01/02/2025</saleDate>
         <amountOfSecuritiesSold>4083</amountOfSecuritiesSold>
         <grossProceeds>185405.71</grossProceeds>
      </securitiesSoldInPast3Months>

     <securitiesSoldInPast3Months>
         <sellerDetails>
            <name>James Mackaness</name>
            <address>
               <com:street1>c/o Soleno Therapeutics, Inc.</com:street1>
                              <com:street2>100 Marine Pkwy, Suite 400</com:street2>
                              <com:city>Redwood City</com:city>
               <com:stateOrCountry>CA</com:stateOrCountry>
               <com:zipCode>94065</com:zipCode>
            </address>
         </sellerDetails>
         <securitiesClassTitle>Common Stock</securitiesClassTitle>
         <saleDate>01/03/2025</saleDate>
         <amountOfSecuritiesSold>3791</amountOfSecuritiesSold>
         <grossProceeds>175054.73</grossProceeds>
      </securitiesSoldInPast3Months>

    		<remarks>Approximately 22,500 shares to be sold to cover tax withholding obligations in connection with the vesting of restricted stock units.</remarks>

        <noticeSignature>
            <noticeDate>03/27/2025</noticeDate>
                        <signature> /s/ James H. Mackaness</signature>
        </noticeSignature>
	</formData>
    </edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
