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Nature of Organization and Operations - Additional Information (Detail) - USD ($) $ / shares in Units, $ in Thousands |  |  |  | 12 Months Ended
--- | --- | --- | --- | ---
Feb. 27, 2024 | Feb. 22, 2023 | Mar. 28, 2022 | Dec. 31, 2024 | Dec. 31, 2023 | Dec. 31, 2022
Nature Of Organization And Operations [Line Items] |  |  |  |  |  |
Proceeds from follow-on public offering after deducting underwriting discounts and commissions |  |  |  |  |  | $ 380,120
Accumulated deficit |  |  |  | $ (3,035,366) | $ (2,837,488) |
Cash and cash equivalents |  |  |  | $ 411,290 | $ 351,185 | $ 551,801
Follow-on Public Offerings [Member] |  |  |  |  |  |
Nature Of Organization And Operations [Line Items] |  |  |  |  |  |
Issuance of common stock and pre-funded warrants in common stock offering, shares |  | 4,007,936 |  |  |  |
Pre funded warrant price |  | $ 62.9999 |  |  |  |
Common stock pre funded warrants per warrant |  | 0.0001 |  |  |  |
Issuance of common stock in follow-on offering, shares |  |  | 8,563,830 |  |  |
Price of common stock |  | $ 63 | $ 47 |  |  |
Proceeds from follow-on public offering after deducting underwriting discounts and commissions |  | $ 384,400 | $ 380,100 |  |  |
Underwriting discounts and commissions |  | 18,800 | 22,100 |  |  |
Offering Costs |  | $ 300 | $ 300 |  |  |
Over Allotment Option [Member] |  |  |  |  |  |
Nature Of Organization And Operations [Line Items] |  |  |  |  |  |
Issuance of common stock in follow-on offering, shares |  |  | 1,117,021 |  |  |
Price of common stock |  |  | $ 47 |  |  |
Capped Call Transactions [Member] |  |  |  |  |  |
Nature Of Organization And Operations [Line Items] |  |  |  |  |  |
Proceeds from follow-on public offering after deducting underwriting discounts and commissions | $ 98,800 |  |  |  |  |
Common Stock [Member] |  |  |  |  |  |
Nature Of Organization And Operations [Line Items] |  |  |  |  |  |
Issuance of common stock and pre-funded warrants in common stock offering, shares |  |  |  | 80,956 | 4,008,000 |
Issuance of common stock in follow-on offering, shares |  |  |  |  |  | 8,564,000
Shares issued upon exercise of pre-funded warrants |  |  |  | 2,299,991 |  |
Common Stock [Member] | Follow-on Public Offerings [Member] |  |  |  |  |  |
Nature Of Organization And Operations [Line Items] |  |  |  |  |  |
Issuance of common stock and pre-funded warrants in common stock offering, shares |  | 2,380,956 |  |  |  |
Common Stock [Member] | Over Allotment Option [Member] |  |  |  |  |  |
Nature Of Organization And Operations [Line Items] |  |  |  |  |  |
Issuance of common stock and pre-funded warrants in common stock offering, shares |  | 833,333 |  |  |  |

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