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Segment Information - Schedule of Segment Revenue, Segment Profit or Loss and Significant Segment Expenses (Detail) - USD ($)
$ in Thousands
 3 Months Ended 6 Months Ended
Jun. 30, 2025
Mar. 31, 2025
Jun. 30, 2024
Mar. 31, 2024
Jun. 30, 2025
Jun. 30, 2024
Less:            
Interest income $ (2,607)   $ (3,184)   $ (5,265) $ (6,488)
Interest expense 11,152   9,359   22,201 16,326
Income tax expense 466   114   807 284
Net loss (42,151) $ (92,225) (37,657) $ (66,423) (134,376) (104,080)
Reported Segment [Member]            
Segment Reporting Information [Line Items]            
Revenue 178,494   199,685   345,291 372,009
Less:            
Internal research and development costs 21,692   21,143   44,642 40,867
Internal selling, general and administrative costs 43,527   43,788   90,194 90,128
External commercial costs 60,081   59,207   117,074 117,879
External research and development costs 33,871   43,163   85,590 94,154
External general and administrative costs 11,787   8,738   21,846 16,867
Other segment items [1] 13,479   25,024   48,007 45,733
Share-based compensation expense 27,197   29,990   54,571 60,339
Interest income (2,607)   (3,184)   (5,265) (6,488)
Interest expense 11,152   9,359   22,201 16,326
Income tax expense 466   114   807 284
Net loss $ (42,151)   $ (37,657)   $ (134,376) $ (104,080)
[1] Other segment items include cost of sales and other expenses.