XML 51 R37.htm IDEA: XBRL DOCUMENT
v3.25.0.1

Equity Incentive Plans (Tables) | 12 Months Ended
--- | ---
Dec. 31, 2024
Share-Based Payment Arrangement [Abstract] |
Summary of Shares of Common Stock Reserved for Future Issuance | The Company has reserved the following shares of common stock for future issuance (in thousands):
| December 31, |
| 2024 |  |  | 2023 |  |  | 2022 |
Shares reserved under 2017 Equity Incentive Plan |  | 20,062 |  |  |  | 16,989 |  |  |  | 14,271 |
Shares reserved under 2017 Employee Stock Purchase Plan |  | 411 |  |  |  | 553 |  |  |  | 665 |
Shares reserved under 2020 Inducement Stock Incentive Plan |  | 1,627 |  |  |  | 1,638 |  |  |  | 1,857 |
Total |  | 22,100 |  |  |  | 19,180 |  |  |  | 16,793 |
Summary of Share-based Compensation Expense | Total share-based compensation expense related to the various plans during the years ended was as follows (in thousands):
| Year Ended December 31, |
| 2024 |  |  | 2023 |  |  | 2022 |
Research and development | $ | 41,267 |  |  | $ | 45,644 |  |  | $ | 42,052 |
Selling, general and administrative |  | 72,861 |  |  |  | 60,301 |  |  |  | 49,033 |
Total share-based compensation expense | $ | 114,128 |  |  | $ | 105,945 |  |  | $ | 91,085 |
Summary of Stock Option Activity | The following table summarizes the Company’s stock option activity:
|  |  |  |  | Weighted - |  |  | Weighted - |  |  |  |
|  |  |  |  | Average |  |  | Average |  |  | Aggregate |
|  |  |  |  | Exercise |  |  | Contractual |  |  | Intrinsic |
|  | Shares |  |  | Price |  |  | Life |  |  | Value |
|  | (in thousands) |  |  | Per Share |  |  | (in years) |  |  | (in thousands) |
Outstanding, December 31, 2023 |  |  | 8,664 |  |  | $ | 30.65 |  |  |  | 6.01 |  |  | $ | 253,933 |
Granted |  |  | 685 |  |  |  | 64.54 |  |  |  |  |  |  |
Exercised |  |  | (1,080 | ) |  |  | 13.26 |  |  |  |  |  |  |
Forfeited |  |  | (221 | ) |  |  | 49.19 |  |  |  |  |  |  |
Outstanding, December 31, 2024 |  |  | 8,048 |  |  | $ | 35.36 |  |  |  |  |  |  |
Options exercisable, December 31, 2024 |  |  | 6,713 |  |  | $ | 31.39 |  |  |  | 4.79 |  |  | $ | 48,477 |
Expected to vest, December 31, 2024 |  |  | 1,335 |  |  | $ | 55.36 |  |  |  | 8.25 |  |  | $ | — |
Summary of Assumption Used to Estimate the Grant Date Fair Value | The assumptions used in the Black-Scholes model to estimate the grant date fair value are as follows:
| Year Ended December 31,
| 2024 |  | 2023 |  | 2022
Risk-free interest rate | 3.94 - 4.36% |  | 3.50 - 4.01% |  | 1.15 - 3.37%
Dividend yield | 0% |  | 0% |  | 0%
Volatility | 71.91 - 77.01% |  | 68.4 - 71.0% |  | 68.3 - 70.4%
Expected terms (years) | 3.81 - 6.08 |  | 3.81 - 6.08 |  | 3.81 - 6.08
Schedule of Unvested Restricted Stock Units Activity | The following table summarizes the Company’s RSU's activity:
|  | Number of Stock Units (in thousands) |  |  | Weighted Average Grant Date Fair Value Per Share |
Unvested Balance at December 31, 2023 |  |  | 4,301 |  |  | $ | 47.48 |
Granted |  |  | 1,570 |  |  |  | 62.77 |
Vested |  |  | (1,419 | ) |  |  | 46.19 |
Forfeited |  |  | (491 | ) |  |  | 54.10 |
Unvested Balance at December 31, 2024 |  |  | 3,961 |  |  |  | 53.19 |

X
- Definition Summary of common stock reserved for future issuance. + References No definition available. + Details
Name: | apls_SummaryOfCommonStockReservedForFutureIssuanceTableTextBlock
Namespace Prefix: | apls_
Data Type: | dtr-types:textBlockItemType
Balance Type: | na
Period Type: | duration

X
- References No definition available. + Details
Name: | us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract
Namespace Prefix: | us-gaap_
Data Type: | xbrli:stringItemType
Balance Type: | na
Period Type: | duration

X
- Definition Tabular disclosure of allocation of amount expensed and capitalized for award under share-based payment arrangement to statement of income or comprehensive income and statement of financial position. Includes, but is not limited to, corresponding line item in financial statement. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (h)(1) -Publisher FASB -URI https://asc.fasb.org/1943274/2147480429/718-10-50-2 + Details
Name: | us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTextBlock
Namespace Prefix: | us-gaap_
Data Type: | dtr-types:textBlockItemType
Balance Type: | na
Period Type: | duration

X
- Definition Tabular disclosure of the changes in outstanding nonvested restricted stock units. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Topic 718 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 2 -Subparagraph (c)(2) -Publisher FASB -URI https://asc.fasb.org/1943274/2147480429/718-10-50-2 + Details
Name: | us-gaap_ScheduleOfNonvestedRestrictedStockUnitsActivityTableTextBlock
Namespace Prefix: | us-gaap_
Data Type: | dtr-types:textBlockItemType
Balance Type: | na
Period Type: | duration

X
- Definition Tabular disclosure for stock option plans. Includes, but is not limited to, outstanding awards at beginning and end of year, grants, exercises, forfeitures, and weighted-average grant date fair value. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Topic 718 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 2 -Subparagraph (c)(1) -Publisher FASB -URI https://asc.fasb.org/1943274/2147480429/718-10-50-2 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Section 50 -Paragraph 2 -Subparagraph (d) -SubTopic 10 -Topic 718 -Publisher FASB -URI https://asc.fasb.org/1943274/2147480429/718-10-50-2 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Section 50 -Paragraph 2 -Subparagraph (e) -SubTopic 10 -Topic 718 -Publisher FASB -URI https://asc.fasb.org/1943274/2147480429/718-10-50-2 + Details
Name: | us-gaap_ScheduleOfShareBasedCompensationStockOptionsActivityTableTextBlock
Namespace Prefix: | us-gaap_
Data Type: | dtr-types:textBlockItemType
Balance Type: | na
Period Type: | duration

X
- Definition Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Topic 718 -SubTopic 10 -Subparagraph (f)(2) -Name Accounting Standards Codification -Paragraph 2 -Section 50 -Publisher FASB -URI https://asc.fasb.org/1943274/2147480429/718-10-50-2 + Details
Name: | us-gaap_ScheduleOfShareBasedPaymentAwardStockOptionsValuationAssumptionsTableTextBlock
Namespace Prefix: | us-gaap_
Data Type: | dtr-types:textBlockItemType
Balance Type: | na
Period Type: | duration