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Insider Trading Arrangements

3 Months Ended

Dec. 31, 2025

shares

Trading Arrangements, by Individual

Material Terms of Trading Arrangement

​

​	​	​	​	Trading Arrangement		​	​
Name	Title	Action	Effective Date	Rule 10b5-1	Non Rule 10b5-1	Scheduled Expiration Date of Trading Plan(1)	Maximum Shares Subject to Trading Plan
Sanj K. Patel	Chairman and CEO	Adoption	October 31, 2025	X	​	December 31, 2026	564,182
John Paolini	EVP, Chief Medical Officer	Adoption	November 18, 2025	X	​	November 19, 2026	98,424

​

(1) A trading arrangement may expire on an earlier date if all contemplated transactions are completed before such trading arrangement’s expiration date, upon termination by broker or the holder of the trading arrangement or as otherwise provided in the trading arrangement.

Sanj K. Patel

Trading Arrangements, by Individual

Name

Sanj K. Patel

Title

Chairman and CEO

Rule 10b5-1 Arrangement Adopted

true

Adoption Date

Oct. 31, 2025

Expiration Date

Dec. 31, 2026

Aggregate Available

564,182

John Paolini

Trading Arrangements, by Individual

Name

John Paolini

Title

EVP, Chief Medical Officer

Rule 10b5-1 Arrangement Adopted

true

Adoption Date

Nov. 18, 2025

Expiration Date

Nov. 19, 2026

Aggregate Available

98,424

X

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-Name Regulation S-K
-Number 229
-Section 408
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