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Consolidated Statements of Operations and Comprehensive Loss - USD ($)
shares in Thousands, $ in Thousands
 12 Months Ended
Dec. 31, 2024
Dec. 31, 2023
Dec. 31, 2022
Revenue:      
Revenue $ 781,367 $ 396,591 $ 75,422
Operating expenses:      
Cost of sales 117,723 58,510 5,636
Research and development 327,570 354,387 387,236
Selling, general and administrative 501,053 500,815 277,163
Total operating expenses: 946,346 913,712 670,035
Net operating loss (164,979) (517,121) (594,613)
Loss on conversion of debt     (32,890)
Loss on extinguishment of development liability (1,949)    
Interest income 12,773 20,933 8,914
Interest expense (40,391) (29,581) (32,626)
Other expense, net (2,170) (727) (288)
Net loss before taxes (196,716) (526,496) (651,503)
Income tax expense 1,162 2,132 669
Net loss (197,878) (528,628) (652,172)
Other comprehensive income/(loss):      
Unrealized (loss)/gain on marketable securities     (1)
Unrealized (loss)/gain on pension plans 591 (2,618) 1,646
Foreign currency translation (357) (49) (430)
Total other comprehensive income/(loss) 234 (2,667) 1,215
Comprehensive loss, net of tax $ (197,644) $ (531,295) $ (650,957)
Net loss per common share, basic $ (1.6) $ (4.45) $ (6.15)
Net loss per common share, diluted $ (1.6) $ (4.45) $ (6.15)
Weighted-average number of common shares used in net loss per common share, basic 123,905 118,678 106,114
Weighted-average number of common shares used in net loss per common share, diluted 123,905 118,678 106,114
Product revenue, net [Member]      
Revenue:      
Revenue $ 709,954 $ 366,281 $ 65,092
Licensing and other revenue [Member]      
Revenue:      
Revenue $ 71,413 $ 30,310 $ 10,330