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Product Revenues, Accounts Receivable, and Reserves for Product Sales - Schedule of Factoring of Accounts Receivable and Associated Fees (Details) - USD ($) $ in Thousands | 3 Months Ended | 9 Months Ended
--- | --- | ---
Sep. 30, 2025 | Sep. 30, 2024 | Sep. 30, 2025 | Sep. 30, 2024
Revenue, Major Customer [Line Items] |  |  |  |
Accounts receivable sold | $ 0 | $ 56,590 | $ 199,448 | $ 56,590
Less: factoring fees | 0 | (672) | (2,433) | (672)
Net cash proceeds | $ 0 | $ 55,918 | $ 197,015 | $ 55,918

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- Definition Payment of factoring fees. + References No definition available. + Details
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Balance Type: | credit
Period Type: | duration

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- Definition Proceeds from sale of other receivables net of factoring fees. + References No definition available. + Details
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Namespace Prefix: | apls_
Data Type: | xbrli:monetaryItemType
Balance Type: | debit
Period Type: | duration

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- Definition Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table. + References No definition available. + Details
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Namespace Prefix: | us-gaap_
Data Type: | xbrli:stringItemType
Balance Type: | na
Period Type: | duration

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- Definition Amount of cash inflow from the sale of receivables classified as other. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 12 -Publisher FASB -URI https://asc.fasb.org/1943274/2147482740/230-10-45-12 + Details
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