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Condensed Consolidated Statements of Changes in Stockholder's Equity (Unaudited) - USD ($)
$ in Thousands
Total
Common Stock [Member]
Additional Paid-In Capital [Member]
Accumulated Other Comprehensive Income (Loss) [Member]
Accumulated Deficit [Member]
Beginning balance at Dec. 31, 2018 $ 160,972 $ 5 $ 437,856 $ (123) $ (276,766)
Beginning balance, Shares at Dec. 31, 2018   56,279      
Issuance of common stock in follow-on offering, net of offering costs 109,604 $ 1 109,603    
Issuance of common stock in follow-on offering, shares   6,900      
Issuance of common stock upon exercise of stock options 192   192    
Issuance of common stock upon exercise of stock options, shares   39      
Share-based compensation expense 4,559   4,559    
Net loss (50,574)       (50,574)
Foreign currency gain (loss) 2     2  
Ending balance at Mar. 31, 2019 224,755 $ 6 552,210 (121) (327,340)
Ending balance, Shares at Mar. 31, 2019   63,218      
Beginning balance at Dec. 31, 2019 34,229 $ 6 615,850 (154) (581,473)
Beginning balance, Shares at Dec. 31, 2019   63,938      
Issuance of common stock in follow-on offering, net of offering costs 381,458 $ 1 381,457    
Issuance of common stock in follow-on offering, shares   10,925      
Issuance of common stock upon exercise of stock options 1,674   1,674    
Issuance of common stock upon exercise of stock options, shares   559      
Share-based compensation expense 9,294   9,294    
Unrealized gain on available-for-sale investments 1,394     1,394  
Net loss (168,822)       (168,822)
Foreign currency gain (loss) (230)     (230)  
Ending balance at Mar. 31, 2020 $ 258,997 $ 7 $ 1,008,275 $ 1,010 $ (750,295)
Ending balance, Shares at Mar. 31, 2020   75,422