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Income Taxes (Tables) | 12 Months Ended
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Dec. 31, 2023
Income Tax Disclosure [Abstract] |
Components of Loss From Continuing Operation Before Provision for Income Taxes | The components of loss from continuing operations before provision for income taxes are as follows (in thousands):
| Year Ended December 31, |
| 2023 |  |  | 2022 |  |  | 2021 |
United States | $ | (48,495 | ) |  | $ | (82,815 | ) |  | $ | (314,673 | )
Foreign |  | (478,001 | ) |  |  | (568,688 | ) |  |  | (431,329 | )
Total | $ | (526,496 | ) |  | $ | (651,503 | ) |  | $ | (746,002 | )
Schedule of Provision for Income Tax Expense | Provision for income taxes for the years ended December 31, 2023, 2022, and 2021 are as follows (in thousands):
| Year Ended December 31, 2023 |  |  | Year Ended December 31, 2022 |  |  | Year Ended December 31, 2021 |
Current income tax expense: |  |  |  |  |  |  |  |
U.S. Federal | $ | — |  |  | $ | — |  |  | $ | — |
U.S. State and Local |  | 1,869 |  |  |  | 520 |  |  |  | 205 |
Foreign |  | 263 |  |  |  | 149 |  |  |  | 147 |
Total current income tax expense |  | 2,132 |  |  |  | 669 |  |  |  | 352 |
Deferred income tax expense: |  |  |  |  |  |  |  |
U.S. Federal |  | — |  |  |  | — |  |  |  | — |
U.S. State and Local |  | — |  |  |  | — |  |  |  | — |
Foreign |  | — |  |  |  | — |  |  |  | — |
Total deferred income tax expense |  | — |  |  |  | — |  |  |  | — |
Total tax expense | $ | 2,132 |  |  | $ | 669 |  |  | $ | 352 |
Schedule of Reconciliation Between U.S. Federal Statutory Rate and Effective Tax rate | A reconciliation between the U.S. federal statutory tax rate and the Company's effective tax rate is summarized as follows (in thousands):
| Year Ended December |
| 2023 |  |  | 2022 |  |  | 2021 |
| Amount |  |  | Percentage of income before income taxes |  |  | Amount |  |  | Percentage of income before income taxes |  |  | Amount |  |  | Percentage of income before income taxes |
Statutory U.S. federal income tax | $ | (110,564 | ) |  |  | 21.0 | % |  | $ | (136,816 | ) |  |  | 21.0 | % |  | $ | (156,660 | ) |  |  | 21.0 | %
Foreign tax rate differential |  | 42,100 |  |  |  | (8.0 | ) |  |  | 50,219 |  |  |  | (7.7 | ) |  |  | 38,677 |  |  |  | (5.2 | )
State income taxes, net of federal benefit |  | (13,438 | ) |  |  | 2.6 |  |  |  | 9,051 |  |  |  | (1.4 | ) |  |  | (14,145 | ) |  |  | 1.9 |
Change in valuation allowances |  | 119,592 |  |  |  | (23.2 | ) |  |  | 94,668 |  |  |  | (14.5 | ) |  |  | 133,668 |  |  |  | (17.9 | )
Tax credits |  | (11,566 | ) |  |  | 2.2 |  |  |  | (19,966 | ) |  |  | 3.0 |  |  |  | (20,005 | ) |  |  | 2.6 |
Share Based Compensation |  | (26,881 | ) |  |  | 5.1 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |
Change in state apportionment |  | — |  |  |  | — |  |  |  | (35 | ) |  |  | — |  |  |  | — |  |  |  | — |
Loss on debt conversion |  | — |  |  |  | — |  |  |  | 6,626 |  |  |  | (1.0 | ) |  |  | 19,548 |  |  |  | (2.6 | )
Permanent and other |  | 2,889 |  |  |  | (0.1 | ) |  |  | (3,078 | ) |  |  | 0.5 |  |  |  | (731 | ) |  |  | 0.1 |
Effective income tax provision | $ | 2,132 |  |  |  | (0.4 | ) |  | $ | 669 |  |  |  | (0.1 | ) |  | $ | 352 |  |  |  | (0.1 | )
Schedule of Deferred Tax Assets and Liabilities | The following table presents the principal components of the Company’s deferred tax assets and liabilities (in thousands):
| December 31, |
| 2023 |  |  | 2022 |
Deferred tax assets: |  |  |  |  |
Intangible assets | $ | 192,444 |  |  | $ | 187,839 |
Share-based compensation |  | 31,712 |  |  |  | 29,673 |
Net operating loss carryforwards |  | 329,135 |  |  |  | 228,985 |
Research and development credits |  | 67,667 |  |  |  | 57,419 |
Orphan drug credits |  | 34,023 |  |  |  | 30,160 |
Development derivative liability |  | 75,190 |  |  |  | 79,374 |
Convertible debt |  | 5,582 |  |  |  | 6,850 |
Fixed Assets |  | 18 |  |  |  | — |
Lease liability |  | 2,888 |  |  |  | 4,304 |
Accruals |  | 17,401 |  |  |  | 16,272 |
Total deferred tax assets |  | 756,060 |  |  |  | 640,876 |
Deferred tax liabilities: |  |  |  |  |
Fixed assets |  | — |  |  |  | (91 | )
Right-of-use asset |  | (2,672 | ) |  |  | (4,032 | )
481(a) adjustment |  | — |  |  |  | (233 | )
Total deferred tax liabilities |  | (2,672 | ) |  |  | (4,356 | )
Net deferred tax assets before allowance: |  | 753,388 |  |  |  | 636,520 |
Less valuation allowance |  | (753,388 | ) |  |  | (636,520 | )
Net deferred tax assets | $ | — |  |  | $ | — |

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