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Nature of Organization and Operations - Additional Information (Detail) $ / shares in Units, $ in Thousands |  |  |  |  |  | 9 Months Ended |  |  |
--- | --- | --- | --- | --- | --- | --- | --- | --- | ---
Nov. 02, 2020 USD ($) | Oct. 27, 2020 USD ($) | May 12, 2020 USD ($) | Jan. 13, 2020 USD ($) $ / shares shares | Sep. 16, 2019 USD ($) | Sep. 30, 2020 USD ($) | Sep. 30, 2019 USD ($) | May 06, 2020 CounterParty $ / shares | Dec. 31, 2019 USD ($) | Sep. 11, 2019 CounterParty $ / shares
Nature Of Organization And Operations [Line Items] |  |  |  |  |  |  |  |  |  |
Proceeds from follow-on public offering after deducting underwriting discounts and commissions |  |  |  |  |  | $ 381,423 | $ 109,629 |  |  |
Cash and cash equivalents |  |  |  |  |  | 415,560 | $ 433,995 |  | $ 351,985 |
Marketable securities |  |  |  |  |  | $ 312,598 |  |  |  |
Subsequent Event [Member] | Collaboration and License Agreement [Member] | Swedish Orphan Biovitrum AB (Publ) [Member] |  |  |  |  |  |  |  |  |  |
Nature Of Organization And Operations [Line Items] |  |  |  |  |  |  |  |  |  |
Upfront Payment | $ 250,000 | $ 250,000 |  |  |  |  |  |  |  |
Capped Call Transactions [Member] |  |  |  |  |  |  |  |  |  |
Nature Of Organization And Operations [Line Items] |  |  |  |  |  |  |  |  |  |
Number of counterparties | CounterParty |  |  |  |  |  |  |  | 2 |  | 2
Initial conversion price | $ / shares |  |  |  |  |  |  |  | $ 39.4625 |  | $ 39.4625
Follow-on Public Offerings [Member] |  |  |  |  |  |  |  |  |  |
Nature Of Organization And Operations [Line Items] |  |  |  |  |  |  |  |  |  |
Issuance of common stock in follow-on offering, shares | shares |  |  |  | 10,925,000 |  |  |  |  |  |
Price of common stock | $ / shares |  |  |  | $ 37.00 |  |  |  |  |  |
Proceeds from follow-on public offering after deducting underwriting discounts and commissions |  |  |  | $ 381,500 |  |  |  |  |  |
Underwriting discounts and commissions |  |  |  | 22,200 |  |  |  |  |  |
Offering Cost |  |  |  | $ 500 |  |  |  |  |  |
Over Allotment Option [Member] |  |  |  |  |  |  |  |  |  |
Nature Of Organization And Operations [Line Items] |  |  |  |  |  |  |  |  |  |
Issuance of common stock in follow-on offering, shares | shares |  |  |  | 1,425,000 |  |  |  |  |  |
Price of common stock | $ / shares |  |  |  | $ 37.00 |  |  |  |  |  |
Convertible Senior Notes Due 2026 [Member] |  |  |  |  |  |  |  |  |  |
Nature Of Organization And Operations [Line Items] |  |  |  |  |  |  |  |  |  |
Debt instrument, stated percentage |  |  | 3.50% |  |  |  |  |  |  |
Debt instrument, due and payment description |  |  |  |  |  | The 2020 Convertible Notes are senior unsecured obligations of the Company and bear interest at a rate of 3.5% per year payable semiannually in arrears on March 15 and September 15 of each year, beginning on March 15, 2020. |  |  |  |
Debt instrument, frequency of periodic payment |  |  |  |  |  | semiannually |  |  |  |
Maturity date |  |  | Sep. 15, 2026 |  |  |  |  |  |  |
Convertible Senior Notes Due 2026 [Member] | 2020 Convertible Notes [Member] |  |  |  |  |  |  |  |  |  |
Nature Of Organization And Operations [Line Items] |  |  |  |  |  |  |  |  |  |
Debt instrument, stated percentage |  |  | 3.50% |  |  |  |  |  |  |
Purchase price of convertible notes |  |  | $ 328,900 |  |  |  |  |  |  |
Net proceeds from the sale of the notes |  |  | 322,900 |  |  |  |  |  |  |
Payments of transactions cost |  |  | 43,100 |  |  |  |  |  |  |
Convertible Senior Notes Due 2026 [Member] | Private Offering [Member] | 2020 Convertible Notes [Member] |  |  |  |  |  |  |  |  |  |
Nature Of Organization And Operations [Line Items] |  |  |  |  |  |  |  |  |  |
Principal amount |  |  | 300,000 |  |  |  |  |  |  |
Convertible Senior Notes Due 2026 [Member] |  |  |  |  |  |  |  |  |  |
Nature Of Organization And Operations [Line Items] |  |  |  |  |  |  |  |  |  |
Principal amount |  |  |  |  |  | $ 353,800 |  |  |  |
Debt instrument, stated percentage |  |  |  |  | 3.50% |  |  |  |  |
Debt instrument, due and payment description |  |  |  |  |  | The Convertible Notes are senior unsecured obligations of the Company and bear interest at a rate of 3.5% per year payable semiannually in arrears on March 15 and September 15 of each year, beginning on March 15, 2020. |  |  |  |
Debt instrument, frequency of periodic payment |  |  |  |  |  | semiannually |  |  |  |
Maturity date |  |  |  |  | Sep. 15, 2026 |  |  |  |  |
Convertible Senior Notes Due 2026 [Member] | 2020 Convertible Notes [Member] |  |  |  |  |  |  |  |  |  |
Nature Of Organization And Operations [Line Items] |  |  |  |  |  |  |  |  |  |
Net proceeds from the sale of the notes |  |  | 322,900 |  |  |  |  |  |  |
Payments of transactions cost |  |  | 43,100 |  |  |  |  |  |  |
Convertible Senior Notes Due 2026 [Member] | 2019 Convertible Notes [Member] |  |  |  |  |  |  |  |  |  |
Nature Of Organization And Operations [Line Items] |  |  |  |  |  |  |  |  |  |
Debt instrument, stated percentage |  |  |  |  | 3.50% |  |  |  |  |
Net proceeds from the sale of the notes |  |  |  |  | $ 212,900 |  |  |  |  |
Payments of transactions cost |  |  |  |  | 28,400 |  |  |  |  |
Convertible Senior Notes Due 2026 [Member] | Private Offering [Member] | 2020 Convertible Notes [Member] |  |  |  |  |  |  |  |  |  |
Nature Of Organization And Operations [Line Items] |  |  |  |  |  |  |  |  |  |
Principal amount |  |  | $ 300,000 |  |  |  |  |  |  |
Convertible Senior Notes Due 2026 [Member] | Private Offering [Member] | 2019 Convertible Notes [Member] |  |  |  |  |  |  |  |  |  |
Nature Of Organization And Operations [Line Items] |  |  |  |  |  |  |  |  |  |
Principal amount |  |  |  |  | $ 220,000 |  |  |  |  |

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