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Equity Incentive Plans - Additional Information (Detail) - USD ($) $ / shares in Units, $ in Thousands |  | 1 Months Ended | 12 Months Ended |  |
--- | --- | --- | --- | --- | ---
Jan. 01, 2024 | Oct. 31, 2017 | Aug. 31, 2017 | Dec. 31, 2023 | Dec. 31, 2022 | Dec. 31, 2021 | Jan. 31, 2024 | Feb. 29, 2020
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |  |  |  |  |  |  |  |
Common stock reserved for future issuance |  |  |  | 19,180,000 | 16,793,000 | 13,576,000 |  |
Stock options vesting period |  |  |  | 48 months |  |  |  |
Stock options vesting description |  |  |  | Options granted to employees on or after December 5, 2013 generally vest in installments of (i) 25% at the one-year anniversary and (ii) in either 36 equal monthly or 12 equal quarterly installments beginning in the thirteenth month after the initial vesting commencement date (as defined) subject to the employee’s continuous service with the Company. |  |  |  |
Aggregate number of stock options granted to purchase common stock |  |  |  | 838,000 | 1,300,000 | 2,700,000 |  |
Weighted - Average Grant Date Fair Value Per Option, Granted |  |  |  | $ 34.26 | $ 23.62 | $ 30.72 |  |
Aggregate intrinsic value of options exercised in period |  |  |  | $ 181,000 | $ 44,800 | $ 39,900 |  |
Fair market value of options vested in period |  |  |  | 46,800 | $ 59,000 | 53,200 |  |
Unrecognized compensation expense |  |  |  | $ 46,100 |  |  |  |
Estimated weighted-average period to recognize |  |  |  | 2 years 2 months 4 days |  |  |  |
Common stock, issued |  |  |  | 119,556,000 | 110,772,000 |  |  |
Common stock issued at average per share price |  |  |  | $ 20.11 |  |  |  |
Share-based compensation expense |  |  |  | $ 105,945 | $ 91,085 | $ 70,667 |  |
Restricted Stock Units [Member] |  |  |  |  |  |  |  |
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |  |  |  |  |  |  |  |
Unrecognized compensation expense |  |  |  | $ 155,500 |  |  |  |
Estimated weighted-average period to recognize |  |  |  | 2 years 7 months 6 days |  |  |  |
Aggregate intrinsic value of restricted grants vested |  |  |  | $ 55,300 |  |  |  |
Fair market value of restricted stock units vested |  |  |  | $ 42,200 |  |  |  |
Frist Anniversary [Member] |  |  |  |  |  |  |  |
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |  |  |  |  |  |  |  |
Stock options vesting percentage |  |  |  | 25.00% |  |  |  |
Second Anniversary [Member] |  |  |  |  |  |  |  |
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |  |  |  |  |  |  |  |
Stock options vesting percentage |  |  |  | 25.00% |  |  |  |
Third Anniversary [Member] |  |  |  |  |  |  |  |
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |  |  |  |  |  |  |  |
Stock options vesting percentage |  |  |  | 25.00% |  |  |  |
Fourth Anniversary [Member] |  |  |  |  |  |  |  |
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |  |  |  |  |  |  |  |
Stock options vesting percentage |  |  |  | 25.00% |  |  |  |
Subsequent Event [Member] |  |  |  |  |  |  |  |
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |  |  |  |  |  |  |  |
Shares issuable increased during the period | 200,000 |  |  |  |  |  |  |
Equity Incentive Plan 2010 [Member] |  |  |  |  |  |  |  |
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |  |  |  |  |  |  |  |
Common stock shares reserved for issuance |  |  | 6,188,466 |  |  |  |  |
Percentage of voting shares |  |  | 10.00% |  |  |  |  |
Options expire from issuance date |  |  | 10 years |  |  |  |  |
Equity Incentive Plan 2010 [Member] | Maximum [Member] |  |  |  |  |  |  |  |
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |  |  |  |  |  |  |  |
Percentage of estimated fair value per share of common stock on the date of grant |  |  | 100.00% |  |  |  |  |
Equity Incentive Plan 2010 [Member] | Minimum [Member] |  |  |  |  |  |  |  |
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |  |  |  |  |  |  |  |
Percentage price of each share of the fair value on date of grant |  |  | 110.00% |  |  |  |  |
2017 Stock Incentive Plan [Member] |  |  |  |  |  |  |  |
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |  |  |  |  |  |  |  |
Common stock shares reserved for issuance |  | 1,359,587 |  |  |  |  |  |
Percentage of voting shares |  | 4.00% |  |  |  |  |  |
Number of shares available for future grant |  | 299,568 |  | 6,497,120 |  |  |  |
Shares issuable increased during the period |  | 4,219,409 |  |  |  |  |  |
Common Stock Issuance Description |  |  |  | equal to the lowest of 4,219,409 shares of common stock, 4.0% of the number of shares of common stock outstanding on the first day of the fiscal year and an amount determined by the board of directors. |  |  |  |
Common stock reserved for future issuance |  |  |  | 16,989,000 | 14,271,000 | 11,014,000 |  |
2017 Stock Incentive Plan [Member] | Subsequent Event [Member] |  |  |  |  |  |  |  |
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |  |  |  |  |  |  |  |
Number of shares available for future grant |  |  |  |  |  |  | 4,219,409 |
2020 Inducement Stock Incentive Plan [Member] |  |  |  |  |  |  |  |
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |  |  |  |  |  |  |  |
Number of shares available for future grant |  |  |  | 354,466 |  |  |  |
Common stock reserved for future issuance |  |  |  | 1,638,000 | 1,857,000 | 1,761,000 |  | 750,000
2020 Inducement Stock Incentive Plan [Member] | Subsequent Event [Member] |  |  |  |  |  |  |  |
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |  |  |  |  |  |  |  |
Number of shares available for future grant | 1,950,000 |  |  |  |  |  |  |
2017 Employee Stock Purchase Plan [Member] |  |  |  |  |  |  |  |
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |  |  |  |  |  |  |  |
Common stock shares reserved for issuance |  | 468,823 |  |  |  |  |  |
Percentage of voting shares |  |  |  | 1.00% |  |  |  |
2017 Employee Stock Purchase Plan [Member] | Maximum [Member] |  |  |  |  |  |  |  |
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |  |  |  |  |  |  |  |
Common stock reserved for future issuance |  |  |  | 937,646 |  |  |  |
Employee Stock Purchase Plan [Member] |  |  |  |  |  |  |  |
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |  |  |  |  |  |  |  |
Percentage price of each share of the fair value on date of grant |  |  |  | 85.00% |  |  |  |
Number of shares available for future grant |  |  |  | 552,881 |  |  |  |
Common stock reserved for future issuance |  |  |  | 0 |  |  |  |
Percentage of earnings withheld to purchase shares of common stock |  |  |  | 15.00% |  |  |  |
Common stock, issued |  |  |  | 112,064 |  |  |  |
Common stock issued at average per share price |  |  |  | $ 48 |  |  |  |
Cash received from issuance of purchase rights |  |  |  | $ 5,400 |  |  |  |
Share-based compensation expense |  |  |  | $ 2,100 |  |  |  |

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