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Nature of Organization and Operations - Additional Information (Detail) - USD ($) $ in Thousands | 1 Months Ended |  |  |
--- | --- | --- | --- | ---
Jul. 31, 2025 | Jun. 30, 2025 | Dec. 31, 2024 | Jun. 30, 2024
Nature Of Organization And Operations [Line Items] |  |  |  |
Cash and cash equivalents |  | $ 370,036 | $ 411,290 | $ 360,087
Accumulated deficit |  | $ (3,169,742) | $ (3,035,366) |
Swedish Orphan Biovitrum AB (Publ) [Member] | Subsequent Event [Member] | Royalty Agreement [Member] |  |  |  |
Nature Of Organization And Operations [Line Items] |  |  |  |
Proceeds received from royalty buy-down agreement | $ 275,000 |  |  |

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