The following table describes, for the quarterly period covered by this report, each trading arrangement for the sale or purchase of our securities adopted or terminated by our directors and officers that is either (1) a contract, instruction or written plan intended to satisfy the affirmative defense conditions of Rule 10b5-1(c), or a Rule 10b5-1 trading arrangement, or (2) a “non-Rule 10b5-1 trading arrangement” (as defined in Item 408(c) of Regulation S-K):


Name (Title)	Action Taken (Date of Action)	Type of Trading Arrangement	Nature of Trading Arrangement	Duration of Trading Arrangement	Aggregate Number of Securities
Alec Machiels Director	Adoption 2/29/2024	Rule 10b5-1 trading arrangement	Sale	Until 11/28/2025, or such earlier date upon which all transactions are completed or expire without execution	Up to 18,000 shares
David Watson General Counsel	Adoption 2/29/2024	Rule 10b5-1 trading arrangement	Sale	Until 2/28/2025, or such earlier date upon which all transactions are completed or expire without execution	Up to 23,872 shares
Mark DeLong Chief Business & Strategy Officer	Adoption 3/1/2024	Rule 10b5-1 trading arrangement	Sale	Until 2/28/2025, or such earlier date upon which all transactions are completed or expire without execution	Up to 24,799 shares
A. Sinclair Dunlop (1) Independent Director	Adoption 3/2/2024	non-Rule 10b5-1 trading arrangement	Sale	Until 12/31/2024, or such earlier date upon which all transactions are completed or expire without execution	Up to 174,000 shares
Cedric Francois President and Chief Executive Officer	Adoption 3/8/2024	Rule 10b5-1 trading arrangement	Sale	Until 5/30/2025 or such earlier date upon which all transactions are completed or expire without execution	Up to 592,034 shares
Caroline Baumal Chief Medical Officer	Adoption 3/13/2024	Rule 10b5-1 trading arrangement	Sale	Until 12/31/2024 or such earlier date upon which all transactions are completed or expire without execution	Up to 6,136 shares
Jeffrey R Eisele Chief Development Officer	Adoption 3/15/2024	Rule 10b5-1 trading arrangement	Sale	Until 2/28/2025 or such earlier date upon which all transactions are completed or expire without execution	Up to 207,256 shares
James Chopas Vice President, Corporate Controller and Chief Accounting Officer	Adoption 3/18/2024	Rule 10b5-1 trading arrangement	Sale	Until 8/30/2024 or such earlier date upon which all transactions are completed or expire without execution	Up to 4,000 shares
Karen L Lewis Chief People Officer	Adoption 3/19/2024	Rule 10b5-1 trading arrangement	Sale	Until 3/31/2025, or such earlier date upon which all transactions are completed or expire without execution	Up to 101,422 shares
Nur Nicholson Chief Technical Operations Officer	Adoption 3/30/2024	Rule 10b5-1 trading arrangement	Sale	Until 11/15/2024, or such earlier date upon which all transactions are completed or expire without execution	Up to 28,747 shares