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v3.24.0.1

Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2023 | Dec. 31, 2022 | Dec. 31, 2021
Operating Activities |  |  |
Net loss | $ (528,628) | $ (652,172) | $ (746,354)
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |
Share-based compensation expense | 105,945 | 91,085 | 70,667
Loss on conversion of debt |  | 32,890 | 100,589
Loss from remeasurement of development derivative liability |  |  | 97,675
Loss on disposal of fixed assets | 120 |  |
Forfeiture of accrued interest in exchange of convertible notes |  | 1,287 | 4,171
Depreciation expense | 1,784 | 1,552 | 1,379
Amortization of right of use assets | (80) | (65) | 113
Amortization of discounts for convertible notes, net of financing costs | 297 | 459 | 964
Accretion of discount to development liability | 25,996 | 26,917 | 1,192
Changes in operating assets and liabilities: |  |  |
Accounts receivable | (198,715) | 2,375 | (10,103)
Inventory | (60,647) | (69,397) | (16,317)
Prepaid assets | (1,870) | (11,479) | (13,487)
Other current assets | 14,243 | 32,936 | (40,928)
Other assets | 11,700 | 17,490 | (12,782)
Accounts payable | 170 | 18,689 | 10,487
Accrued expenses | 34,950 | (6,312) | (10,392)
Net cash used in operating activities | (594,735) | (513,745) | (563,126)
Investing Activities |  |  |
Purchase of property and equipment | (773) | (1,524) | (1,103)
Proceeds from sale of fixed assets | 99 |  |
Purchase of available-for-sale securities |  | (331,863) | (171,281)
Proceeds from maturity of available-for-sale securities |  | 393,280 | 420,000
Net cash (used in) provided by investing activities | (674) | 59,893 | 247,616
Financing Activities |  |  |
Proceeds from issuance of common stock, net of issuance costs |  | 380,120 | 380,363
Proceeds from issuance of common stock, pre-funded warrant offering, net of issuance costs | 384,387 |  |
Payments for development derivative liability |  |  | (4,000)
Payments for development liability | (55,500) | (34,500) |
Proceeds from exercise of stock options | 71,274 | 21,483 | 14,691
Proceeds from issuance of common stock under employee share purchase plan | 5,378 | 4,238 | 2,970
Payments of employee tax withholding related to equity-based compensation | (11,040) | (5,682) | (1,788)
Net cash provided by financing activities | 394,499 | 365,659 | 392,236
Effect of exchange rate changes on cash and cash equivalents | 135 | (488) | (2,016)
Net (decrease) increase in cash and cash equivalents | (200,775) | (88,681) | 74,710
Cash, cash equivalents and restricted cash at beginning of period | 553,074 | 641,755 | 567,045
Cash, cash equivalents and restricted cash at end of period | 352,299 | 553,074 | 641,755
Reconciliation of cash, cash equivalents and restricted cash to the consolidated balance sheets: |  |  |
Cash and cash equivalents | 351,185 | 551,801 | 640,192
Restricted cash | 1,114 | 1,273 | 1,563
Total cash, cash equivalents, and restricted cash | 352,299 | 553,074 | 641,755
Supplemental disclosure of cash flow information: |  |  |
Cash paid for interest | 3,286 | 5,003 | 10,265
Cash paid for income taxes |  | 4,915 | 49
Proceeds from income tax refunds net of income taxes paid | $ 1,759 |  |
Convertible Notes exchanged for common stock |  | $ 98,086 | $ 328,017

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