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Equity Incentive Plans (Tables)

12 Months Ended

Dec. 31, 2024

Share-Based Payment Arrangement [Abstract]

Summary of Shares of Common Stock Reserved for Future Issuance

The Company has reserved the following shares of common stock for future issuance (in thousands):

	December 31,
	2024				2023				2022
Shares reserved under 2017 Equity Incentive Plan		20,062				16,989				14,271
Shares reserved under 2017 Employee Stock Purchase Plan		411				553				665
Shares reserved under 2020 Inducement Stock Incentive Plan		1,627				1,638				1,857
Total		22,100				19,180				16,793

Summary of Share-based Compensation Expense

Total share-based compensation expense related to the various plans during the years ended was as follows (in thousands):

	Year Ended December 31,
	2024				2023				2022
Research and development	$	41,267			$	45,644			$	42,052
Selling, general and administrative		72,861				60,301				49,033
Total share-based compensation expense	$	114,128			$	105,945			$	91,085

Summary of Stock Option Activity

The following table summarizes the Company’s stock option activity:

						Weighted -				Weighted -
						Average				Average				Aggregate
						Exercise				Contractual				Intrinsic
		Shares				Price				Life				Value
		(in thousands)				Per Share				(in years)				(in thousands)
Outstanding, December 31, 2023			8,664			$	30.65				6.01			$	253,933
Granted			685				64.54
Exercised			(1,080	)			13.26
Forfeited			(221	)			49.19
Outstanding, December 31, 2024			8,048			$	35.36
Options exercisable, December 31, 2024			6,713			$	31.39				4.79			$	48,477
Expected to vest, December 31, 2024			1,335			$	55.36				8.25			$	—

Summary of Assumption Used to Estimate the Grant Date Fair Value

The assumptions used in the Black-Scholes model to estimate the grant date fair value are as follows:

	Year Ended December 31,
	2024		2023		2022
Risk-free interest rate	3.94 - 4.36%		3.50 - 4.01%		1.15 - 3.37%
Dividend yield	0%		0%		0%
Volatility	71.91 - 77.01%		68.4 - 71.0%		68.3 - 70.4%
Expected terms (years)	3.81 - 6.08		3.81 - 6.08		3.81 - 6.08

Schedule of Unvested Restricted Stock Units Activity

The following table summarizes the Company’s RSU's activity:

		Number of Stock Units  (in thousands)				Weighted Average Grant Date Fair Value Per Share
Unvested Balance at December 31, 2023			4,301			$	47.48
Granted			1,570				62.77
Vested			(1,419	)			46.19
Forfeited			(491	)			54.10
Unvested Balance at December 31, 2024			3,961				53.19

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