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Nature of Organization and Operations - Additional Information (Detail) - USD ($) $ in Thousands	1 Months Ended
	Jul. 31, 2025	Jun. 30, 2025	Dec. 31, 2024	Jun. 30, 2024
Nature Of Organization And Operations [Line Items]
Cash and cash equivalents		$ 370,036	$ 411,290	$ 360,087
Accumulated deficit		$ (3,169,742)	$ (3,035,366)
Swedish Orphan Biovitrum AB (Publ) [Member] | Subsequent Event [Member] | Royalty Agreement [Member]
Nature Of Organization And Operations [Line Items]
Proceeds received from royalty buy-down agreement	$ 275,000

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