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Product Revenues, Accounts Receivable, and Reserves for Product Sales - Schedule of Factoring of Accounts Receivable and Associated Fees (Details - USD ($) $ in Thousands | 3 Months Ended
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Mar. 31, 2025 | Mar. 31, 2024
Product Revenues Accounts Receivable And Reserves For Product Sales [Abstract] |  |
Accounts receivable sold | $ 99,735 | $ 0
Less: factoring fees | (1,212) | 0
Net cash proceeds | $ 98,523 | $ 0

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- Definition Payment of factoring fees. + References No definition available. + Details
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Namespace Prefix: | apls_
Data Type: | xbrli:monetaryItemType
Balance Type: | credit
Period Type: | duration

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- Definition Proceeds from sale of other receivables net of factoring fees. + References No definition available. + Details
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Namespace Prefix: | apls_
Data Type: | xbrli:monetaryItemType
Balance Type: | debit
Period Type: | duration

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- Definition Product revenues, accounts receivable, and reserves for product sales. + References No definition available. + Details
Name: | apls_ProductRevenuesAccountsReceivableAndReservesForProductSalesAbstract
Namespace Prefix: | apls_
Data Type: | xbrli:stringItemType
Balance Type: | na
Period Type: | duration

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- Definition Amount of cash inflow from the sale of receivables classified as other. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 12 -Publisher FASB -URI https://asc.fasb.org/1943274/2147482740/230-10-45-12 + Details
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Namespace Prefix: | us-gaap_
Data Type: | xbrli:monetaryItemType
Balance Type: | debit
Period Type: | duration