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Condensed Consolidated Statements of Changes in Stockholder's Equity (Unaudited) - USD ($)
$ in Thousands
Total
Common Stock [Member]
Additional Paid-In Capital [Member]
Accumulated Other Comprehensive Income (Loss) [Member]
Accumulated Deficit [Member]
Beginning balance at Dec. 31, 2018 $ 160,972 $ 5 $ 437,856 $ (123) $ (276,766)
Beginning balance, Shares at Dec. 31, 2018   56,279      
Issuance of common stock in follow-on offering, net of offering costs 109,604 $ 1 109,603    
Issuance of common stock in follow-on offering, shares   6,900      
Issuance of common stock upon exercise of stock options 192   192    
Issuance of common stock upon exercise of stock options, shares   39      
Share-based compensation expense 4,559   4,559    
Net loss (50,574)       (50,574)
Foreign currency gain (loss) 2     2  
Ending balance at Mar. 31, 2019 224,755 $ 6 552,210 (121) (327,340)
Ending balance, Shares at Mar. 31, 2019   63,218      
Beginning balance at Dec. 31, 2018 160,972 $ 5 437,856 (123) (276,766)
Beginning balance, Shares at Dec. 31, 2018   56,279      
Net loss (191,489)        
Foreign currency gain (loss) (83)        
Ending balance at Sep. 30, 2019 139,562 $ 6 608,016 (205) (468,255)
Ending balance, Shares at Sep. 30, 2019   63,872      
Beginning balance at Mar. 31, 2019 224,755 $ 6 552,210 (121) (327,340)
Beginning balance, Shares at Mar. 31, 2019   63,218      
Deferred issuance costs (23)   (23)    
Issuance of common stock upon exercise of stock options 1,262   1,262    
Issuance of common stock upon exercise of stock options, shares   454      
Share-based compensation expense 4,183   4,183    
Net loss (71,090)       (71,090)
Foreign currency gain (loss) (1)     (1)  
Ending balance at Jun. 30, 2019 159,086 $ 6 557,632 (122) (398,430)
Ending balance, Shares at Jun. 30, 2019   63,672      
Issuance of common stock upon exercise of stock options 955   955    
Issuance of common stock upon exercise of stock options, shares   200      
Share-based compensation expense 5,295   5,295    
Recognition of debt discount on convertible notes 72,514   72,514    
Purchase of capped call transactions and associated costs (28,380)   (28,380)    
Net loss (69,825)       (69,825)
Foreign currency gain (loss) (83)     (83)  
Ending balance at Sep. 30, 2019 139,562 $ 6 608,016 (205) (468,255)
Ending balance, Shares at Sep. 30, 2019   63,872      
Beginning balance at Dec. 31, 2019 34,229 $ 6 615,850 (154) (581,473)
Beginning balance, Shares at Dec. 31, 2019   63,938      
Issuance of common stock in follow-on offering, net of offering costs 381,458 $ 1 381,457    
Issuance of common stock in follow-on offering, shares   10,925      
Issuance of common stock upon exercise of stock options 1,674   1,674    
Issuance of common stock upon exercise of stock options, shares   559      
Share-based compensation expense 9,294   9,294    
Unrealized gain (loss) on available-for-sale investments 1,394     1,394  
Net loss (168,822)       (168,822)
Foreign currency gain (loss) (230)     (230)  
Ending balance at Mar. 31, 2020 258,997 $ 7 1,008,275 1,010 (750,295)
Ending balance, Shares at Mar. 31, 2020   75,422      
Beginning balance at Dec. 31, 2019 34,229 $ 6 615,850 (154) (581,473)
Beginning balance, Shares at Dec. 31, 2019   63,938      
Unrealized gain (loss) on available-for-sale investments 122        
Net loss (423,139)        
Foreign currency gain (loss) (1,727)        
Ending balance at Sep. 30, 2020 105,840 $ 8 1,112,203 (1,759) (1,004,612)
Ending balance, Shares at Sep. 30, 2020   75,694      
Beginning balance at Mar. 31, 2020 258,997 $ 7 1,008,275 1,010 (750,295)
Beginning balance, Shares at Mar. 31, 2020   75,422      
Deferred issuance costs (35)   (35)    
Issuance of common stock upon exercise of stock options 1,355 $ 1 1,354    
Issuance of common stock upon exercise of stock options, shares   148      
Share-based compensation expense 11,489   11,489    
Unrealized gain (loss) on available-for-sale investments (842)     (842)  
Recognition of debt discount on convertible notes 122,147   122,147    
Purchase of capped call transactions and associated costs (43,112)   (43,112)    
Issuance of common stock to employee stock purchase plan 521   521    
Issuance of common stock to employee stock purchase plan, shares   20      
Net loss (118,617)       (118,617)
Foreign currency gain (loss) 161     161  
Ending balance at Jun. 30, 2020 232,064 $ 8 1,100,639 329 (868,912)
Ending balance, Shares at Jun. 30, 2020   75,590      
Issuance of common stock upon exercise of stock options 1,127   1,127    
Issuance of common stock upon exercise of stock options, shares   104      
Share-based compensation expense 12,099   12,099    
Unrealized gain (loss) on available-for-sale investments (430)     (430)  
Recognition of debt discount on convertible notes (1,662)   (1,662)    
Net loss (135,700)       (135,700)
Foreign currency gain (loss) (1,658)     (1,658)  
Ending balance at Sep. 30, 2020 $ 105,840 $ 8 $ 1,112,203 $ (1,759) $ (1,004,612)
Ending balance, Shares at Sep. 30, 2020   75,694