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Consolidated Statements of Operations and Comprehensive Loss - USD ($)
shares in Thousands, $ in Thousands
 12 Months Ended
Dec. 31, 2023
Dec. 31, 2022
Dec. 31, 2021
Revenue:      
Total product revenue, net $ 396,591 $ 75,422 $ 66,563
Operating expenses:      
Cost of sales 58,510 5,636 200
Research and development 354,387 387,236 345,869
Cost of research collaboration     75,000
License expense     5,000
General and administrative 500,815 277,163 176,771
Total operating expenses: 913,712 670,035 602,840
Net operating loss (517,121) (594,613) (536,277)
Loss on conversion of debt   (32,890) (100,589)
Loss from remeasurement of development derivative liability     (97,675)
Interest income 20,933 8,914 418
Interest expense (29,581) (32,626) (13,241)
Other(expense)/ income, net (727) (288) 1,362
Net loss before taxes (526,496) (651,503) (746,002)
Income tax expense 2,132 669 352
Net loss (528,628) (652,172) (746,354)
Other comprehensive income/(loss):      
Unrealized (loss)/gain on marketable securities   (1) 9
Unrealized (loss)/gain on pension plans (2,618) 1,646  
Foreign currency (loss) (49) (430) (1,982)
Total other comprehensive income/(loss) (2,667) 1,215 (1,973)
Comprehensive loss, net of tax $ (531,295) $ (650,957) $ (748,327)
Net loss per common share, basic $ (4.45) $ (6.15) $ (8.84)
Net loss per common share, diluted $ (4.45) $ (6.15) $ (8.84)
Weighted-average number of common shares used in net loss per common share, basic 118,678 106,114 84,421
Weighted-average number of common shares used in net loss per common share, diluted 118,678 106,114 84,421
Product revenue, net [Member]      
Revenue:      
Total product revenue, net $ 366,281 $ 65,092 $ 15,147
Licensing and other revenue [Member]      
Revenue:      
Total product revenue, net $ 30,310 $ 10,330 $ 51,416