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Nature of Organization and Operations - Additional Information (Detail) - USD ($) $ / shares in Units, $ in Thousands |  |  |  | 12 Months Ended
--- | --- | --- | --- | ---
Feb. 22, 2023 | Mar. 28, 2022 | Nov. 18, 2021 | Dec. 31, 2023 | Dec. 31, 2022 | Dec. 31, 2021
Nature Of Organization And Operations [Line Items] |  |  |  |  |  |
Proceeds from follow-on public offering after deducting underwriting discounts and commissions |  |  |  |  | $ 380,120 | $ 380,363
Accumulated deficit |  |  |  | $ (2,837,488) | (2,308,860) |
Cash and cash equivalents |  |  |  | $ 351,185 | $ 551,801 | $ 640,192
Follow-on Public Offerings [Member] |  |  |  |  |  |
Nature Of Organization And Operations [Line Items] |  |  |  |  |  |
Issuance of common stock and pre-funded warrants in common stock offering, shares | 4,007,936 |  |  |  |  |
Pre funded warrant price | $ 62.9999 |  |  |  |  |
Common stock pre funded warrants per warrant | 0.0001 |  |  |  |  |
Issuance of common stock in follow-on offering, shares |  | 8,563,830 | 10,062,500 |  |  |
Price of common stock | $ 63 | $ 47 | $ 40.00 |  |  |
Proceeds from follow-on public offering after deducting underwriting discounts and commissions | $ 384,400 | $ 380,100 | $ 380,400 |  |  |
Underwriting discounts and commissions | 18,800 | 22,100 | 22,100 |  |  |
Offering Costs | $ 300 | $ 300 | $ 600 |  |  |
Over Allotment Option [Member] |  |  |  |  |  |
Nature Of Organization And Operations [Line Items] |  |  |  |  |  |
Issuance of common stock in follow-on offering, shares |  | 1,117,021 | 1,312,500 |  |  |
Price of common stock |  | $ 47 | $ 40.00 |  |  |
Common Stock [Member] |  |  |  |  |  |
Nature Of Organization And Operations [Line Items] |  |  |  |  |  |
Issuance of common stock and pre-funded warrants in common stock offering, shares |  |  |  | 4,008,000 |  |
Issuance of common stock in follow-on offering, shares |  |  |  |  | 8,564,000 | 10,063,000
Common Stock [Member] | Follow-on Public Offerings [Member] |  |  |  |  |  |
Nature Of Organization And Operations [Line Items] |  |  |  |  |  |
Issuance of common stock and pre-funded warrants in common stock offering, shares | 2,380,956 |  |  |  |  |
Common Stock [Member] | Over Allotment Option [Member] |  |  |  |  |  |
Nature Of Organization And Operations [Line Items] |  |  |  |  |  |
Issuance of common stock and pre-funded warrants in common stock offering, shares | 833,333 |  |  |  |  |

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