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Nature of Organization and Operations - Additional Information (Detail) - USD ($)
$ / shares in Units, $ in Thousands
 12 Months Ended
Feb. 27, 2024
Feb. 22, 2023
Mar. 28, 2022
Dec. 31, 2024
Dec. 31, 2023
Dec. 31, 2022
Nature Of Organization And Operations [Line Items]            
Proceeds from follow-on public offering after deducting underwriting discounts and commissions           $ 380,120
Accumulated deficit       $ (3,035,366) $ (2,837,488)  
Cash and cash equivalents       $ 411,290 $ 351,185 $ 551,801
Follow-on Public Offerings [Member]            
Nature Of Organization And Operations [Line Items]            
Issuance of common stock and pre-funded warrants in common stock offering, shares   4,007,936        
Pre funded warrant price   $ 62.9999        
Common stock pre funded warrants per warrant   0.0001        
Issuance of common stock in follow-on offering, shares     8,563,830      
Price of common stock   $ 63 $ 47      
Proceeds from follow-on public offering after deducting underwriting discounts and commissions   $ 384,400 $ 380,100      
Underwriting discounts and commissions   18,800 22,100      
Offering Costs   $ 300 $ 300      
Over Allotment Option [Member]            
Nature Of Organization And Operations [Line Items]            
Issuance of common stock in follow-on offering, shares     1,117,021      
Price of common stock     $ 47      
Capped Call Transactions [Member]            
Nature Of Organization And Operations [Line Items]            
Proceeds from follow-on public offering after deducting underwriting discounts and commissions $ 98,800          
Common Stock [Member]            
Nature Of Organization And Operations [Line Items]            
Issuance of common stock and pre-funded warrants in common stock offering, shares       80,956 4,008,000  
Issuance of common stock in follow-on offering, shares           8,564,000
Shares issued upon exercise of pre-funded warrants       2,299,991    
Common Stock [Member] | Follow-on Public Offerings [Member]            
Nature Of Organization And Operations [Line Items]            
Issuance of common stock and pre-funded warrants in common stock offering, shares   2,380,956        
Common Stock [Member] | Over Allotment Option [Member]            
Nature Of Organization And Operations [Line Items]            
Issuance of common stock and pre-funded warrants in common stock offering, shares   833,333