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Consolidated Statements of Changes in Stockholder's Equity - USD ($)
shares in Thousands, $ in Thousands
Total
Cumulative Effect, Period of Adoption, Adjustment [Member]
Common Stock [Member]
Additional Paid-In Capital [Member]
Additional Paid-In Capital [Member]
Cumulative Effect, Period of Adoption, Adjustment [Member]
Accumulated Other Comprehensive Loss [Member]
Accumulated Deficit [Member]
Accumulated Deficit [Member]
Cumulative Effect, Period of Adoption, Adjustment [Member]
Beginning balance at Dec. 31, 2020 $ 204,557 $ (149,734) $ 8 $ 1,131,013 $ (165,747) $ (117) $ (926,347) $ 16,013
Beginning balance, Shares at Dec. 31, 2020     76,130          
Accounting Standards Update description ASU 2020-06              
Issuance of common stock in follow-on offering, net of offering costs $ 380,362   $ 1 380,361        
Issuance of common stock in follow-on offering, shares     10,063          
Issuance of common stock upon exercise of stock options 14,691     14,691        
Issuance of common stock upon exercise of stock options, shares     1,063          
Issuance of shares in exchange of Convertible Notes, including issuance cost 421,093   $ 1 421,092        
Issuance of shares in exchange of Convertible Notes, including issuance cost, shares     10,065          
Forfeiture of accrued interest in exchange of Convertible Notes 4,171     4,171        
Vesting of restricted stock units, net of shares withheld for taxes (1,788)     (1,788)        
Vesting of restricted stock units, net of shares withheld for taxes. shares     91          
Share-based compensation expense 70,667     70,667        
Issuance of common stock to employee stock purchase plan 2,970     2,970        
Issuance of common stock to employee stock purchase plan, shares     112          
Unrealized gain (loss) on available-for-sale investments 9         9    
Net loss (746,354)           (746,354)  
Foreign currency loss (1,982)         (1,982)    
Ending balance at Dec. 31, 2021 198,662   $ 10 1,857,430   (2,090) (1,656,688)  
Ending balance, Shares at Dec. 31, 2021     97,524          
Issuance of common stock in follow-on offering, net of offering costs 380,120   $ 1 380,119        
Issuance of common stock in follow-on offering, shares     8,564          
Issuance of common stock upon exercise of stock options 21,483     21,483        
Issuance of common stock upon exercise of stock options, shares     1,223          
Issuance of shares in exchange of Convertible Notes, including issuance cost 129,636     129,636        
Issuance of shares in exchange of Convertible Notes, including issuance cost, shares     3,073          
Forfeiture of accrued interest in exchange of Convertible Notes 1,287     1,287        
Vesting of restricted stock units, net of shares withheld for taxes (5,682)     (5,682)        
Vesting of restricted stock units, net of shares withheld for taxes. shares     252          
Share-based compensation expense 91,085     91,085        
Issuance of common stock to employee stock purchase plan 4,238     4,238        
Issuance of common stock to employee stock purchase plan, shares     136          
Unrealized gain (loss) on available-for-sale investments (1)         (1)    
Unrealized gain (loss) on pension benefit plan 1,646         1,646    
Net loss (652,172)           (652,172)  
Foreign currency loss (430)         (430)    
Ending balance at Dec. 31, 2022 169,872   $ 11 2,479,596   (875) (2,308,860)  
Ending balance, Shares at Dec. 31, 2022     110,772          
Issuance of common stock and pre-funded warrants in common stock offering 384,387   $ 1 384,386        
Issuance of common stock and pre-funded warrants in common stock offering, shares     4,008          
Issuance of common stock upon exercise of stock options $ 71,274     71,274        
Issuance of common stock upon exercise of stock options, shares 3,950   3,858          
Vesting of restricted stock units, net of shares withheld for taxes $ (11,040)     (11,040)        
Vesting of restricted stock units, net of shares withheld for taxes. shares     806          
Share-based compensation expense 105,945     105,945        
Issuance of common stock to employee stock purchase plan 5,378     5,378        
Issuance of common stock to employee stock purchase plan, shares     112          
Unrealized gain (loss) on pension benefit plan (2,618)         (2,618)    
Net loss (528,628)           (528,628)  
Foreign currency loss (49)         (49)    
Ending balance at Dec. 31, 2023 $ 194,521   $ 12 $ 3,035,539   $ (3,542) $ (2,837,488)  
Ending balance, Shares at Dec. 31, 2023     119,556