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Income Taxes - Schedule of Deferred Tax Assets and Liabilities (Detail) - USD ($) $ in Thousands | Dec. 31, 2024 | Dec. 31, 2023
--- | --- | ---
Deferred tax assets: |  |
Intangible assets | $ 177,244 | $ 160,281
Research and development capitalization | 21,474 | 32,163
Share-based compensation | 38,494 | 31,712
Net operating loss carryforwards | 312,672 | 329,135
Research and development credits | 81,340 | 67,667
Orphan drug credits | 48,015 | 34,023
Development derivative liability |  | 75,190
Convertible debt | 1,021 | 5,582
Fixed Assets | 194 | 18
Lease liability | 3,026 | 2,888
Accruals | 7,668 | 9,998
Deferred Interest Expense | 1,974 |
Inventory Reserves | 31,476 | 6,317
UNICAP | 1,806 | 1,086
Total deferred tax assets | 726,404 | 756,060
Deferred tax liabilities: |  |
Right-of-use asset | (2,821) | (2,672)
Total deferred tax liabilities | (2,821) | (2,672)
Net deferred tax assets before allowance: | 723,583 | 753,388
Less valuation allowance | $ (723,583) | $ (753,388)

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