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Segment Information | 6 Months Ended
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Jun. 30, 2025
Segment Reporting [Abstract] |
Segment Information | 13. Segment Information The Company operates as a single operating segment, which is the discovery, development and commercialization of novel therapeutic compounds to treat diseases with high unmet needs through the inhibition of the complement system, which is an integral component of the immune system. The Company defines its segment on the basis in which internally reported financial information is regularly reviewed by the chief operating decision maker ("CODM") to analyze financial performance, make decisions, and allocate resources. The CODM is the chief executive officer (“CEO”). The Company’s CODM reviews consolidated net loss for purposes of assessing performance, making operating decisions, allocating resources, and planning and forecasting for future periods. The following table presents information about reported segment revenue, segment loss, and significant segment expenses as provided to the CODM with respect to the Company’s single operating segment for the three and six months ended June 30, 2025 and 2024:
| For the Three Months Ended June 30, |  |  | For the Six Months Ended June 30, |
| 2025 |  |  | 2024 |  |  | 2025 |  |  | 2024 |
Revenue | $ | 178,494 |  |  | $ | 199,685 |  |  | $ | 345,291 |  |  | $ | 372,009 |
Less: |  |  |  |  |  |  |  |  |  |  |
Internal research and development costs |  | 21,692 |  |  |  | 21,143 |  |  |  | 44,642 |  |  |  | 40,867 |
Internal selling, general and administrative costs |  | 43,527 |  |  |  | 43,788 |  |  |  | 90,194 |  |  |  | 90,128 |
External commercial costs |  | 60,081 |  |  |  | 59,207 |  |  |  | 117,074 |  |  |  | 117,879 |
External research and development costs |  | 33,871 |  |  |  | 43,163 |  |  |  | 85,590 |  |  |  | 94,154 |
External general and administrative costs |  | 11,787 |  |  |  | 8,738 |  |  |  | 21,846 |  |  |  | 16,867 |
Other segment items (1) |  | 13,479 |  |  |  | 25,024 |  |  |  | 48,007 |  |  |  | 45,733 |
Share-based compensation expense |  | 27,197 |  |  |  | 29,990 |  |  |  | 54,571 |  |  |  | 60,339 |
Interest income |  | (2,607 | ) |  |  | (3,184 | ) |  |  | (5,265 | ) |  |  | (6,488 | )
Interest expense |  | 11,152 |  |  |  | 9,359 |  |  |  | 22,201 |  |  |  | 16,326 |
Income tax expense |  | 466 |  |  |  | 114 |  |  |  | 807 |  |  |  | 284 |
Net loss | $ | (42,151 | ) |  | $ | (37,657 | ) |  | $ | (134,376 | ) |  | $ | (104,080 | )
(1) Other segment items include cost of sales and other expenses.

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- Definition The entire disclosure for reporting segments including data and tables. Reportable segments include those that meet any of the following quantitative thresholds a) it's reported revenue, including sales to external customers and intersegment sales or transfers is 10 percent or more of the combined revenue, internal and external, of all operating segments b) the absolute amount of its reported profit or loss is 10 percent or more of the greater, in absolute amount of 1) the combined reported profit of all operating segments that did not report a loss or 2) the combined reported loss of all operating segments that did report a loss c) its assets are 10 percent or more of the combined assets of all operating segments. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Topic 280 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 21 -Subparagraph (b) -Publisher FASB -URI https://asc.fasb.org/1943274/2147482810/280-10-50-21 Reference 2: http://www.xbrl.org/2003/role/disclosureRef -Topic 280 -SubTopic 10 -Name 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