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License and Collaboration Agreements - Additional Information (Detail) |  |  | 1 Months Ended | 12 Months Ended | 50 Months Ended |  |  |
--- | --- | --- | --- | --- | --- | --- | --- | ---
Nov. 30, 2020 USD ($) | Oct. 27, 2020 USD ($) | Jan. 31, 2024 USD ($) | Oct. 31, 2023 USD ($) | Apr. 30, 2023 USD ($) | Jan. 31, 2023 USD ($) | Jun. 30, 2022 USD ($) | Apr. 30, 2022 USD ($) | Aug. 31, 2021 USD ($) | Jun. 30, 2021 Program | Dec. 31, 2024 USD ($) License | Dec. 31, 2023 USD ($) | Dec. 31, 2022 USD ($) | Dec. 31, 2024 USD ($) License | Jul. 31, 2021 USD ($) | Jan. 31, 2021 USD ($) | Oct. 31, 2020 USD ($)
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Development cost reimbursement received |  |  | $ 15,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Royalties receivable |  |  |  |  |  |  |  |  |  |  | $ 4,525,000 | $ 3,054,000 |  | $ 4,525,000 |  |  |
Number of licensed products | License |  |  |  |  |  |  |  |  |  |  | 2 |  |  | 2 |  |  |
Accrued expenses |  |  |  |  |  |  |  |  |  |  | $ 140,184,000 | 127,806,000 |  | $ 140,184,000 |  |  |
Up-front payment on first anniversary of agreement on June 30, 2022 |  |  |  |  |  |  | $ 25,000,000 |  |  |  |  |  |  |  |  |  |
SYFOVRE [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Royalty expense |  |  |  |  |  |  |  |  |  |  | 19,800,000 | 8,900,000 |  |  |  |  |
Regulatory milestone payments |  |  | 3,000,000 | $ 2,000,000 | $ 2,300,000 |  |  |  |  |  |  |  |  |  |  |  |
Regulatory milestone incurred |  |  |  |  |  |  |  |  |  |  |  | 5,000,000 |  |  |  |  |
Empaveli And Aspaveli [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Milestone payments based on annual sales milestones |  |  | 1,500,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Royalty expense |  |  |  |  |  |  |  |  |  |  | 6,400,000 | 4,800,000 | $ 2,700,000 |  |  |  |
Swedish Orphan Biovitrum AB (Publ) [Member] | Aspaveli [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Royalty revenue |  |  |  |  |  |  |  |  |  |  | $ 18,400,000 | 10,000,000 | $ 3,000,000 |  |  |  |
Collaboration and License Agreement [Member] | Swedish Orphan Biovitrum AB (Publ) [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Upfront payment | $ 250,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Milestone payment received for achievement of regulatory development milestone |  |  |  |  |  |  |  | $ 50,000,000 |  |  |  |  |  |  |  |  |
Development cost reimbursement received |  |  |  |  |  | $ 65,000,000 |  |  |  |  |  |  |  |  |  |  |
Waived Payment |  |  | 15,000,000 |  |  |  |  |  |  |  |  |  |  | 15,000,000 |  |  |
Royalties entitled to receive after first commercial sale of applicable licensed product period |  |  |  |  |  |  |  |  |  |  | 10 years |  |  |  |  |  |
Revenue recognized |  |  |  |  |  |  |  |  |  |  | $ 53,000,000 | 15,300,000 |  |  |  |  |
Contract research and development expense |  |  |  |  |  |  |  |  |  |  | 0 |  |  | 65,000,000 |  |  |
Remaining reimbursement payment |  |  | 15,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Contract research and development reimbursement commitment |  | $ 80,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Contract research and development current |  |  |  |  |  |  |  |  |  |  |  | $ 15,000,000 |  |  |  |  |
Collaboration and License Agreement [Member] | Swedish Orphan Biovitrum AB (Publ) [Member] | Maximum [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Aggregate milestone payments upon achievement of specified one time regulatory development and commercial milestone events |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 915,000,000
Development cost reimbursement |  |  |  |  |  |  |  |  |  |  | 80,000,000 |  |  |  |  |  |
University of Pennsylvania [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Development milestone achievement |  |  |  |  |  |  | $ 5,000,000 |  | $ 1,000,000 |  |  |  |  |  |  |  |
University of Pennsylvania [Member] | Empaveli And Aspaveli [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Milestone payments based on annual sales milestones |  |  |  |  |  | $ 1,000,000 |  |  |  |  |  |  |  |  |  |  |
University of Pennsylvania [Member] | Maximum [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Aggregate milestones payments |  |  |  |  |  |  |  |  |  |  | 3,200,000 |  |  | 3,200,000 |  |  |
Milestone payments based on annual sales milestones |  |  |  |  |  |  |  |  |  |  | 5,000,000 |  |  |  |  |  |
2010 License Agreement [Member] | Maximum [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Aggregate milestones payments |  |  |  |  |  |  |  |  |  |  | 1,700,000 |  |  | $ 1,700,000 |  |  |
Milestone payments based on annual sales milestones |  |  |  |  |  |  |  |  |  |  | $ 2,500,000 |  |  |  |  |  |
Sobi Agreement and Another Licensing Transaction [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Sublicense fee owed |  |  | $ 500,000 |  |  |  |  |  |  |  |  |  |  |  |  | $ 25,000,000 |
Research Collaboration Agreement [Member] | Beam [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaboration agreement term |  |  |  |  |  |  |  |  |  | 5 years |  |  |  |  |  |  |
Number of research programs | Program |  |  |  |  |  |  |  |  |  | 6 |  |  |  |  |  |  |
Up-front non-refundable payment |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 50,000,000 |  |
Collaboration agreement maximum extendable term |  |  |  |  |  |  | 2 years |  |  |  |  |  |  |  |  |  |

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