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Equity Incentive Plans - Additional Information (Detail) - USD ($)
$ / shares in Units, $ in Thousands
 1 Months Ended 12 Months Ended
Jan. 01, 2024
Oct. 31, 2017
Aug. 31, 2017
Dec. 31, 2024
Dec. 31, 2023
Dec. 31, 2022
Jan. 31, 2025
Jan. 01, 2025
Feb. 29, 2020
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                  
Shares issuable increased during the period 200,000                
Common stock reserved for future issuance       22,100,000 19,180,000 16,793,000      
Stock options vesting period       48 months          
Stock options vesting description       Options granted to employees vest over 48 months in installments of (i) 25% at the one-year anniversary and (ii) in either 36 equal monthly or 12 equal quarterly installments beginning in the thirteenth month after the initial vesting commencement date (as defined) subject to the employee’s continuous service with the Company.          
Aggregate number of stock options granted to purchase common stock       685,000 800,000 1,300,000      
Weighted - Average Grant Date Fair Value Per Option, Granted       $ 42.61 $ 34.26 $ 23.62      
Aggregate intrinsic value of options exercised in period       $ 46,000 $ 181,000 $ 44,800      
Unrecognized compensation expense       $ 37,300          
Estimated weighted-average period to recognize       2 years 3 months 18 days          
Common stock, issued       124,495,000 119,556,000        
Common stock issued at average per share price       $ 13.26          
Share-based compensation expense       $ 114,128 $ 105,945 91,085      
Restricted Stock Units [Member]                  
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                  
Unrecognized compensation expense       $ 145,900          
Estimated weighted-average period to recognize       2 years 4 months 24 days          
Fair market value of restricted stock units vested       $ 65,500 $ 42,200 $ 15,300      
Equity Incentive Plan 2010 [Member]                  
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                  
Common stock shares reserved for issuance     6,188,466            
Percentage of voting shares     10.00%            
Options expire from issuance date     10 years            
Equity Incentive Plan 2010 [Member] | Maximum [Member]                  
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                  
Percentage of estimated fair value per share of common stock on the date of grant     100.00%            
Equity Incentive Plan 2010 [Member] | Minimum [Member]                  
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                  
Percentage price of each share of the fair value on date of grant     110.00%            
2017 Stock Incentive Plan [Member]                  
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                  
Common stock shares reserved for issuance   1,359,587              
Percentage of voting shares   4.00%              
Number of shares available for future grant   299,568   9,726,725          
Shares issuable increased during the period   4,219,409              
Common Stock Issuance Description       equal to the lowest of 4,219,409 shares of common stock, 4.0% of the number of shares of common stock outstanding on the first day of the fiscal year and an amount determined by the board of directors.          
Common stock reserved for future issuance       20,062,000 16,989,000 14,271,000      
2017 Stock Incentive Plan [Member] | Subsequent Event [Member]                  
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                  
Number of shares available for future grant             4,219,409    
Common stock reserved for future issuance             4,219,409    
2020 Inducement Stock Incentive Plan [Member]                  
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                  
Number of shares available for future grant 1,950,000     528,595          
Common stock reserved for future issuance       1,627,000 1,638,000 1,857,000     750,000
2020 Inducement Stock Incentive Plan [Member] | Subsequent Event [Member]                  
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                  
Number of shares available for future grant               0  
2017 Employee Stock Purchase Plan [Member]                  
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                  
Common stock shares reserved for issuance   468,823              
Percentage of voting shares       1.00%          
2017 Employee Stock Purchase Plan [Member] | Maximum [Member]                  
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                  
Common stock reserved for future issuance       937,646          
Employee Stock Purchase Plan [Member]                  
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                  
Percentage price of each share of the fair value on date of grant       85.00%          
Number of shares available for future grant       410,940          
Common stock reserved for future issuance       0          
Percentage of earnings withheld to purchase shares of common stock       15.00%          
Common stock, issued       141,941          
Common stock issued at average per share price       $ 31.77          
Cash received from issuance of purchase rights       $ 4,500          
Share-based compensation expense       $ 2,000