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Condensed Consolidated Statements of Operations and Comprehensive Loss (Unaudited) - USD ($)
shares in Thousands, $ in Thousands
3 Months Ended 9 Months Ended
Sep. 30, 2025
Sep. 30, 2024
Sep. 30, 2025
Sep. 30, 2024
Revenue:        
Revenue $ 458,578 $ 196,830 $ 803,869 $ 568,839
Operating expenses:        
Cost of sales 24,531 33,557 72,517 76,867
Research and development 68,186 88,569 221,621 251,216
Selling, general and administrative 142,678 121,984 403,162 379,571
Total operating expenses: 235,395 244,110 697,300 707,654
Net operating loss 223,183 (47,280) 106,569 (138,815)
Loss on extinguishment of development liability       (1,949)
Interest income 4,376 2,889 9,641 9,377
Interest expense (11,279) (12,532) (33,480) (28,857)
Other income/(expense), net 37 70 18 (405)
Net loss before taxes 216,317 (56,853) 82,748 (160,649)
Income tax expense 602 592 1,409 876
Net income/(loss) 215,715 (57,445) 81,339 (161,525)
Other comprehensive income/(loss):        
Unrealized gain on pension benefits 137   137  
Foreign currency translation 32 222 771 402
Total other comprehensive income 169 222 908 402
Comprehensive loss, net of tax $ 215,884 $ (57,223) $ 82,247 $ (161,123)
Net loss per common share, basic $ 1.71 $ (0.46) $ 0.65 $ (1.31)
Net loss per common share, diluted $ 1.67 $ (0.46) $ 0.65 $ (1.31)
Weighted-average number of common shares used in net loss per common share, basic 126,424 124,234 125,971 123,698
Weighted-average number of common shares used in net loss per common share, diluted 130,067 124,234 129,653 123,698
Product revenue, net [Member]        
Revenue:        
Revenue $ 177,755 $ 176,571 $ 499,042 $ 518,782
Licensing and other revenue [Member]        
Revenue:        
Revenue $ 280,823 $ 20,259 $ 304,827 $ 50,057