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Segment Information - Schedule of Segment Revenue, Segment Profit or Loss and Significant Segment Expenses (Detail) - USD ($)
$ in Thousands
 3 Months Ended 9 Months Ended
Sep. 30, 2025
Jun. 30, 2025
Mar. 31, 2025
Sep. 30, 2024
Jun. 30, 2024
Mar. 31, 2024
Sep. 30, 2025
Sep. 30, 2024
Less:                
Interest income $ (4,376)     $ (2,889)     $ (9,641) $ (9,377)
Interest expense 11,279     12,532     33,480 28,857
Income tax expense 602     592     1,409 876
Net income/(loss) 215,715 $ (42,151) $ (92,225) (57,445) $ (37,657) $ (66,423) 81,339 (161,525)
Reported Segment [Member]                
Segment Reporting Information [Line Items]                
Revenue 458,578     196,830     803,869 568,839
Less:                
Internal research and development costs 19,225     20,217     63,867 61,084
Internal selling, general and administrative costs 44,938     42,814     135,133 132,942
External commercial costs 59,690     55,392     176,764 173,271
External research and development costs 36,982     56,499     122,573 150,653
External general and administrative costs 21,842     8,154     43,689 25,022
Other segment items [1] 24,495     33,489     72,499 79,222
Share-based compensation expense 28,186     27,475     82,757 87,814
Interest income (4,376)     (2,889)     (9,641) (9,377)
Interest expense 11,279     12,532     33,480 28,857
Income tax expense 602     592     1,409 876
Net income/(loss) $ 215,715     $ (57,445)     $ 81,339 $ (161,525)
[1] Other segment items include cost of sales and other expenses.