EX-32.1 9 htfl-20251231xex32_1.htm EX-32.1

Exhibit 32.1

CERTIFICATION PURSUANT TO

18 U.S.C. SECTION 1350, AS ADOPTED PURSUANT TO

SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

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In connection with the Annual Report of Heartflow, Inc. (the “Company”) on Form 10-K for the year ended Dec ember 3 1, 2025 as filed with the Securities and Exchange Commission on the date hereof (the “Report”), I certify that, to the best of my knowledge, pursuant to 18 U.S.C. § 1350, as adopted pursuant to § 906 of the Sarbanes-Oxley Act of 2002, that:

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| 1. The Report fully complies with the requirements of section 13(a) or 15(d) of the Securities Exchange Act of 1934, as amended; and

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| 2. The information contained in the Report fairly presents, in all material respects, the financial condition and result s of operations of the Company.

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Date: March 18, 2026 | By: | /s/ John C.M. Farquhar
﻿ |  |  | John C.M. Farquhar
﻿ |  |  | President and Chief Executive Officer
﻿ |  |  | (Principal Executive Officer)

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