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v3.25.3

Segment Information - Schedule of Segment Revenue, Segment Profit or Loss and Significant Segment Expenses (Detail) - USD ($) $ in Thousands | 3 Months Ended | 9 Months Ended
--- | --- | ---
Sep. 30, 2025 | Jun. 30, 2025 | Mar. 31, 2025 | Sep. 30, 2024 | Jun. 30, 2024 | Mar. 31, 2024 | Sep. 30, 2025 | Sep. 30, 2024
Less: |  |  |  |  |  |  |  |  |
Interest income |  | $ (4,376) |  |  | $ (2,889) |  |  | $ (9,641) | $ (9,377)
Interest expense |  | 11,279 |  |  | 12,532 |  |  | 33,480 | 28,857
Income tax expense |  | 602 |  |  | 592 |  |  | 1,409 | 876
Net income/(loss) |  | 215,715 | $ (42,151) | $ (92,225) | (57,445) | $ (37,657) | $ (66,423) | 81,339 | (161,525)
Reported Segment [Member] |  |  |  |  |  |  |  |  |
Segment Reporting Information [Line Items] |  |  |  |  |  |  |  |  |
Revenue |  | 458,578 |  |  | 196,830 |  |  | 803,869 | 568,839
Less: |  |  |  |  |  |  |  |  |
Internal research and development costs |  | 19,225 |  |  | 20,217 |  |  | 63,867 | 61,084
Internal selling, general and administrative costs |  | 44,938 |  |  | 42,814 |  |  | 135,133 | 132,942
External commercial costs |  | 59,690 |  |  | 55,392 |  |  | 176,764 | 173,271
External research and development costs |  | 36,982 |  |  | 56,499 |  |  | 122,573 | 150,653
External general and administrative costs |  | 21,842 |  |  | 8,154 |  |  | 43,689 | 25,022
Other segment items | [1] | 24,495 |  |  | 33,489 |  |  | 72,499 | 79,222
Share-based compensation expense |  | 28,186 |  |  | 27,475 |  |  | 82,757 | 87,814
Interest income |  | (4,376) |  |  | (2,889) |  |  | (9,641) | (9,377)
Interest expense |  | 11,279 |  |  | 12,532 |  |  | 33,480 | 28,857
Income tax expense |  | 602 |  |  | 592 |  |  | 1,409 | 876
Net income/(loss) |  | $ 215,715 |  |  | $ (57,445) |  |  | $ 81,339 | $ (161,525)
[1] | Other segment items include cost of sales and other expenses.

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