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Product Revenues, Accounts Receivable, and Reserves for Product Sales - Schedule of Disaggregation of Product Revenue by Major Source (Detail) - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2024
Dec. 31, 2023
Dec. 31, 2022
Product Revenues Accounts Receivable And Reserves For Product Sales [Line Items]      
Total product revenue, net $ 781,367 $ 396,591 $ 75,422
EMPAVELI      
Product Revenues Accounts Receivable And Reserves For Product Sales [Line Items]      
Total product revenue, net 98,091 91,033 65,092
SYFOVRE [Member]      
Product Revenues Accounts Receivable And Reserves For Product Sales [Line Items]      
Total product revenue, net 611,863 275,248  
Product revenue, net [Member]      
Product Revenues Accounts Receivable And Reserves For Product Sales [Line Items]      
Total product revenue, net $ 709,954 $ 366,281 $ 65,092